Catalog No.
YHD58001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala1655-Asp1918
Predicted molecular weight
32.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23467
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
R-PTP-beta, Receptor-type tyrosine-protein phosphatase beta, PTPB, Vascular endothelial protein tyrosine phosphatase, VE-PTP, Protein-tyrosine phosphatase beta, PTPRB
Rare genetic variation in PTPRB is associated with central serous chorioretinopathy, varicose veins and glaucoma., PMID:40319023
Schlemm's canal-selective Tie2/TEK knockdown induces sustained ocular hypertension in adult mice., PMID:39368692
Characterisation of cells markers associated with IKZF1plus in BCP-ALL., PMID:39312877
Forsythoside A regulates pulmonary fibrosis by inhibiting endothelial-to-mesenchymal transition and lung fibroblast proliferation via the PTPRB signaling., PMID:38788399
Rare genetic variation in VE-PTP is associated with central serous chorioretinopathy, venous dysfunction and glaucoma., PMID:38766240
Transcriptome Analysis of Choroidal Endothelium Links Androgen Receptor Role to Central Serous Chorioretinopathy., PMID:38263930
Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava., PMID:38032480
Deciphering the implications of mitophagy-related signatures in clinical outcomes and microenvironment heterogeneity of clear cell renal cell carcinoma., PMID:37689589
Hsa_circ_0129047 sponges miR-665 to attenuate lung adenocarcinoma progression by upregulating protein tyrosine phosphatase receptor type B., PMID:36815253
Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-Specific Pathways., PMID:36787763
Whole-exome sequencing study identifies rare variants and genes associated with intraocular pressure and glaucoma., PMID:36450729
The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves' disease in the Chinese population., PMID:36397361
Novel rare mutation in a conserved site of PTPRB causes human hypoplastic left heart syndrome., PMID:36148623
DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis., PMID:35883028
The Tyrosine Phosphatase hPTPRβ Controls the Early Signals and Dopaminergic Cells Viability via the P2X7 Receptor., PMID:34884741
The transcription factor Sox30 is involved in Nile tilapia spermatogenesis., PMID:34801758
Nxhl Controls Angiogenesis by Targeting VE-PTP Through Interaction With Nucleolin., PMID:34733844
Novel Serum Biomarkers of Neurovascular Unit Associated with Cortical Amyloid Deposition., PMID:34602488
Preliminary study of genome-wide association identified novel susceptibility genes for thyroid-related hormones in Chinese population., PMID:34533693
Protein tyrosine phosphatase, receptor type B is a potential biomarker and facilitates cervical cancer metastasis via epithelial-mesenchymal transition., PMID:34516350
Anti-androgen therapy induces transcriptomic reprogramming in metastatic castration-resistant prostate cancer in a murine model., PMID:33892077
Screening of Graves' disease susceptibility genes by whole exome sequencing in a three-generation family., PMID:33568133
Study of triaryl-based sulfamic acid derivatives as HPTPβ inhibitors., PMID:32992253
In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4'-Dimethyl Ether., PMID:32801645
PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression., PMID:32663515
Nine Genes Mediate the Therapeutic Effects of Iodine-131 Radiotherapy in Thyroid Carcinoma Patients., PMID:32626543
Upregulated miR-665 expression independently predicts poor prognosis of lung cancer and facilitates tumor cell proliferation, migration and invasion., PMID:32269632
Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis., PMID:32123305
Post-radiotherapy vascular lesions of the breast: immunohistochemical and molecular features of 74 cases with long-term follow-up and literature review., PMID:32043616
miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells., PMID:31829261
Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma., PMID:31621585
Crucial lncRNAs associated with adipocyte differentiation from human adipose-derived stem cells based on co-expression and ceRNA network analyses., PMID:31534842
Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2., PMID:31427368
Whole-exome sequencing and RNA sequencing analyses of acinic cell carcinomas of the breast., PMID:31361912
A heterozygous, intragenic deletion of CNOT2 recapitulates the phenotype of 12q15 deletion syndrome., PMID:31145527
A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS)., PMID:31089155
PTPRB promotes metastasis of colorectal carcinoma via inducing epithelial-mesenchymal transition., PMID:31040266
Targeting VE-PTP phosphatase protects the kidney from diabetic injury., PMID:30886059
Protein Tyrosine Phosphatase, Receptor Type B (PTPRB) Inhibits Brown Adipocyte Differentiation through Regulation of VEGFR2 Phosphorylation., PMID:30845793
CNOT2 as the critical gene for phenotypes of 12q15 microdeletion syndrome., PMID:30768759
Exome sequencing in families with chronic central serous chorioretinopathy., PMID:30724488
Identification of mundoserone by zebrafish in vivo screening as a natural product with anti-angiogenic activity., PMID:30542405
miR-665 promotes hepatocellular carcinoma cell migration, invasion, and proliferation by decreasing Hippo signaling through targeting PTPRB., PMID:30237408
Synthesis and biological evaluation of (3'-amino-[1,1'-biphenyl]-4-yl) sulfamic acid derivatives as novel HPTPβ inhibitors., PMID:30165257
Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Regulates Retinal Axonal Projections by Inhibiting Eph and Abl Kinases in Mice., PMID:30082414
Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP., PMID:29358379
Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma., PMID:29254206
The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis., PMID:28870991
Phosphotyrosine phosphatase R3 receptors: Origin, evolution and structural diversification., PMID:28257417
Reassessment of the 12q15 deletion syndrome critical region., PMID:28159701
For research use only. Not for human or drug use.
