Catalog No.
RHE31502
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000
Target
Nuclear receptor subfamily 2 group A member 1, HNF-4-alpha, HNF4A, Hepatocyte nuclear factor 4-alpha, NR2A1, TCF14, Transcription factor 14, Transcription factor HNF-4, TCF-14, HNF4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P41235
Applications
ELISA, FCM, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3K59
Molecular and clinical profiles of pediatric monogenic diabetes subtypes: comprehensive genetic analysis of 138 patients., PMID:39504571
Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reveals Insights Into Disease Heterogeneity., PMID:39364395
Development of a clinical calculator to aid the identification of MODY in pediatric patients at the time of diabetes diagnosis., PMID:38719926
Clinical and Laboratory Characteristics of MODY Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship., PMID:38665000
Hepatocyte nuclear factor 4 located in different developmental stages of Schistosoma japonicum and involved in important metabolic pathways., PMID:38621646
Screening of Mutations in Maturity-onset Diabetes of the Young-related Genes and RFX6 in Children with Autoantibody-negative Type 1 Diabetes Mellitus., PMID:38054414
High Frequency of Recessive WFS1 Mutations Among Indian Children With Islet Antibody-negative Type 1 Diabetes., PMID:37931151
Comprehensive proteomics and platform validation of urinary biomarkers for bladder cancer diagnosis and staging., PMID:37016361
Prevalence of maturity-onset diabetes of the young in phenotypic type 2 diabetes in young adults: a nationwide, multi-center, cross-sectional survey in China., PMID:36723869
OMIP-088: Twenty-target imaging mass cytometry panel for major cell populations in mouse formalin fixed paraffin embedded liver., PMID:36602064
Identification of monogenic variants in more than ten per cent of children without type 1 diabetes-related autoantibodies at diagnosis in the Finnish Pediatric Diabetes Register., PMID:36418577
Study of the frequency and clinical features of maturity-onset diabetes in the young in the pediatric and adolescent diabetes population in Iran., PMID:36100423
The coexistence of autoimmune diabetes and maturity-onset diabetes of the young (MODY): a case series., PMID:35894830
Identification of Variants Responsible for Monogenic Forms of Diabetes in Brazil., PMID:35592779
Comparison of Different Hepatocyte Nuclear Factor 4α Clones for Invasive Mucinous Adenocarcinoma of the Lung., PMID:35510773
Comprehensive genetic screening reveals wide spectrum of genetic variants in monogenic forms of diabetes among Pakistani population., PMID:34888019
Functional screen of inflammatory bowel disease genes reveals key epithelial functions., PMID:34758847
Identification of Novel GCK and HNF4α Gene Variants in Japanese Pediatric Patients with Onset of Diabetes before 17 Years of Age., PMID:34746319
Immunohistochemical detection of hepatocyte nuclear factor-4α in vertebrates., PMID:34196449
Clinical and laboratory clues of maturity-onset diabetes of the young and determination of association with molecular diagnosis., PMID:32710514
Update on clinical screening of maturity-onset diabetes of the young (MODY)., PMID:32528556
Systematic Genetic Study of Youth With Diabetes in a Single Country Reveals the Prevalence of Diabetes Subtypes, Novel Candidate Genes, and Response to Precision Therapy., PMID:32086287
Ser100-Phosphorylated RORα Orchestrates CAR and HNF4α to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6., PMID:31924695
Absence of Islet Autoantibodies and Modestly Raised Glucose Values at Diabetes Diagnosis Should Lead to Testing for MODY: Lessons From a 5-Year Pediatric Swedish National Cohort Study., PMID:31704690
Analysis of the transcription factors and their regulatory roles during a step-by-step differentiation of induced pluripotent stem cells into hepatocyte-like cells., PMID:31612883
Isolation and Expansion of Rat Hepatocytic Progenitor Cells., PMID:30536088
Autoantibodies against ZnT8 are rare in Central-European LADA patients and absent in MODY patients, including those positive for other autoantibodies., PMID:30377089
IL-23 enhances the malignant properties of hepatoma cells by attenuation of HNF4α., PMID:29983862
Site-Specific Fluorescent Labeling of Antibodies and Diabodies Using SpyTag/SpyCatcher System for In Vivo Optical Imaging., PMID:29948640
A novel INS mutation in a family with maturity-onset diabetes of the young: Variable insulin secretion and putative mechanisms., PMID:29633446
Pharmacogenetics of the anti-HCV drug sofosbuvir: a preliminary study., PMID:29509884
More than kin, less than kind: one family and the many faces of diabetes in youth., PMID:29412391
Can Biomarkers Help Target Maturity-Onset Diabetes of the Young Genetic Testing in Antibody-Negative Diabetes?, PMID:29355436
Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients., PMID:28701371
Comprehensive screening for monogenic diabetes in 89 Japanese children with insulin-requiring antibody-negative type 1 diabetes., PMID:28597946
DNA methylation controls unmethylated transcription start sites in the genome in trans., PMID:28470094
Monogenic Diabetes Accounts for 6.3% of Cases Referred to 15 Italian Pediatric Diabetes Centers During 2007 to 2012., PMID:28323911
[Effects of pargyline on histone methylation in promoter and enhancer regions and transcription of CYP3A4/3A7]., PMID:29911787
Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry., PMID:27913849
Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors., PMID:27820600
Differentiation of human foreskin fibroblast-derived induced pluripotent stem cells into hepatocyte-like cells., PMID:27569862
Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α., PMID:27501760
Treating young adults with type 2 diabetes or monogenic diabetes., PMID:27432078
Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes., PMID:27271189
Pregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells., PMID:26232425
Characteristics of maturity onset diabetes of the young in a large diabetes center., PMID:26059258
Clinical and molecular characterization of maturity onset-diabetes of the young caused by hepatocyte nuclear factor-4 alpha mutation: red flags for prediction of the diagnosis., PMID:25266181
HNF-4α regulates expression of human ornithin carbamoyltransferase through interaction with two positive cis-acting regulatory elements located in the proximal promoter., PMID:25056436
Upregulation of hepatic melanocortin 4 receptor during rat liver regeneration., PMID:24433867
Positivity for islet cell autoantibodies in patients with monogenic diabetes is associated with later diabetes onset and higher HbA1c level., PMID:24102923
For research use only. Not for human or drug use.
