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Anti-XPC Antibody (R3Q44)

Catalog #:   RHF89601 Specific References (43) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: ELISA, FCM, IF, IHC, WB
Accession: Q01831
Overview

Catalog No.

RHF89601

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:50-1:200, IHC: 1:200-1:1000, WB: 1:500-1:2000

Target

Xeroderma pigmentosum group C-complementing protein, p125, XPC, DNA repair protein complementing XP-C cells, XPCC

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q01831

Applications

ELISA, FCM, IF, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3Q44

Data Image
  • Flow Cytometry
    Flow cytometric analysis of Hela cells using XPC mouse mAb (green) and negative control (red).
  • Immunofluorescence
    Immunofluorescence analysis of Hela cells using XPC mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using XPC mouse mAb with DAB staining.
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using XPC mouse mAb with DAB staining.
  • Western blot
    Western blot analysis using XPC mouse mAb against Jurkat (1) and Hela (2) cell lysate.
  • Western blot
    Western blot analysis using XPC mouse mAb against Jurkat (1) and Hela (2) cell lysate.
References

Immune checkpoint inhibitors for children with xeroderma pigmentosum and advanced cutaneous squamous cell carcinoma: A case presentation and brief review., PMID:40052589

Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency., PMID:39600699

Direct Functionalization of Polysaccharide-Based Xylan Phenyl Carbonate Nanoparticles with Tumor Cell Specific Antibodies., PMID:38236789

Regulation of XPC Binding Dynamics and Global Nucleotide Excision Repair by p63 and Vitamin D Receptor., PMID:36877866

Recurrent squamous cell carcinoma and a novel mutation in a patient with xeroderma pigmentosum: a case report., PMID:35902966

Vitamin D Receptor Promotes Global Nucleotide Excision Repair by Facilitating XPC Dissociation from Damaged DNA., PMID:33524369

Downregulation of Xeroderma Pigmentosum Complementation Group C Expression by 17-Allylamino-17-Demethoxygeldanamycin Enhances Bevacizumab-Induced Cytotoxicity in Human Lung Cancer Cells., PMID:33202406

Growth and humoral immune effects of dietary Original XPC in layer pullets challenged with Mycoplasma gallisepticum., PMID:32475439

Effects of a Saccharomyces cerevisiae fermentation product in receiving diets of newly weaned beef steers. I. Growth performance and antioxidant defense1., PMID:29912425

An improved method for the detection of nucleotide excision repair factors at local UV DNA damage sites., PMID:28185850

Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage., PMID:27642047

Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model., PMID:27467592

Clinicopathological Features of Ophthalmic Neoplasms Arising in the Setting of Xeroderma Pigmentosum., PMID:27172099

This paper is a winner in the Undergraduate category for the SFB awards: Evaluation of the tissue response to alginate encapsulated islets in an omentum pouch model., PMID:27144389

Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA., PMID:26733197

Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells., PMID:25901318

Repair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons., PMID:24218596

Malignant melanoma cells acquire resistance to DNA interstrand cross-linking chemotherapeutics by p53-triggered upregulation of DDB2/XPC-mediated DNA repair., PMID:23604128

Clinicopathological significance and prognostic value of Xeroderma pigmentosum complementary group C (XPC) expression in sporadic breast cancer patients., PMID:22038723

DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma., PMID:21390502

XPC silencing sensitizes glioma cells to arsenic trioxide via increased oxidative damage., PMID:20403967

Photoactivated DNA analogs of substrates of the nucleotide excision repair system and their interaction with proteins of NER-competent HeLa cell extract., PMID:19538122

[Expression of MMP-9 and VEGF in breast cancer: correlation with other prognostic indicators]., PMID:19142506

Direct involvement of the tumor suppressor p53 in nucleotide excision repair., PMID:18343205

DNA repair triggered by sensors of helical dynamics., PMID:17962020

Influence of XPB helicase on recruitment and redistribution of nucleotide excision repair proteins at sites of UV-induced DNA damage., PMID:17509950

Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei., PMID:16571898

p8/TTD-A as a repair-specific TFIIH subunit., PMID:16427011

DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation., PMID:16030353

Recombinant expression of maize nucleotide excision repair protein Rad23 in Escherichia coli., PMID:15866714

Use of mutant mice in photoimmunological and photocarcinogenic investigations., PMID:12231197

Sequential assembly of the nucleotide excision repair factors in vivo., PMID:11511374

Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome., PMID:11259578

Characteristics of UV-induced repair patches relative to the nuclear skeleton in human fibroblasts., PMID:10719035

Photocrosslinking locates a binding site for the large subunit of human replication protein A to the damaged strand of cisplatin-modified DNA., PMID:10454616

C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins., PMID:9858600

Assembly, subunit composition, and footprint of human DNA repair excision nuclease., PMID:9618470

Identification and characterization of XPC-binding domain of hHR23B., PMID:9372923

The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes., PMID:9364218

XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes., PMID:8692695

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway., PMID:8675009

Characterization of the properties of a human homologue of Escherichia coli RecQ from xeroderma pigmentosum group C and from HeLa cells., PMID:8790942

Detection of nucleotide excision repair incisions in human fibroblasts by immunostaining for PCNA., PMID:7493631

Datasheet

Document Download

Anti-XPC Antibody (R3Q44).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-XPC Antibody (R3Q44) [RHF89601]
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