Catalog No.
RHF14601
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, FcRn, FCGRT, FCRN, Neonatal Fc receptor
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P55899
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3N48
Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor TRIM21 and Transcribe Proteasome-Associated Molecules., PMID:40141410
Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway., PMID:40124052
A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy of anti-receptor binding domain antibodies elicited by SARS-CoV-2 hybrid immunity., PMID:40020261
Population Pharmacokinetic Model of Intravenous Immunoglobulin in Patients Treated for Various Immune System Disorders., PMID:39366801
Rhesus Macaques: VNTR Polymorphism of the FCGRT Gene., PMID:39134810
Identifying the immunoglobulin G transporter in equine tissues: A look at the neonatal Fc receptor., PMID:38879095
Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy., PMID:38205888
Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia., PMID:38145833
Allele mining in gene encoding fc fragment of IgG receptor, transporter, alpha (FCGRT) and association of nucleotide variants with passive transfer of immunity in neonatal buffalo calves., PMID:36757548
Decreased Infliximab Concentrations in Patients With Inflammatory Bowel Disease Who Carry a Variable Number Tandem Repeat Polymorphism in the Neonatal Fc Receptor or Variant HLADQA1*05G>A Genotype., PMID:36112504
Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia., PMID:35841099
Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids., PMID:35579465
Detection of nucleotide variants in FCGRT (Fc fragment of IgG, receptor, transporter, alpha) gene and their influence on colostral IgG concentration in Indian water buffalo (Bubalus bubalis)., PMID:35152368
Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans., PMID:34514376
Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21)., PMID:34040082
Animal models for SARS-Cov2/Covid19 research-A commentary., PMID:33812856
The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors., PMID:33717213
Genetic biomarkers for intravenous immunoglobulin response in chronic inflammatory demyelinating polyradiculoneuropathy., PMID:33460483
Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice., PMID:33025844
Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium., PMID:31209240
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex., PMID:29306331
Regulation of the Human Fc-Neonatal Receptor alpha-Chain Gene FCGRT by MicroRNA-3181., PMID:29302759
Brain antibodies in the cortex and blood of people with schizophrenia and controls., PMID:28786974
Functional polymorphisms in rhesus macaque FCGRT and β2-m., PMID:28785825
Correlation of FCGRT genomic structure with serum immunoglobulin, albumin and farletuzumab pharmacokinetics in patients with first relapsed ovarian cancer., PMID:28450240
Bevacizumab Pharmacokinetics Influence Overall and Progression-Free Survival in Metastatic Colorectal Cancer Patients., PMID:27312193
Neonatal Fc Receptor Regulation of Lung Immunoglobulin and CD103+ Dendritic Cells Confers Transient Susceptibility to Tuberculosis., PMID:27481246
Claudin-4 undergoes age-dependent change in cellular localization on pig jejunal villous epithelial cells, independent of bacterial colonization., PMID:25948883
Analysis of Fcgrt gene polymorphism in indigenous Chinese sheep and its association with colostrum IgG concentration., PMID:25867392
Polymorphisms of neonatal Fc receptor in cynomolgus and rhesus macaques., PMID:24806819
NFκB induces overexpression of bovine FcRn: a novel mechanism that further contributes to the enhanced immune response in genetically modified animals carrying extra copies of FcRn., PMID:24492342
Humanized FcRn mouse models for evaluating pharmacokinetics of human IgG antibodies., PMID:23867339
Influence of FCGRT gene polymorphisms on pharmacokinetics of therapeutic antibodies., PMID:23751752
Efficiency of immunoglobulin G replacement therapy in common variable immunodeficiency: correlations with clinical phenotype and polymorphism of the neonatal Fc receptor., PMID:23286945
Colostrogenesis: candidate genes for IgG1 transcytosis mechanisms in primary bovine mammary epithelial cells., PMID:23279563
Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis., PMID:20930418
Neonatal Fc receptor: from immunity to therapeutics., PMID:20886282
Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum., PMID:19937499
Plasma cells and Fc receptors in human adipose tissue--lipogenic and anti-inflammatory effects of immunoglobulins on adipocytes., PMID:16527253
Transport of IgG across the blood-luminal barrier of the male reproductive tract of the rat and the effect of estradiol administration on reabsorption of fluid and IgG by the epididymal ducts., PMID:15888731
Beta-2-microglobulin haplotypes in U.S. beef cattle and association with failure of passive transfer in newborn calves., PMID:15014972
Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves., PMID:12514749
For research use only. Not for human or drug use.
