Anti-MAP3K1 Antibody (R3S25)

Catalog No.

RHG45301

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IHC: 1:100-1:200

Target

MAPK/ERK kinase kinase 1, Mitogen-activated protein kinase kinase kinase 1, MAP3K1, MEKK 1, MEKK, MEK kinase 1, MAPKKK1, MEKK1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q13233

Applications

IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3S25

Tissue-origin transcriptomic interactions as indicators of inflammatory aging and aging gene discovery., PMID:40527241

Anti-complement 5 antibody ameliorates antibody-mediated rejection after liver transplantation in rats., PMID:37398677

Early Triple-Negative Breast Cancers in a Singapore Cohort Exhibit High PIK3CA Mutation Rates Associated With Low PD-L1 Expression., PMID:36788078

Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791

Integrated Transcriptomic and Epigenetic Study of PCOS: Impact of Map3k1 and Map1lc3a Promoter Methylation on Autophagy., PMID:33763111

Langerhans cell histiocytosis: A neoplastic disorder driven by Ras-ERK pathway mutations., PMID:29107340

Impact of genetic variations in the MAPK signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: data from FIRE-3 and TRIBE trials., PMID:29045529

Polymorphisms associated with etanercept response in moderate-to-severe plaque psoriasis., PMID:28470127

Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein., PMID:24422672

Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis., PMID:22109528

The IL-8 production by Streptococcal pyrogenic exotoxin B., PMID:19855073

Alpha-lipoic acid inhibits TNF-alpha induced NF-kappa B activation through blocking of MEKK1-MKK4-IKK signaling cascades., PMID:18182252

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production., PMID:17143273

A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing., PMID:16760432

RACK1 mediates activation of JNK by protein kinase C [corrected]., PMID:16061178

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis., PMID:15466206

Regulation of Gene33 expression by insulin requires MEK-ERK activation., PMID:15358516

Fcgamma receptor signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction., PMID:14982949

Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells., PMID:14978732

Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer., PMID:14707447

Activation of endothelial extracellular signal-regulated kinase is essential for neutrophil transmigration: potential involvement of a soluble neutrophil factor in endothelial activation., PMID:14634124

Human intestinal epithelial crypt cell survival and death: Complex modulations of Bcl-2 homologs by Fak, PI3-K/Akt-1, MEK/Erk, and p38 signaling pathways., PMID:14603523

Distinct molecular pathways mediate progesterone-induced growth inhibition and focal adhesion., PMID:12970168

Rapamycin inhibits GM-CSF-induced neutrophil migration., PMID:12935893

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling., PMID:12876557

Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways., PMID:12796401

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway., PMID:12763138

Involvement of calcium/calmodulin-dependent protein kinase II in the induction of mPer1., PMID:12692905

1alpha,25-dihydroxyvitamin D3 stimulates activator protein 1 DNA-binding activity by a phosphatidylinositol 3-kinase/Ras/MEK/extracellular signal regulated kinase 1/2 and c-Jun N-terminal kinase 1-dependent increase in c-Fos, Fra1, and c-Jun expression in human keratinocytes., PMID:12648218

Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase., PMID:12587073

4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1., PMID:12391199

MEK inhibitor U0126 interferes with immunofluorescence analysis of apoptotic cell death., PMID:12210141

Inhibition of mitogen-activated protein kinase signaling by chloroquine., PMID:11994488

Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines., PMID:11992543

Convergence of signaling pathways on the activation of ERK in B cells., PMID:11976336

XK469, a novel antitumor agent, inhibits signaling by the MEK/MAPK signaling pathway., PMID:11914906

Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress., PMID:11879182

Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway., PMID:11859076

Macrophages inhibit Salmonella typhimurium replication through MEK/ERK kinase and phagocyte NADPH oxidase activities., PMID:11821396

[Mechanism of the activation of extracellular signal-regulated kinase (ERK) in prostate cancer cell lines with different metastatic potential]., PMID:11798872

Human intestinal epithelial cell survival: differentiation state-specific control mechanisms., PMID:11350749

Pharmacologic inhibitors of MKK1 and MKK2., PMID:11305115

A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2., PMID:11292831

Modulation of the basal activity of phosphatidylinositol-3-kinase/protein kinase B signaling pathway in human hepatocarcinoma cells., PMID:11261840

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase., PMID:11242082

Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells., PMID:11160861

AKT induces transcriptional activity of PU.1 through phosphorylation-mediated modifications within its transactivation domain., PMID:11133986

c-Jun NH2-terminal kinase activation leads to a FADD-dependent but Fas ligand-independent cell death in Jurkat T cells., PMID:11106658

X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway., PMID:11099494

ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage., PMID:11056157

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