Catalog No.
RHF56801
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000
Target
GNAS1, GNAS, GSP, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Adenylate cyclase-stimulating G alpha protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P63092
Applications
ELISA, FCM, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3P28
Burosumab treatment of a child with McCune-Albright syndrome/polyostotic fibrous dysplasia: challenges and benefits., PMID:40297189
Discovery of mutations predictive of survival benefit from immunotherapy in first-line NSCLC: A retrospective machine learning study of IMpower150 liquid biopsy data., PMID:40043417
Combined Molecular Subclass and Immune Phenotype Correlate to Atezolizumab Plus Radiation Therapy Response in Invasive Bladder Cancer: BPT-ART Phase 2 Study., PMID:39755215
Lung adenocarcinomas with mucinous histology: clinical, genomic, and immune microenvironment characterization and outcomes to immunotherapy-based treatments and KRASG12C inhibitors., PMID:39637943
Molecular screening with liquid biopsy for anti-EGFR retreatment in metastatic colorectal cancer: preliminary data from the randomized phase 2 PARERE trial., PMID:38406172
Genetic mutations in HER2-positive breast cancer: possible association with response to trastuzumab therapy., PMID:37202799
Clinical value of RANKL, OPG, IL-6 and sclerostin as biomarkers for fibrous dysplasia/McCune-Albright syndrome., PMID:36958543
CC Genotype of GNAS c.393C>T (rs7121) Polymorphism Has a Protective Effect against Development of BK Viremia and BKV-Associated Nephropathy after Renal Transplant., PMID:36297195
Characterization of sporadic somatotropinomas with high GIP receptor expression., PMID:36066838
Identification of the ataxin-1 interaction network and its impact on spinocerebellar ataxia type 1., PMID:35906672
Mucinous Histology Is Associated with Resistance to Anti-EGFR Therapy in Patients with Left-Sided RAS/BRAF Wild-Type Metastatic Colorectal Cancer., PMID:35641204
RANKL inhibition halts lesion progression and promotes bone remineralization in mice with fibrous dysplasia., PMID:34952228
Identification of novel autoantibodies based on the protein chip encoded by cancer-driving genes in detection of esophageal squamous cell carcinoma., PMID:33457096
Discovery and Validation of Serum Autoantibodies Against Tumor-Associated Antigens as Biomarkers in Gastric Adenocarcinoma Based on the Focused Protein Arrays., PMID:33346593
Using protein microarray to identify and evaluate autoantibodies to tumor-associated antigens in ovarian cancer., PMID:33185955
Whole-exome sequencing in cervical adenocarcinoma in mainland Chinese patients., PMID:35117297
Trastuzumab-induced upregulation of a protein set in extracellular vesicles emitted by ErbB2-positive breast cancer cells correlates with their trastuzumab sensitivity., PMID:33023655
Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients., PMID:31653970
Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly., PMID:30975543
Hypercalcitoninaemia in pseudohypo-parathyroidism type 1A and type 1B., PMID:30703064
Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden., PMID:30496606
Intraductal Tubulopapillary Epithelial Proliferation Associated with Type 1 Autoimmune Pancreatitis., PMID:29557419
Targeted Therapies for Targeted Populations: Anti-EGFR Treatment for EGFR-Amplified Gastroesophageal Adenocarcinoma., PMID:29449271
Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes., PMID:27641811
GNAS mutations as prognostic biomarker in patients with relapsed peritoneal pseudomyxoma receiving metronomic capecitabine and bevacizumab: a clinical and translational study., PMID:27154293
[Craniofacial fibrous dysplasia]., PMID:27017329
Tocilizumab in the treatment of a polyostotic variant of fibrous dysplasia of bone., PMID:26070936
TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib)., PMID:25403028
Pseudohypoparathyroidism with Hashimoto's thyroiditis and Turner syndrome: a case report., PMID:24915162
An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer., PMID:23752180
Measurement of thyroid stimulating immunoglobulins using a novel thyroid stimulating hormone receptor-guanine nucleotide-binding protein, (GNAS) fusion bioassay., PMID:23039881
PRKAR1A mutation affecting cAMP-mediated G protein-coupled receptor signaling in a patient with acrodysostosis and hormone resistance., PMID:22723333
A distinct microvascular endothelial gene expression profile in severe IUGR placentas., PMID:22264586
Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis., PMID:19955554
Extralarge XL(alpha)s (XXL(alpha)s), a variant of stimulatory G protein alpha-subunit (Gs(alpha)), is a distinct, membrane-anchored GNAS product that can mimic Gs(alpha)., PMID:19423757
Immunohistochemical staining for CDX-2, PDX-1, NESP-55, and TTF-1 can help distinguish gastrointestinal carcinoid tumors from pancreatic endocrine and pulmonary carcinoid tumors., PMID:19065104
Regulation of spermatogenesis in McCune-Albright syndrome: lessons from a 15-year follow-up., PMID:18505910
Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration., PMID:18077133
The GNAS1 T393C polymorphism and lack of clinical prognostic value in chronic lymphocytic leukemia., PMID:18006055
Neuroendocrine secretory protein-55 (NESP-55) expression discriminates pancreatic endocrine tumors and pheochromocytomas from gastrointestinal and pulmonary carcinoids., PMID:15371954
Importance of vesicle proteins in the diagnosis and treatment of neuroendocrine tumors., PMID:15153446
Functional polymorphisms in the paternally expressed XLalphas and its cofactor ALEX decrease their mutual interaction and enhance receptor-mediated cAMP formation., PMID:12719376
A patient with acute-onset HAM/TSP after blood transfusion complicated with pseudopseudohypoparathyroidism., PMID:12413020
Expression of the extra-large G protein alpha-subunit XLalphas in neuroepithelial cells and young neurons during development of the rat nervous system., PMID:11248437
For research use only. Not for human or drug use.
