Catalog No.
RHG05507
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, IP: 1:100-1:200, WB: 1:500-1:1000
Target
Sphingosine-dependent protein kinase-1, PRKCD, Protein kinase C delta type, PKCD, nPKC-delta, Tyrosine-protein kinase PRKCD, SDK1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q05655
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3R17
Glycerophospholipid metabolism licenses IgE-mediated mast cell degranulation., PMID:40397574
Profile of juvenile systemic lupus erythematosus patients with a special reference to monogenic lupus and lupus nephritis: a cross-sectional study., PMID:39180524
Chronic Granulomatous Disease-Like Presentation of a Child with Autosomal Recessive PKCδ Deficiency., PMID:35585372
Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria., PMID:34693907
Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management., PMID:34447369
TREM (Triggering Receptor Expressed on Myeloid Cells)-1 Inhibition Attenuates Neuroinflammation via PKC (Protein Kinase C) δ/CARD9 (Caspase Recruitment Domain Family Member 9) Signaling Pathway After Intracerebral Hemorrhage in Mice., PMID:33947214
Blockade of anti-dsDNA ameliorates systemic lupus erythematosus in MRL/Faslpr mice through ameliorating inflammation via the PKCδ-NLRC4 axis., PMID:33064961
Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer., PMID:30670633
Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C δ., PMID:30257684
De novo mutations implicate novel genes in systemic lupus erythematosus., PMID:29177435
Deep Phospho- and Phosphotyrosine Proteomics Identified Active Kinases and Phosphorylation Networks in Colorectal Cancer Cell Lines Resistant to Cetuximab., PMID:28874695
TRAF3 as a powerful and multitalented regulator of lymphocyte functions., PMID:27154354
Genes associated with common variable immunodeficiency: one diagnosis to rule them all?, PMID:27250108
Phosphorylation of E-cadherin at threonine 790 by protein kinase Cδ reduces β-catenin binding and suppresses the function of E-cadherin., PMID:27203386
The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking., PMID:25690013
PKCδ/midkine pathway drives hypoxia-induced proliferation and differentiation of human lung epithelial cells., PMID:24500281
Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans., PMID:23430113
B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ., PMID:23319571
Phosphorylation of NLRC4 is critical for inflammasome activation., PMID:22885697
Differential gene expression profiles may differentiate responder and nonresponder patients with rheumatoid arthritis for methotrexate (MTX) monotherapy and MTX plus tumor necrosis factor inhibitor combined therapy., PMID:22753658
Dehydroepiandrosterone prevents the aggregation of platelets obtained from postmenopausal women with type 2 diabetes mellitus through the activation of the PKC/eNOS/NO pathway., PMID:22517552
Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium., PMID:21454537
Chronic stress sensitizes rats to pancreatitis induced by cerulein: role of TNF-α., PMID:21105189
Targeting PKC delta-mediated topoisomerase II beta overexpression subverts the differentiation block in a retinoic acid-resistant APL cell line., PMID:20200558
Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta., PMID:19809797
Differential effect of molecular size HA in mouse chondrocytes stimulated with PMA., PMID:19607883
HIV-1 Tat protein induces IL-10 production by an alternative TNF-alpha-independent pathway in monocytes: role of PKC-delta and p38 MAP kinase., PMID:18541226
Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina., PMID:16503160
Double knockout mice show BASH and PKCdelta have different epistatic relationships in B cell maturation and CD40-mediated activation., PMID:16481047
The signaling network of transforming growth factor beta1, protein kinase Cdelta, and integrin underlies the spreading and invasiveness of gastric carcinoma cells., PMID:16055706
Abnormal group I metabotropic glutamate receptor expression and signaling in the frontal cortex in Pick disease., PMID:16042316
Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells., PMID:15972820
Endothelin-1 regulates protein kinase C isoforms differently in smooth muscle cells and in cardiomyocytes., PMID:15838306
Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts., PMID:15792354
Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis., PMID:15774464
Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo., PMID:15684326
PKCdelta is involved in signal attenuation in CD3+ T cells., PMID:15585335
Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes., PMID:15494525
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment., PMID:15457440
Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling., PMID:15361883
High ambient glucose enhances sensitivity to TGF-beta1 via extracellular signal--regulated kinase and protein kinase Cdelta activities in human mesangial cells., PMID:15284289
Protein kinase C-alpha-induced hypertrophy of neonatal rat ventricular myocytes., PMID:15271671
Rac and protein kinase C-delta regulate ERKs and cytosolic phospholipase A2 in FcepsilonRI signaling to cysteinyl leukotriene synthesis in mast cells., PMID:15210825
Protein kinase Cdelta as gonadotropin-releasing hormone target isoenzyme in the alphaT3-1 gonadotrope cell line., PMID:15153754
B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta., PMID:15138267
Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes., PMID:14970215
Activation of CEA-CAM-1-mediated cell adhesion via CD98: involvement of PKCdelta., PMID:14527684
Characterization of protein kinase C-delta in mouse oocytes throughout meiotic maturation and following egg activation., PMID:12826574
Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis., PMID:12786795
A critical role for PKC zeta in endothelin-1-induced uterine contractions at the end of pregnancy., PMID:12748064