Catalog No.
RHE35402
Species reactivity
Human, Mouse, Rat, Rabbit
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, IHC: 1:200-1:1000
Target
RAFT1, Rapamycin target protein 1, Mechanistic target of rapamycin, FRAP, FKBP12-rapamycin complex-associated protein, mTOR, FRAP1, FK506-binding protein 12-rapamycin complex-associated protein 1, Rapamycin and FKBP12 target 1, FRAP2, RAPT1, Serine/threonine-protein kinase mTOR, Mammalian target of rapamycin, MTOR
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P42345
Applications
ELISA, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3K77
ORM1 Mediates Ln-IgG-Induced Podocyte Damage and Autophagy via the AMPK/mTOR Signaling., PMID:40526157
Conformation-specific synthetic intrabodies modulate mTOR signaling with subcellular spatial resolution., PMID:40489625
MBD2 promotes B cell differentiation and BCR signaling in systemic lupus erythematosus by regulating the LEF-1-PTEN-PI3K axis., PMID:40467564
Development and application of a targeted phosphoproteomics method for analysing the mTOR pathway dynamics in zebrafish PAC2 cell line., PMID:40466985
Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future., PMID:40463417
Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes., PMID:40447640
Comprehensive advances in HER2-positive and HER2-negative breast cancer: unveiling molecular mechanisms and exploring cutting-edge targeted therapies for enhanced patient outcomes., PMID:40439885
Hedgehog inhibitors exert anti-proliferation effects and synergistically interact with trastuzumab in HER2-positive gastric cancer models., PMID:40426308
Patient preferences for treatments in hormone receptor-positive/HER2-negative metastatic breast cancer in Italy: a discrete choice experiment study., PMID:40405072
Autophagy inhibition amplifies anti-tumor immunity effect of dinutuximab beta on neuroblastoma via the VEGFR/AKT/mTOR and ROS/NF-κB pathways., PMID:40378433
[Results of kidney transplantation in patients with end-stage renal disease caused by glomerulonephritis]., PMID:40377558
TSAb inhibits osteogenic differentiation of MC3T3-E1 cells and exacerbates bone loss in Graves' disease mice., PMID:40354515
Extensive genotype-phenotype heterogeneity in renal cell carcinoma - a proof-of-concept study., PMID:40352587
Cystatin antibodies interfere with ovary development in Haemaphysalis doenitzi (Acari: Ixodidae)., PMID:40333887
Relationship between autoimmunity and COPD: an investigation based on proteomic profiling and antinuclear antibody screening., PMID:40329569
LncRNAs and IgA nephropathy: underlying molecular pathways and clinical applications., PMID:40328979
BAFF modulates T follicular helper cell differentiation through the BAFFR-PI3K/AKT-mTOR signaling pathway in bullous pemphigoid., PMID:40328590
Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis., PMID:40327404
Enhanced cytotoxicity of T-DM1 in HER2-low carcinomas via autophagy inhibition., PMID:40315224
[Mechanism of 2,6-DMBQ attenuates airway inflammatory responses in asthmatic mice via the mTOR signaling pathway]., PMID:40241367
Multiplexed imaging mass cytometry elicits p-S6 as a therapeutic and prognostic factor in diffuse large B-cell lymphoma., PMID:40238894
Valproic acid promotes transcriptional activation of Drd2 by mediating histone acetylation to inhibit the mTOR-Pttg1 signaling axis and exerts anti-PitNETs activity., PMID:40220407
Synergistic activity of tafasitamab and metronomic chemotherapy on diffuse large B-cell lymphoma through inhibition of the AKT/mTOR signaling pathway., PMID:40175588
Integrative analysis of a novel signature incorporating metabolism and stemness-related genes for risk stratification and assessing clinical outcomes and therapeutic responses in lung adenocarcinoma., PMID:40170009
CRISPR screens with trastuzumab emtansine in HER2-positive breast cancer cell lines reveal new insights into drug resistance., PMID:40165206
Novel Estrogen Receptor - Targeted Therapies in Hormone-Receptor Positive Breast Cancer., PMID:40163189
The role of the mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials., PMID:40158191
Activation of the Mammalian Target of Rapamycin Pathway in Endothelial Cells in Antiphospholipid Antibody-Positive Patients with Leg Ulcers., PMID:40141392
Lupenone preserves T cell activity by recovery of CD40L expression and protection from cytotoxicity due to methamphetamine exposure., PMID:40111983
Targeting autophagy in autoimmune glomerular diseases., PMID:40106213
Safety of Everolimus in Lung Transplant Recipients Undergoing Surveillance Bronchoscopy with Transbronchial Forceps Biopsy and Cryobiopsy: A Retrospective Cohort Study., PMID:40094256
ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease development., PMID:40090133
BRD7 Inhibited Immune Escape in Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression., PMID:40083706
Antibody-Based and Other Novel Agents in Adult B-Cell Acute Lymphoblastic Leukemia., PMID:40075627
[Early conversion to belatacept post-transplantation: state of the art and expert opinion]., PMID:40066607
Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb., PMID:40055364
Clinical Outcomes and Treatment Strategies of Adult Transplant-Associated Thrombotic Microangiopathy: External Validation of Harmonizing Definitions and High-Risk Criteria., PMID:40047384
Stabilisation of extracellular matrix is crucial to rapamycin-mediated life span increase in Marfan mgR/mgR mice., PMID:40021021
A novel and promising therapeutic approach for treating pancreatic cancer: Nectin‑4‑targeted antibody‑drug conjugates alone or combined with autophagy inhibitors., PMID:40017149
Triple-Negative Breast Cancer Systemic Treatment: Disruptive Early-Stage Developments for Overcoming Stagnation in the Advanced Pipeline., PMID:40002228
Updates in Head and Neck Oncology - Current Knowledge and Future Horizons., PMID:39974445
NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model., PMID:39932765
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway., PMID:39923560
Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2-Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation., PMID:39917999
Signaling Activation and Modulation in Extrafollicular B Cell Responses., PMID:39917832
Molecular Mechanisms and Therapeutic Prospects of Immunotherapy and Targeted Therapy in Primary Central Nervous System Lymphoma., PMID:39912261
ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI., PMID:39903532
Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma., PMID:39875173
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice., PMID:39831928
Antiphospholipid antibodies positivity as a potential risk factor for restenosis following arteriovenous fistula stenting in hemodialysis patients: a pilot study., PMID:39830377
For research use only. Not for human or drug use.
