Catalog No.
RHG45601
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
Killer cell lectin-like receptor subfamily D member 1, NK cell receptor, Natural killer cells antigen CD94, CD94, KP43, KLRD1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13241
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3S26
Complete CD16A Deficiency and Defective NK Cell Function in a Man Living with HIV., PMID:40411624
CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors., PMID:39958331
HLA-E: Immune Receptor Functional Mechanisms Revealed by Structural Studies., PMID:39753525
Generation, Characterization, and Preclinical Studies of a Novel NKG2A-Targeted Antibody BRY805 for Cancer Immunotherapy., PMID:39584993
Diagnosis of canine B-cell chronic lymphoid leukemia with a CD21 negative phenotype using the LT21 clone CD21 antibody in flow cytometry: a case report., PMID:39462364
CD94 deficiency or blockade unleashes the anti-tumor immunity in mice and humanized murine models., PMID:39424259
A role of gut microbiota metabolites in HLA-E and NKG2 blockage immunotherapy against tumors: new insights for clinical application., PMID:39229258
CD94+ natural killer cells potentiate pulmonary ischaemia-reperfusion injury., PMID:39190789
A high affinity monoclonal antibody against HLA-E-VL9 enhances natural killer cell anti-tumor killing., PMID:39026709
Phase 1/2 study of monalizumab plus durvalumab in patients with advanced solid tumors., PMID:38309722
Crosstalk Between NK Cell Receptors and Tumor Membrane Hsp70-Derived Peptide: A Combined Computational and Experimental Study., PMID:38298098
A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases., PMID:38251887
Evaluation of the TLR3 involvement during Schistosoma japonicum-induced pathology., PMID:38172683
Association of NK Cells with the Severity of Fibrosis in Patients with Chronic Hepatitis C., PMID:37443584
HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation., PMID:37390223
Population Pharmacokinetics of Monalizumab in Patients With Advanced Solid Tumors., PMID:36852723
Targets of Immune Escape Mechanisms in Cancer: Basis for Development and Evolution of Cancer Immune Checkpoint Inhibitors., PMID:36829496
Detailed phenotypic and functional characterization of CMV-associated adaptive NK cells in rhesus macaques., PMID:36518759
Induced CD45 Proximity Potentiates Natural Killer Cell Receptor Antagonism., PMID:36169352
Donor selection based on NK alloreactivity for patients with hematological malignancies., PMID:35965181
Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses., PMID:35881486
γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults., PMID:35874769
Single-cell RNA Sequencing Analysis Reveals New Immune Disorder Complexities in Hypersplenism., PMID:35865544
Comprehensive Analysis and Summary of the Value of Immunophenotypes of Mature NK Cell Tumors for Differential Diagnosis, Treatment, and Prognosis., PMID:35812422
Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3'-untranslated regions., PMID:35802353
Identification of a distinct NK-like hepatic T-cell population activated by NKG2C in a TCR-independent manner., PMID:35644434
NKG2A-checkpoint inhibition and its blockade critically depends on peptides presented by its ligand HLA-E., PMID:35596615
HLA-E*01:01 allele is associated with better response to anti-HCV therapy while homozygous status for HLA-E*01:03 allele increases the resistance to anti-HCV treatments in frequently transfused thalassemia patients., PMID:35570067
A Single-Domain TCR-like Antibody Selective for the Qa-1b/Qdm Peptide Complex Enhances Tumoricidal Activity of NK Cells via Blocking the NKG2A Immune Checkpoint., PMID:35418467
Role of NK-Like CD8+ T Cells during Asymptomatic Borrelia burgdorferi Infection., PMID:35416707
Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity., PMID:35347236
Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells., PMID:35281028
P10s-PADRE vaccine combined with neoadjuvant chemotherapy in ER-positive breast cancer patients induces humoral and cellular immune responses., PMID:34733416
NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division., PMID:34716584
High-Density of FcγRIIIA+ (CD16+) Tumor-Associated Neutrophils in Metastases Improves the Therapeutic Response of Cetuximab in Metastatic Colorectal Cancer Patients, Independently of the HLA-E/CD94-NKG2A Axis., PMID:34211852
Nonameric Peptide Orchestrates Signal Transduction in the Activating HLA-E/NKG2C/CD94 Immune Complex as Revealed by All-Atom Simulations., PMID:34206395
All-Atom Simulations Reveal a Key Interaction Network in the HLA-E/NKG2A/CD94 Immune Complex Fine-Tuned by the Nonameric Peptide., PMID:34196180
Innate Immune Checkpoint Inhibitors: The Next Breakthrough in Medical Oncology?, PMID:33850005
Higher-Order Structure Characterization of NKG2A/CD94 Protein Complex and Anti-NKG2A Antibody Binding Epitopes by Mass Spectrometry-Based Protein Footprinting Strategies., PMID:33415981
Natural killer cell phenotype is altered in HIV-exposed seronegative women., PMID:32870938
Cytoplasmic Expression of CD3ε Heterodimers by Flow Cytometry Rapidly Distinguishes Between Mature T-Cell and Natural Killer-Cell Neoplasms., PMID:32589191
Artificial feeder cells expressing ligands for killer cell immunoglobulin-like receptors and CD94/NKG2A for expansion of functional primary natural killer cells with tolerance to self., PMID:32451262
Long-Term Redistribution of Peripheral Lymphocyte Subpopulations after Switching from Calcineurin to mTOR Inhibitors in Kidney Transplant Recipients., PMID:32290462
Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells., PMID:31993060
Adaptive Features of Natural Killer Cells in Multiple Sclerosis., PMID:31681293
Autoantibodies to Killer Cell Immunoglobulin-Like Receptors in Patients With Systemic Lupus Erythematosus Induce Natural Killer Cell Hyporesponsiveness., PMID:31572377
Dose-Ranging and Cohort-Expansion Study of Monalizumab (IPH2201) in Patients with Advanced Gynecologic Malignancies: A Trial of the Canadian Cancer Trials Group (CCTG): IND221., PMID:31308062
Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8+ Tumor-Infiltrating T Lymphocyte Responses., PMID:31213473
Simian Immunodeficiency Virus Infection Modulates CD94+ (KLRD1+) NK Cells in Rhesus Macaques., PMID:31167916
Development and characterization of a canine-specific anti-CD94 (KLRD-1) monoclonal antibody., PMID:31084888
For research use only. Not for human or drug use.
