Catalog No.
RHE47403
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:100-1:500, IHC: 1:200-1:1000
Target
HTR3, 5-HT-3, HTR3A, 5-hydroxytryptamine receptor 3A, 5-HT3A, 5-HT3-A, Serotonin-gated ion channel receptor, 5-hydroxytryptamine receptor 3, 5-HT3R, 5HT3R, Serotonin receptor 3A
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P46098
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3L50
[Current Status and Issue of Emesis and Vomiting Caused by Trastuzumab Deruxtecan]., PMID:39957220
NEPA (netupitant/palonosetron) for the antiemetic prophylaxis of nausea and vomiting induced by chemotherapy (CINV) with Folfirinox and Folfoxiri even during the COVID-19 pandemic: a real-life study., PMID:34486707
Evaluating the incidence of chemotherapy-induced nausea and vomiting in patients with B-cell lymphoma receiving dose-adjusted EPOCH and rituximab., PMID:33435826
Stereological investigation of 5-HT3 receptors in the substantia nigra and dorsal raphe nucleus in the rat., PMID:33160048
Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus., PMID:32612073
Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site., PMID:31990273
A Novel Magnetic Contrast Agent for Gastrointestinal Mucosa-Targeted Imaging Through Oral Administration., PMID:31072425
Conformational transitions of the serotonin 5-HT3 receptor., PMID:30401839
[Evaluation of Chemotherapy-Induced Nausea and Vomiting in Patients with Hematological Malignancies Using MASCC Antiemesis Tool(MAT)]., PMID:29362306
Hwangryunhaedok-tang induces the depolarization of pacemaker potentials through 5-HT3 and 5-HT4 receptors in cultured murine small intestine interstitial cells of Cajal., PMID:28839431
Expression, Biochemistry, and Stabilization with Camel Antibodies of Membrane Proteins: Case Study of the Mouse 5-HT3 Receptor., PMID:28755368
Granisetron and carvedilol can protect experimental rats againstadjuvant-induced arthritis., PMID:28211304
Anti-Hu antibodies activate enteric and sensory neurons., PMID:27905561
In silico investigation into the interactions between murine 5-HT3 receptor and the principle active compounds of ginger (Zingiber officinale)., PMID:27816008
The Role of 5-Hydroxytryptamine in the Pathophysiology of Migraine and its Relevance to the Design of Novel Treatments., PMID:27465216
A retrospective study of R-CHOP/CHOP therapy-induced nausea and vomiting in non-Hodgkin's lymphoma patients: a comparison of intravenous and oral 5-HT3 receptor antagonists., PMID:27312042
Sequential addition of aprepitant in patients receiving carboplatin-based chemotherapy., PMID:27235141
The Structure of the Mouse Serotonin 5-HT3 Receptor in Lipid Vesicles., PMID:26724993
In vitro screening of major neurotransmitter systems possibly involved in the mechanism of action of antibodies to S100 protein in released-active form., PMID:26604768
Expression of 5-HT3 receptors and TTX resistant sodium channels (Na(V)1.8) on muscle nerve fibers in pain-free humans and patients with chronic myofascial temporomandibular disorders., PMID:25261281
Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice., PMID:22330338
Effects of serotonin on acid secretion in isolated rat stomach: the role of 5-HT3 receptors., PMID:20359130
Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma., PMID:20347047
Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon., PMID:20233224
Roles of serotonin 5-HT3 receptor in the formation of dendrites and axons in the rat cerebral cortex: an in vitro study., PMID:19766152
Pharmacological manipulation of immune-induced food aversion in rats., PMID:19077442
Excitability of small-diameter trigeminal ganglion neurons by 5-HT is mediated by enhancement of the tetrodotoxin-resistant sodium current due to the activation of 5-HT(4) receptors and/or by the inhibition of the transient potassium current., PMID:18926885
Determination of the architecture of ionotropic receptors using AFM imaging., PMID:18026748
Development of an intestinal cell culture model to obtain smooth muscle cells and myenteric neurones., PMID:17979953
Immunolabelling of the 5-HT 3B receptor subunit in the central and peripheral nervous systems in rodents., PMID:17650111
Influence of immunomodulatory drugs on the cytotoxicity induced by monoclonal antibody 17-1A and interleukin-2., PMID:17562330
Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E., PMID:17392525
Identification of 5-HT3A and 5-HT3B receptor subunits in human hippocampus., PMID:17327132
Automated analysis of the architecture of receptors, imaged by atomic force microscopy., PMID:17296302
Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor., PMID:17060161
Chronic fluoxetine treatment increases the expression of PSA-NCAM in the medial prefrontal cortex., PMID:16900104
Expression of serotonergic receptors in psoriatic skin., PMID:16794822
Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies., PMID:16571125
CYP1A1 is a major enzyme responsible for the metabolism of granisetron in human liver microsomes., PMID:16248838
Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors., PMID:16116092
Neurochemical characterization of nervous elements innervating the body wall of earthworms (Lumbricus, Eisenia): immunohistochemical and pharmacological studies., PMID:15995870
Transmitter content, origins and connections of axons in the spinal cord that possess the serotonin (5-hydroxytryptamine) 3 receptor., PMID:15975728
Receptors and transporter for serotonin in Merkel cell-nerve endings in the rat sinus hair follicle. An immunohistochemical study., PMID:15827375
Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding., PMID:15781467
Treatment of systemic sclerosis with the 5-HT3 receptor antagonist tropisetron., PMID:15515417
Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects., PMID:14755134
A paracrine signaling role for serotonin in rat taste buds: expression and localization of serotonin receptor subtypes., PMID:14715493
An in vitro study of the sub-cellular distribution of nicotinic receptors., PMID:14519554
[Pain modification by the 5-HT3 receptor antagonist tropisetron in secondary fibromyalgias]., PMID:14518353
A cytoplasmic region determines single-channel conductance in 5-HT3 receptors., PMID:12867984
For research use only. Not for human or drug use.
