Anti-PRKCD Antibody (R3R17)

Catalog No.

RHG05507

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IHC: 1:100-1:200, IP: 1:100-1:200, WB: 1:500-1:1000

Target

Sphingosine-dependent protein kinase-1, PRKCD, Protein kinase C delta type, PKCD, nPKC-delta, Tyrosine-protein kinase PRKCD, SDK1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q05655

Applications

IHC, IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3R17

Glycerophospholipid metabolism licenses IgE-mediated mast cell degranulation., PMID:40397574

Profile of juvenile systemic lupus erythematosus patients with a special reference to monogenic lupus and lupus nephritis: a cross-sectional study., PMID:39180524

Chronic Granulomatous Disease-Like Presentation of a Child with Autosomal Recessive PKCδ Deficiency., PMID:35585372

Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria., PMID:34693907

Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management., PMID:34447369

TREM (Triggering Receptor Expressed on Myeloid Cells)-1 Inhibition Attenuates Neuroinflammation via PKC (Protein Kinase C) δ/CARD9 (Caspase Recruitment Domain Family Member 9) Signaling Pathway After Intracerebral Hemorrhage in Mice., PMID:33947214

Blockade of anti-dsDNA ameliorates systemic lupus erythematosus in MRL/Faslpr mice through ameliorating inflammation via the PKCδ-NLRC4 axis., PMID:33064961

Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer., PMID:30670633

Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C δ., PMID:30257684

De novo mutations implicate novel genes in systemic lupus erythematosus., PMID:29177435

Deep Phospho- and Phosphotyrosine Proteomics Identified Active Kinases and Phosphorylation Networks in Colorectal Cancer Cell Lines Resistant to Cetuximab., PMID:28874695

TRAF3 as a powerful and multitalented regulator of lymphocyte functions., PMID:27154354

Genes associated with common variable immunodeficiency: one diagnosis to rule them all?, PMID:27250108

Phosphorylation of E-cadherin at threonine 790 by protein kinase Cδ reduces β-catenin binding and suppresses the function of E-cadherin., PMID:27203386

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking., PMID:25690013

PKCδ/midkine pathway drives hypoxia-induced proliferation and differentiation of human lung epithelial cells., PMID:24500281

Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans., PMID:23430113

B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ., PMID:23319571

Phosphorylation of NLRC4 is critical for inflammasome activation., PMID:22885697

Differential gene expression profiles may differentiate responder and nonresponder patients with rheumatoid arthritis for methotrexate (MTX) monotherapy and MTX plus tumor necrosis factor inhibitor combined therapy., PMID:22753658

Dehydroepiandrosterone prevents the aggregation of platelets obtained from postmenopausal women with type 2 diabetes mellitus through the activation of the PKC/eNOS/NO pathway., PMID:22517552

Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium., PMID:21454537

Chronic stress sensitizes rats to pancreatitis induced by cerulein: role of TNF-α., PMID:21105189

Targeting PKC delta-mediated topoisomerase II beta overexpression subverts the differentiation block in a retinoic acid-resistant APL cell line., PMID:20200558

Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta., PMID:19809797

Differential effect of molecular size HA in mouse chondrocytes stimulated with PMA., PMID:19607883

HIV-1 Tat protein induces IL-10 production by an alternative TNF-alpha-independent pathway in monocytes: role of PKC-delta and p38 MAP kinase., PMID:18541226

Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina., PMID:16503160

Double knockout mice show BASH and PKCdelta have different epistatic relationships in B cell maturation and CD40-mediated activation., PMID:16481047

The signaling network of transforming growth factor beta1, protein kinase Cdelta, and integrin underlies the spreading and invasiveness of gastric carcinoma cells., PMID:16055706

Abnormal group I metabotropic glutamate receptor expression and signaling in the frontal cortex in Pick disease., PMID:16042316

Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells., PMID:15972820

Endothelin-1 regulates protein kinase C isoforms differently in smooth muscle cells and in cardiomyocytes., PMID:15838306

Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts., PMID:15792354

Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis., PMID:15774464

Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo., PMID:15684326

PKCdelta is involved in signal attenuation in CD3+ T cells., PMID:15585335

Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes., PMID:15494525

B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment., PMID:15457440

Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling., PMID:15361883

High ambient glucose enhances sensitivity to TGF-beta1 via extracellular signal--regulated kinase and protein kinase Cdelta activities in human mesangial cells., PMID:15284289

Protein kinase C-alpha-induced hypertrophy of neonatal rat ventricular myocytes., PMID:15271671

Rac and protein kinase C-delta regulate ERKs and cytosolic phospholipase A2 in FcepsilonRI signaling to cysteinyl leukotriene synthesis in mast cells., PMID:15210825

Protein kinase Cdelta as gonadotropin-releasing hormone target isoenzyme in the alphaT3-1 gonadotrope cell line., PMID:15153754

B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta., PMID:15138267

Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes., PMID:14970215

Activation of CEA-CAM-1-mediated cell adhesion via CD98: involvement of PKCdelta., PMID:14527684

Characterization of protein kinase C-delta in mouse oocytes throughout meiotic maturation and following egg activation., PMID:12826574

Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis., PMID:12786795

A critical role for PKC zeta in endothelin-1-induced uterine contractions at the end of pregnancy., PMID:12748064

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