Catalog No.
RHE37201
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
LIFR, LIF-R, CD118, LIF receptor, Leukemia inhibitory factor receptor
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P42702
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3K90
Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis., PMID:39636853
BMPRII+ neural precursor cells isolated and characterized from organotypic neurospheres: an in vitro model of human fetal spinal cord development., PMID:37488910
The Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights., PMID:35680099
A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis., PMID:34921145
An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy., PMID:33846527
Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans., PMID:31461490
STAT3 activation confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive breast cancer., PMID:30076657
MicroRNA-125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the Hippo signaling pathway., PMID:25962054
Bilateral giant retinal tears in a pediatric patient with leukemia inhibitory factor receptor deficiency (Stuve-Wiedemann syndrome)., PMID:25876185
Oncostatin-M differentially regulates mesenchymal and proneural signature genes in gliomas via STAT3 signaling., PMID:25748242
Feasibility of proposed single-nucleotide polymorphisms as predictive markers for targeted regimens in metastatic colorectal cancer., PMID:23579219
Effects of leukemia inhibitory factor on proliferation and odontoblastic differentiation of human dental pulp cells., PMID:21787496
Interleukins 1α and 1β as regulators of steroidogenesis in human NCI-H295R adrenocortical cells., PMID:21600230
Cardiotrophin-1 stimulates intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human aortic endothelial cells., PMID:18055523
Generation of mutant leukaemia inhibitory factor (LIF)-IgG heavy chain fusion proteins as bivalent antagonists of LIF., PMID:17408687
Isolation and characterization of human CXCR4-positive pancreatic cells., PMID:17328838
Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury., PMID:16563523
Expression of human soluble gp190 in yeast Pichia pastoris., PMID:15651668
Leptin-induced increase in leukemia inhibitory factor and its receptor by human endometrium is partially mediated by interleukin 1 receptor signaling., PMID:15142989
Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor., PMID:12707269
Mutations in the immunoglobulin-like domain of gp190, the leukemia inhibitory factor (LIF) receptor, increase or decrease its affinity for LIF., PMID:12601009
IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae., PMID:12218157
Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation., PMID:11834739
The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex., PMID:11812136
Identification of agonistic and antagonistic antibodies against gp190, the leukemia inhibitory factor receptor, reveals distinct roles for its two cytokine-binding domains., PMID:11606572
Signaling pathway of ciliary neurotrophic factor in neuroblastoma cell lines., PMID:11464862
Expression and production of interleukin 10 in human myeloma cell lines., PMID:11122145
Oncostatin M is produced during pregnancy by decidual cells and stimulates the release of HCG., PMID:10908286
Expression of leukemia inhibitory factor (LIF) and LIF receptor (LIF-R) in the human adrenal cortex: implications for steroidogenesis., PMID:10854707
Identification of a gp130 cytokine receptor critical site involved in oncostatin M response., PMID:10681548
Soluble glycoprotein 130 (gp130) attenuates OSM- and LIF-induced cartilage proteoglycan catabolism., PMID:10671300
Presence of leukaemia inhibitory factor (LIF) and LIF-receptor chain (gp190) in osteoclast-like cells cultured from human giant cell tumour of bone. Ultrastructural distribution., PMID:10328867
Binding of leukemia inhibitory factor (LIF) to mutants of its low affinity receptor, gp190, reveals a LIF binding site outside and interactions between the two cytokine binding domains., PMID:10318874
Localization of leukemia inhibitory factor and its receptor in human placenta throughout pregnancy., PMID:9916002
Phase I study of a humanized anti-CD11/CD18 monoclonal antibody in multiple sclerosis., PMID:9757158
Functional map of a placenta-specific enhancer of the human leukemia inhibitory factor receptor gene., PMID:9748286
The mannose 6-phosphate/insulin-like growth factor II receptor is a nanomolar affinity receptor for glycosylated human leukemia inhibitory factor., PMID:9694835
Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma., PMID:9553147
Expression of leukemia inhibitory factor and its receptor in breast cancer: a potential autocrine and paracrine growth regulatory mechanism., PMID:9596488
Epitope-function relationships of human leukemia inhibitory factor receptors using a novel set of anti-gp190 mAB., PMID:9466305
The unusual species cross-reactivity of the leukemia inhibitory factor receptor alpha-chain is determined primarily by the immunoglobulin-like domain., PMID:9295349
Production and characterization of monoclonal antibodies against the leukemia inhibitory factor low affinity receptor, gp190., PMID:9294600
Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component., PMID:9030543
Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop., PMID:8916964
A ciliary neurotrophic factor-sensitive human myeloma cell line., PMID:8765494
Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein., PMID:8662918
Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways., PMID:8621626
Designer cytokines: targeting actions to cells of choice., PMID:7481821
AIDS-associated Kaposi's sarcoma (KS) cells express oncostatin M (OM)-specific receptor but not leukemia inhibitory factor/OM receptor or interleukin-6 receptor. Complete block of OM-induced KS cell growth and OM binding by anti-gp130 antibodies., PMID:7657807
Screening for cytokine mRNA in human villous and extravillous trophoblasts using the reverse-transcriptase polymerase chain reaction (RT-PCR)., PMID:8589267
For research use only. Not for human or drug use.
