Catalog No.
RHE18302
Species reactivity
Human, Rat
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000
Target
Neuronal acetylcholine receptor subunit alpha-7, NACHRA7, CHRNA7
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P36544
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3K05
Nicotinic Acetylcholine Receptor Expression in Merkel Cell Carcinoma Is Associated With Clinical and Histopathologic Parameters., PMID:39814046
Stress Affects Mast Cell Proteases in Murine Skin in a Model of Atopic Dermatitis-like Allergic Inflammation., PMID:38891925
Vagus nerve stimulation modulates distinct acetylcholine receptors on B cells and limits the germinal center response., PMID:38669336
Nicotinic acetylcholine receptor activation induces BACE1 transcription via the phosphorylation and stabilization of nuclear SP1., PMID:38110001
An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies., PMID:37749098
Network Pharmacological Study on the Mechanism of Cynanchum paniculatum (Xuchangqing) in the Treatment of Bungarus multicinctus Bites., PMID:35837378
CHRFAM7A: A human specific fusion gene, accounts for the translational gap for cholinergic strategies in Alzheimer's disease., PMID:32818803
Alpha7 acetylcholine receptor autoantibodies are rare in sera of patients diagnosed with schizophrenia or bipolar disorder., PMID:30521579
CHRFAM7A alters binding to the neuronal alpha-7 nicotinic acetylcholine receptor., PMID:30308236
Evaluating Commercially Available Antibodies for Rat α7 Nicotinic Acetylcholine Receptors., PMID:28763248
Nicotine stimulates collagen type I expression in lung via α7 nicotinic acetylcholine receptors., PMID:28576119
Nicotine reverses hypofrontality in animal models of addiction and schizophrenia., PMID:28112735
Suitability of Nicotinic Acetylcholine Receptor α7 and Muscarinic Acetylcholine Receptor 3 Antibodies for Immune Detection: Evaluation in Murine Skin., PMID:25673288
CHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury., PMID:25473097
Synaptic pattern of nicotinic acetylcholine receptor α7 and β2 subunits on the direction-selective retinal ganglion cells in the postnatal mouse retina., PMID:24631336
Lateral mobility of presynaptic α7-containing nicotinic receptors and its relevance for glutamate release., PMID:24155310
Neuroprotection of rat retinal ganglion cells mediated through alpha7 nicotinic acetylcholine receptors., PMID:23402849
Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity., PMID:23353645
Cholinergic receptor alterations in the brain stem of spinal cord injured rats., PMID:23184186
Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages., PMID:23028093
Atomic force microscopy to characterize binding properties of α7-containing nicotinic acetylcholine receptors on neurokinin-1 receptor-expressing medullary respiratory neurons., PMID:22962286
Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function., PMID:22823388
In utero nicotine exposure promotes M2 activation in neonatal mouse alveolar macrophages., PMID:22562289
Role of antibodies to neuronal α7-acetylcholine receptors in myasthenia., PMID:22451872
Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2+ accumulation and cytochrome c release: study on isolated mitochondria., PMID:22359587
[Nicotine effects on mitochondria membrane potential: participation of nicotinic acetylcholine receptors]., PMID:22276424
α7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage., PMID:22207510
NNK promotes migration and invasion of lung cancer cells through activation of c-Src/PKCι/FAK loop., PMID:22178655
The effect of nicotine on anti-vascular endothelial growth factor therapy in a mouse model of neovascular age-related macular degeneration., PMID:22088983
Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis., PMID:21784975
The presence and origin of autoantibodies against α4 and α7 nicotinic acetylcholine receptors in the human blood: possible relevance to Alzheimer's pathology., PMID:21593571
[Autoantibodies to α7-subunit of neuronal acetylcholine receptor in children with traumatic brain injury]., PMID:21512503
Antibodies against extracellular domains of α4 and α7 subunits alter the levels of nicotinic receptors in the mouse brain and affect memory: possible relevance to Alzheimer's pathology., PMID:21321393
Differential involvement of α4β2, α7 and α9α10 nicotinic acetylcholine receptors in B lymphocyte activation in vitro., PMID:21146628
Granulocyte colony-stimulating factor attenuates chronic neuroinflammation in the brain of amyloid precursor protein transgenic mice: an Alzheimer's disease mouse model., PMID:20926003
Vitamin D3 restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats., PMID:20655720
Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats., PMID:20637830
Role of the cholinergic nervous system in rheumatoid arthritis: aggravation of arthritis in nicotinic acetylcholine receptor α7 subunit gene knockout mice., PMID:20511609
Vaccination with peptide 173-193 of acetylcholine receptor α7-subunit prevents memory loss in olfactory bulbectomized mice., PMID:20413883
The role of alpha7 nicotinic acetylcholine receptors in B lymphocyte activation., PMID:20387628
Antigenic structure of the human muscle nicotinic acetylcholine receptor main immunogenic region., PMID:19705087
Cell specific synovial expression of nicotinic alpha 7 acetylcholine receptor in rheumatoid arthritis and psoriatic arthritis., PMID:19630919
Presence of alpha7 nicotinic acetylcholine receptors on dorsal root ganglion neurons proved using knockout mice and selective alpha-neurotoxins in histochemistry., PMID:19519780
Ric-3 chaperone-mediated stable cell-surface expression of the neuronal alpha7 nicotinic acetylcholine receptor in mammalian cells., PMID:19498422
The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: a possible role for a key neurotransmitter in synovial inflammation., PMID:19404936
Investigating the role of protein folding and assembly in cell-type dependent expression of alpha7 nicotinic receptors using a green fluorescent protein chimera., PMID:19368825
Is acetylcholine an autocrine/paracrine growth factor via the nicotinic alpha7-receptor subtype in the human colon cancer cell line HT-29?, PMID:19285065
Autoimmune autonomic ganglionopathy with late-onset encephalopathy., PMID:19028442
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) enhances invasiveness of lung cancer cells by up-regulating contactin-1 via the alpha7 nicotinic acetylcholine receptor/ERK signaling pathway., PMID:19027725
IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors., PMID:18848921
For research use only. Not for human or drug use.
