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Anti-FZD5 Antibody (R3S52)

Catalog #:   RHG54402 Specific References (23) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: ELISA, FCM, WB
Accession: Q13467
Overview

Catalog No.

RHG54402

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000

Target

Frizzled-5, FzE5, C2orf31, hFz5, FZD5, Fz-5

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q13467

Applications

ELISA, FCM, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3S52

Data Image
  • Flow Cytometry
    Flow cytometric analysis of HepG2 cells using FZD5 mouse mAb (green) and negative control (red).
  • Western blot
    Western blot analysis using FZD5 mouse mAb against A549 (1), and PC-3 (2) cell lysate.
References

Cancer-associated fibroblasts promote growth and dissemination of esophageal squamous cell carcinoma cells by secreting WNT family member 5A., PMID:39954174

Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification., PMID:38358799

Ehrlichia Wnt SLiM ligand mimic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis., PMID:37530530

Ehrlichia Wnt short linear motif ligand mimetic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis., PMID:36945589

Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling., PMID:35569814

WNT5A Interacts With FZD5 and LRP5 to Regulate Proliferation and Self-Renewal of Endometrial Mesenchymal Stem-Like Cells., PMID:35295855

The fluorescent biosensor for detecting N6 methyladenine FzD5 mRNA and MazF activity., PMID:34794576

IgD promotes pannus formation by activating Wnt5A-Fzd5-CTHRC1-NF-κB signaling pathway in FLS of CIA rats and the regulation of IgD-Fc-Ig fusion protein., PMID:34688134

FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts., PMID:33754039

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo., PMID:32818433

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling., PMID:32762848

A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties., PMID:30183492

Molecular genetics and targeted therapy of WNT-related human diseases (Review)., PMID:28731148

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors., PMID:27869803

CAPE suppresses migration and invasion of prostate cancer cells via activation of non-canonical Wnt signaling., PMID:27191743

Wnt5a Induces Collagen Production by Human Periodontal Ligament Cells Through TGFβ1-Mediated Upregulation of Periostin Expression., PMID:25655430

WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins., PMID:21070854

A nonautonomous role for retinal frizzled-5 in regulating hyaloid vitreous vasculature development., PMID:18791178

Sustained Wnt protein expression in chondral constructs from mesenchymal stem cells., PMID:15389636

Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas., PMID:12242657

Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled., PMID:11520064

Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation., PMID:11315916

Interaction of Frizzled 7 and Dishevelled in Xenopus., PMID:10906785

Datasheet

Document Download

Anti-FZD5 Antibody (R3S52).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-FZD5 Antibody (R3S52) [RHG54402]
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