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Anti-CD97/ADGRE5 Antibody (R3L83)

Catalog #:   RHE61902 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2a
Applications: ELISA, FCM, IHC
Accession: P48960
Overview

Catalog No.

RHE61902

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000

Target

ADGRE5, Adhesion G protein-coupled receptor E5, Leukocyte antigen CD97, CD97

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P48960

Applications

ELISA, FCM, IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3L83

Data Image
  • Flow Cytometry
    Flow cytometric analysis of HL-60 cells using CD97 mouse mAb (green) and negative control (red).
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CD97 mouse mAb with DAB staining.
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using CD97 mouse mAb with DAB staining.
References

CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells., PMID:39637858

Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1., PMID:38758649

sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides., PMID:38053024

Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function., PMID:38049580

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability., PMID:37938973

Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer., PMID:37272843

Targeting pediatric leukemia-propagating cells with anti-CD200 antibody therapy., PMID:34470052

Author Correction: G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody., PMID:32184438

G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody., PMID:31969668

Ibrutinib and idelalisib block immunophenotypic changes associated with the adhesion and activation of CLL cells in the tumor microenvironment., PMID:29164976

Detection of minimal residual disease in childhood B-acute lymphoblastic leukemia by 4-color flowcytometry., PMID:28324281

Membrane proteome analysis of glioblastoma cell invasion., PMID:25853691

Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism., PMID:25411767

Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts., PMID:22590509

F4/80 and the related adhesion-GPCRs., PMID:21952799

[Human CD96 gene cloning, expression and identification]., PMID:21764703

The cell surface proteome of human mesenchymal stromal cells., PMID:21637820

CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism., PMID:21169517

Oncoproteomic analysis reveals co-upregulation of RELA and STAT5 in carboplatin resistant ovarian carcinoma., PMID:20585448

Role of CD97 isoforms in gastric carcinoma., PMID:20428763

Decay-accelerating factor 1 (Daf1) deficiency exacerbates xenobiotic-induced autoimmunity., PMID:20408894

Deletion of either CD55 or CD97 ameliorates arthritis in mouse models., PMID:20131275

CD97 in leukocyte trafficking., PMID:21618832

Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2., PMID:19717518

Differential expression of CD97 on human lymphocyte subsets and limited effect of CD97 antibodies on allogeneic T-cell stimulation., PMID:19428565

Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration., PMID:18941248

Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem and progenitor cell mobilization., PMID:18326527

CD97 neutralisation increases resistance to collagen-induced arthritis in mice., PMID:17007638

Costimulation via CD55 on human CD4+ T cells mediated by CD97., PMID:16818763

Decay-accelerating factor (CD55): a versatile acting molecule in human malignancies., PMID:16784816

Rapid leukocyte activation following intraarticular bleeding., PMID:16514634

Diversity of CD97 in smooth muscle cells., PMID:16408199

Dedicated pinhole SPECT of intestinal neutrophil recruitment in a mouse model of dextran sulfate sodium-induced colitis., PMID:15750169

Intact-protein-based high-resolution three-dimensional quantitative analysis system for proteome profiling of biological fluids., PMID:15703445

Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue., PMID:15693006

Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells., PMID:15498814

N-glycosylation of CD97 within the EGF domains is crucial for epitope accessibility in normal and malignant cells as well as CD55 ligand binding., PMID:15386373

The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense., PMID:14707087

The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans., PMID:12829604

Enhanced expression of the complement regulatory protein CD55 predicts a poor prognosis in colorectal cancer patients., PMID:12811528

The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells., PMID:11994511

CD97-decay-accelerating factor interaction is not involved in leukocyte adhesion to endothelial cells., PMID:11884941

Tissue distribution of the human CD97 EGF-TM7 receptor., PMID:11380941

Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans., PMID:11157498

Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97., PMID:10903844

Molecular cloning and characterization of mouse CD97., PMID:10744645

Decay accelerating factor (CD55): a target for cancer vaccines?, PMID:10344729

Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue., PMID:10211878

Activation of peripheral blood T cells by interaction and migration through endothelium: role of lymphocyte function antigen-1/intercellular adhesion molecule-1 and interleukin-15., PMID:9920837

Phenotypic characterization of human skin mast cells by combined staining with toluidine blue and CD antibodies., PMID:9764855

Datasheet
$ 220
Product specifications
50 μg 220 100 μg 350

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For research use only. Not for human or drug use.

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Anti-CD97/ADGRE5 Antibody (R3L83) [RHE61902]
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