Catalog No.
RHF14201
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000
Target
SLC25A8, Solute carrier family 25 member 8, UCPH, UCP 2, UCP2, Mitochondrial uncoupling protein 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P55851
Applications
ELISA, FCM, IF
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3N46
Metformin Ameliorates Ulcerative Colitis Through Inhibiting NLRP3 Inflammasome Activation., PMID:39931167
Targeting FABP4/UCP2 axis to overcome cetuximab resistance in obesity-driven CRC with drug-tolerant persister cells., PMID:39823981
Novel protocol for the transcriptomic analysis of endothelial extracellular vesicles in atherosclerosis., PMID:39271430
Mitochondria of lung venular capillaries mediate lung-liver cross talk in pneumonia., PMID:37431588
UCP-2 inhibitor enhanced the efficacy of trastuzumab against HER2 positive breast cancer cells., PMID:34146128
Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury., PMID:33997750
p53-R273H Sustains ROS, Pro-Inflammatory Cytokine Release and mTOR Activation While Reducing Autophagy, Mitophagy and UCP2 Expression, Effects Prevented by wtp53., PMID:33668399
Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome., PMID:32558367
1,25(OH)2 D3 alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation., PMID:32237257
Important Trends in UCP3 Investigation., PMID:31133866
[Soluble Uric Acid Activates NLRP3 Inflammasome in Myocardial Cells Through Down-regulating UCP2]., PMID:30378301
Leishmania donovani inhibits inflammasome-dependent macrophage activation by exploiting the negative regulatory proteins A20 and UCP2., PMID:28765172
Glia Maturation Factor and Mitochondrial Uncoupling Proteins 2 and 4 Expression in the Temporal Cortex of Alzheimer's Disease Brain., PMID:28572767
UCP1, the mitochondrial uncoupling protein of brown adipocyte: A personal contribution and a historical perspective., PMID:27916641
The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue., PMID:26518386
Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling., PMID:26431905
Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage., PMID:25077985
Mitochondrial uncoupling protein 2 protects splenocytes from oxidative stress-induced apoptosis during pathogen activation., PMID:24291389
Alteration of UCP2 and ZO-1 expression in trabecular meshwork of neovascular glaucoma patients., PMID:23835672
CRF type 2 receptors mediate the metabolic effects of ghrelin in C2C12 cells., PMID:23804489
Mapping the nucleotide binding site of uncoupling protein 1 using atomic force microscopy., PMID:23414455
UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells., PMID:23124112
WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis., PMID:21998399
Inbuilt mechanisms for overcoming functional problems inherent in hepatic microlobular structure., PMID:21547084
[Relationship between the expression of uncoupling protein 2 and the damage by oxygen free radicals in acute liver failure rats]., PMID:21272461
Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells., PMID:20976134
Identification and characterization of uncoupling protein in heart and muscle mitochondria of canary birds., PMID:20686918
Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity., PMID:20600837
Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2., PMID:19772611
Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development., PMID:19646951
Detection of uncoupling protein-2 (UCP2) as a mitochondrial modulator of apoptosis., PMID:19609759
Identification and distribution of uncoupling protein isoforms in the normal and diabetic rat kidney., PMID:19227473
Mitochondrial UCP4 attenuates MPP+ - and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression., PMID:19150400
Lack of UCP2 reduces Fas-mediated liver injury in ob/ob mice and reveals importance of cell-specific UCP2 expression., PMID:16941708
Associations of the UCP2 gene locus with asymptomatic carotid atherosclerosis in middle-aged women., PMID:15604415
Uncoupling protein 2, but not uncoupling protein 1, is expressed in the female mouse reproductive tract., PMID:12941933
Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death., PMID:12783416
[To burn or to store]., PMID:12733325
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease., PMID:12540784
Alteration of plant mitochondrial proton conductance by free fatty acids. Uncoupling protein involvement., PMID:12196511
Analysis of the gene expression profiles of immature versus mature bone marrow-derived dendritic cells using DNA arrays., PMID:11779134
The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects., PMID:11126411
Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation., PMID:11098051
Existence of uncoupling protein-2 antigen in isolated mitochondria from various tissues., PMID:10428476
Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes., PMID:10220511
Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression., PMID:10098482
Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver., PMID:10051468
Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism., PMID:9790953
Kupffer cells are a dominant site of uncoupling protein 2 expression in rat liver., PMID:9207235
For research use only. Not for human or drug use.
