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Anti-XIAP Antibody (R3Q06)

Catalog #:   RHF79501 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2b
Applications: ELISA, FCM
Accession: P98170
Overview

Catalog No.

RHF79501

Species reactivity

Human

Host species

Mouse

Isotype

IgG2b

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400

Target

ILP, IAP-like protein, X-linked inhibitor of apoptosis protein, IAP-3, hILP, X-linked IAP, Baculoviral IAP repeat-containing protein 4, Inhibitor of apoptosis protein 3, RING-type E3 ubiquitin transferase XIAP, E3 ubiquitin-protein ligase XIAP, API3, XIAP, hIAP-3, hIAP3, BIRC4, IAP3

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P98170

Applications

ELISA, FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3Q06

Data Image
  • Flow Cytometry
    Flow cytometric analysis of Hela cells using XIAP mouse mAb (green) and negative control (red).
References

In Silico Molecular Docking of 2-Hydroxyanthraquinone-Substituted Spiro-/Ansa Cyclotriphosphazenes: Targeting Apoptosis via Heat Shock Protein Modulation in Breast and Colon Cancer Cells., PMID:40296721

Delineating MYC-Mediated Escape Mechanisms from Conventional and T Cell-Redirecting Therapeutic Antibodies., PMID:39596160

An 8-aminoquinoline-naphthyl copper complex causes apoptotic cell death by modulating the expression of apoptotic regulatory proteins in breast cancer cells., PMID:38908670

Clinical features and lymphocyte immunophenotyping analysis in primary immunodeficiency patients with non-transplant lymphoproliferative disorders., PMID:38838929

CD62-L down-regulation after L18-MDP stimulation as a complementary flow cytometry functional assay for the diagnosis of XIAP deficiency., PMID:38770762

Repurposing the diuretic benzamil as an anti-osteosarcoma agent that acts by suppressing integrin/FAK/STAT3 signalling and compromising mitochondrial function., PMID:38569602

Maternal diet during gestation affect prostatic tissue component in SHR/Izm offspring., PMID:38032025

TP induces hepatic intolerance to FasL-mediated hepatocyte apoptosis by inhibiting XIAP., PMID:37944651

Cleaved caspase-3 is present in the majority of glial cells in the intact rat spinal cord during postnatal life., PMID:37938347

Multi-kinase compensation rescues EGFR knockout in a cell line model of head and neck squamous cell carcinoma., PMID:37844343

Alemtuzumab-based reduced-intensity conditioning for XIAP deficiency., PMID:37534620

β-Lapachone Exerts Anticancer Effects by Downregulating p53, Lys-Acetylated Proteins, TrkA, p38 MAPK, SOD1, Caspase-2, CD44 and NPM in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells., PMID:37373014

Refractory atopic dermatitis in a child with hypomorphic mutation in XIAP gene and low serum IgG., PMID:37334779

Clinical Features and Genetic Analysis of Taiwanese Primary Immunodeficiency Patients with Prolonged Diarrhea and Monogenetic Inflammatory Bowel Disease., PMID:37202577

A natural goldmine of binding proteins and soluble receptors simplified their translation to blockbuster drugs, all in one decade., PMID:36875111

Inhibitor of apoptosis proteins antagonist SM164 ameliorates experimental MPO-ANCA-associated vasculitis via enhancing fatty acid oxidation in neutrophils., PMID:36308438

When to suspect inborn errors of immunity in Epstein-Barr virus-related lymphoproliferative disorders., PMID:36209991

Small molecule profiling to define synergistic EGFR inhibitor combinations in head and neck squamous cell carcinoma., PMID:35224804

β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models., PMID:34638895

Copper-imidazo[1,2-a]pyridines differentially modulate pro- and anti-apoptotic protein and gene expression in HL-60 and K562 leukaemic cells to cause apoptotic cell death., PMID:34634376

Supplementation of oleic acid, stearic acid, palmitic acid and β-hydroxybutyrate increase H3K9me3 in endometrial epithelial cells of cattle cultured in vitro., PMID:34560342

Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management., PMID:34447369

IL13Rα2‑ and EGFR‑targeted pseudomonas exotoxin potentiates the TRAIL‑mediated death of GBM cells., PMID:34080646

Eukaryotic Translation Initiation Factor 3 Subunit B Is a Promoter in the Development and Progression of Pancreatic Cancer., PMID:33996561

Bone Marrow Mesenchymal Stromal Cell-mediated Resistance in Multiple Myeloma Against NK Cells can be Overcome by Introduction of CD38-CAR or TRAIL-variant., PMID:33898931

High ROS Production by Celecoxib and Enhanced Sensitivity for Death Ligand-Induced Apoptosis in Cutaneous SCC Cell Lines., PMID:33807213

Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant., PMID:33257690

Targeting X chromosome-linked inhibitor of apoptosis protein in mucoepidermoid carcinoma of the head and neck: A novel therapeutic strategy using nitidine chloride., PMID:32901343

Expanding clinical spectrum of female X-linked lymphoproliferative syndrome 2., PMID:32686289

Galectin-3 mediates survival and apoptosis pathways during Trypanosoma cruzi-host cell interplay., PMID:32535113

The Effect of Nanosystems on ATP-Binding Cassette Transporters: Understanding the Influence of Nanosystems on Multidrug Resistance Protein-1 and P-glycoprotein., PMID:32290047

Pemetrexed sensitizes human lung cancer cells to cytotoxic immune cells., PMID:32232903

Curcumin augments therapeutic efficacy of TRAIL-based immunotoxins in leukemia., PMID:32141025

Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma., PMID:32054850

The Use of Antibody Arrays in the Discovery of New Plasma Biomarkers for Endometriosis., PMID:32016799

Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways., PMID:31831875

The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma., PMID:31521140

Novel Carbazole-Piperazine Hybrid Small Molecule Induces Apoptosis by Targeting BCL-2 and Inhibits Tumor Progression in Lung Adenocarcinoma in Vitro and Xenograft Mice Model., PMID:31450709

ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells., PMID:31443721

Immunity to X-linked inhibitor of apoptosis protein (XIAP) in malignant melanoma and check-point blockade., PMID:31317218

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy., PMID:31266830

Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid., PMID:31248140

Overlapping dermatologic diagnoses in severe Crohn's disease with duel genetic mutations., PMID:31209857

Nimbolide induced apoptosis by activating ERK-mediated inhibition of c-IAP1 expression in human hepatocellular carcinoma cells., PMID:29962003

G-quartet oligonucleotide mediated delivery of functional X-linked inhibitor of apoptosis protein into retinal cells following intravitreal injection., PMID:29864441

A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity., PMID:29679556

Calmodulin antagonist enhances DR5-mediated apoptotic signaling in TRA-8 resistant triple negative breast cancer cells., PMID:29663486

Evidence for the role of INSL3 on sperm production in boars by passive immunisation., PMID:29575065

Identification of prefrontal cortex protein alterations in Alzheimer's disease., PMID:29541381

Analysis of Genes Associated With Monogenic Primary Immunodeficiency Identifies Rare Variants in XIAP in Patients With Crohn's Disease., PMID:29501442

Datasheet

Document Download

Anti-XIAP Antibody (R3Q06).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-XIAP Antibody (R3Q06) [RHF79501]
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