Anti-MVK Antibody (R3Q84)

Catalog No.

RHF99204

Species reactivity

Human

Host species

Mouse

Isotype

IgG2b

Clonality

Monoclonal

Tested applications

IP: 1:100-1:200, WB: 1:500-1:1000

Target

MVK, MK, Mevalonate kinase

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q03426

Applications

IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3Q84

Model-informed development of a cost-saving dosing regimen for enfortumab vedotin., PMID:39998586

Chemoproteomics reveals proteome-wide covalent and non-covalent targets of withaferin A., PMID:39900821

A self-amplifying RNA RSV prefusion-F vaccine elicits potent immunity in pre-exposed and naïve non-human primates., PMID:39543172

Hypergammaglobulinemia D and Periodic Fever Syndrome (HIDS) in a 3-year-old Patient from Puerto Rico., PMID:39269768

Leishmania donovani mevalonate kinase regulates host actin for inducing phagocytosis., PMID:38123120

Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C., PMID:37870968

Long-term efficacy of canakinumab in hyperimmunoglobulin D syndrome., PMID:37578023

Safety and clinical activity of autologous RNA chimeric antigen receptor T-cell therapy in myasthenia gravis (MG-001): a prospective, multicentre, open-label, non-randomised phase 1b/2a study., PMID:37353278

A possibly new autoinflammatory disease due to compound heterozygous phosphomevalonate kinase gene mutation., PMID:36410683

Selective IgA Deficiency in Spontaneously Hypertensive Rats With Gut Dysbiosis., PMID:35950503

[Analysis of MVK gene variant in a child with high IgD syndrome caused by mevalonate kinase deficiency]., PMID:35446978

Homozygous V377I mutation causing mevalonate kinase., PMID:35387795

Uveitis, glaucoma, and cataract with mevalonate kinase deficiency., PMID:35158047

Copper-64-Labeled Antibody Fragments for Immuno-PET/Radioimmunotherapy with Low Renal Radioactivity Levels and Amplified Tumor-Kidney Ratios., PMID:34471758

C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases., PMID:34155115

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial., PMID:34102137

An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy., PMID:33796402

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies., PMID:33731724

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation., PMID:33563762

Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs., PMID:33326804

Small airway dysfunction as predictor and marker for clinical response to biological therapy in severe eosinophilic asthma: a longitudinal observational study., PMID:33087134

Immunogenicity and safety of an adjuvanted inactivated polio vaccine, IPV-Al, following vaccination in children at 2, 4, 6 and at 15-18 months., PMID:32273184

Mevalonate kinase deficiency masked by cytomegalovirus infection and obscure liver disease., PMID:31430439

Whole exome sequencing approach to childhood onset familial erythrodermic psoriasis unravels a novel mutation of CARD14 requiring unusual high doses of ustekinumab., PMID:31286971

Canakinumab for the treatment of hyperimmunoglobulin D syndrome., PMID:30652926

Tocilizumab for the Treatment of Mevalonate Kinase Deficiency., PMID:30225156

A Gallium-67/68-Labeled Antibody Fragment for Immuno-SPECT/PET Shows Low Renal Radioactivity Without Loss of Tumor Uptake., PMID:29666303

National survey of Japanese patients with mevalonate kinase deficiency reveals distinctive genetic and clinical characteristics., PMID:29451047

Mevalonate kinase deficiency associated with ataxia and retinitis pigmentosa in two brothers with MVK gene mutations., PMID:28095071

Hyper-IgD and periodic fever syndrome (HIDS) due to compound heterozygosity for G336S and V377I in a 44-year-old patient with a 27-year history of fever., PMID:27899390

Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling., PMID:27113535

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection., PMID:26124093

A restrospective survey of patients's journey before the diagnosis of mevalonate kinase deficiency., PMID:25677409

Comment to Santos et al., "hyper-IgD and periodic fever syndrome: a new MVK mutation (p.R277G) associated with a severe phenotype"., PMID:25620160

Current advances in the understanding and treatment of mevalonate kinase deficiency., PMID:25572728

Hyper-IgD and periodic fever syndrome: a new MVK mutation (p.R277G) associated with a severe phenotype., PMID:24656624

Intermittent neutropenia as an early feature of mild mevalonate kinase deficiency., PMID:24177804

Mevalonate kinase genotype in children with recurrent fevers and high serum IgD level., PMID:23239036

Recurrent abdominal pain as the presentation of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in an Asian girl: a case report and review of the literature., PMID:22921805

Establishment of a transgenic mouse model with liver-specific expression of secretory immunoglobulin D., PMID:22527518

Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS)., PMID:21607759

Elevated immunoglobulin D levels in children with PFAPA syndrome., PMID:21196927

[Utility of denaturing high performance liquid chromatography (DHPLC) for the diagnosis of mevalonate kinase deficiency in periodic disease]., PMID:19888504

Evidence for the association of luteinizing hormone receptor mRNA-binding protein with the translating ribosomes during receptor downregulation., PMID:19716387

Long-term follow-up, clinical features, and quality of life in a series of 103 patients with hyperimmunoglobulinemia D syndrome., PMID:19011501

B cell cytopenia in two brothers with hyper-IgD and periodic fever syndrome., PMID:18839211

Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome., PMID:18008182

Diagnostic value of serum immunoglobulinaemia D level in patients with a clinical suspicion of hyper IgD syndrome., PMID:17804452

[MVK gene abnormality and new approach to treatment of hyper IgD syndrome and periodic fever syndrome]., PMID:17473510

Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency., PMID:16802371

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