Catalog No.
RHE14901
Species reactivity
Human, Mouse, Rat
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:50-1:200, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
TCF-2, HNF-1-beta, TCF2, HNF1B, Variant hepatic nuclear factor 1, Homeoprotein LFB3, vHNF1, Hepatocyte nuclear factor 1-beta, HNF-1B, Transcription factor 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P35680
Applications
ELISA, FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3J92
Molecular and clinical profiles of pediatric monogenic diabetes subtypes: comprehensive genetic analysis of 138 patients., PMID:39504571
Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reveals Insights Into Disease Heterogeneity., PMID:39364395
Clinical and Laboratory Characteristics of MODY Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship., PMID:38665000
Screening of Mutations in Maturity-onset Diabetes of the Young-related Genes and RFX6 in Children with Autoantibody-negative Type 1 Diabetes Mellitus., PMID:38054414
Identification of monogenic variants in more than ten per cent of children without type 1 diabetes-related autoantibodies at diagnosis in the Finnish Pediatric Diabetes Register., PMID:36418577
Identification of Variants Responsible for Monogenic Forms of Diabetes in Brazil., PMID:35592779
Comprehensive genetic screening reveals wide spectrum of genetic variants in monogenic forms of diabetes among Pakistani population., PMID:34888019
Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program., PMID:34450036
Inhibition of hepatocyte nuclear factor 1β contributes to cisplatin nephrotoxicity via regulation of nf-κb pathway., PMID:33512774
HNF-1β as an immunohistochemical marker for distinguishing chromophobe renal cell carcinoma and hybrid oncocytic tumors from renal oncocytoma., PMID:32816058
Clinical and laboratory clues of maturity-onset diabetes of the young and determination of association with molecular diagnosis., PMID:32710514
Detection and analysis of glucose metabolism-related genes in childhood diabetes using targeted next-generation sequencing: In pediatric population-a hospital-based study., PMID:32266039
Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis., PMID:31016646
Maturity-onset diabetes of the young type 5 uncovered during pregnancy with a long-term diagnosis of type 1 diabetes., PMID:30860651
Distinguishing the progression of an endometrioma: Benign or malignant?, PMID:30245441
COL4A3 Gene Variants and Diabetic Kidney Disease in MODY., PMID:30012629
Expression of Markers of Müllerian Clear Cell Carcinoma in Primary Cervical and Vaginal Gastric-type Adenocarcinomas., PMID:29901522
A novel INS mutation in a family with maturity-onset diabetes of the young: Variable insulin secretion and putative mechanisms., PMID:29633446
Heterogeneity of SOX9 and HNF1β in Pancreatic Ducts Is Dynamic., PMID:29478894
From Waldenström's macroglobulinemia to aggressive diffuse large B-cell lymphoma: a whole-exome analysis of abnormalities leading to transformation., PMID:28841204
Comprehensive screening for monogenic diabetes in 89 Japanese children with insulin-requiring antibody-negative type 1 diabetes., PMID:28597946
Purification of Definitive Endoderm Generated from Pluripotent Stem Cells by Magnetic Cell Sorting., PMID:28152181
Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry., PMID:27913849
Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors., PMID:27820600
Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes., PMID:27271189
Maturity onset diabetes of the young: clinical characteristics and outcome after kidney and pancreas transplantation in MODY3 and RCAD patients: a single center experience., PMID:22432796
[Clinical parameters for molecular testing of Maturity Onset Diabetes of the Young (MODY)]., PMID:21590629
The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps., PMID:21281489
Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expression., PMID:21098558
HNF1B-related diabetes triggered by renal transplantation., PMID:19639018
A-beta-subtype of ketosis-prone diabetes is not predominantly a monogenic diabetic syndrome., PMID:19228875
HNF1B abnormality (mature-onset diabetes of the young 5) in children and adolescents: high prevalence in autoantibody-negative type 1 diabetes with kidney defects., PMID:18955710
Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells., PMID:15486044
Etiological investigation of diabetes in young adults presenting with apparent type 2 diabetes., PMID:12832318
[Clinical, metabolic, immunologic and genotypic characteristics in non-pediatric patients with type 1A diabetes mellitus. Onset and short-term prognosis]., PMID:12605834
An enhancer activates the pig lactase phlorizin hydrolase promoter in intestinal cells., PMID:12594046
Identifying hepatic nuclear factor 1alpha mutations in children and young adults with a clinical diagnosis of type 1 diabetes., PMID:12547858
Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutations., PMID:12530534
Down-regulation of alpha class glutathione S-transferase by interleukin-1beta in human intestinal epithelial cells (Caco-2) in culture., PMID:12386123
Hepatocyte nuclear factor (HNF)-4 alpha/gamma, HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene., PMID:12220531
Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells., PMID:12031966
Prevalence of the missense mutation Gly574Ser in the hepatocyte nuclear factor-1alpha in Africans with diabetes., PMID:11938027
Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release., PMID:11875061
Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes., PMID:11756330
Familial early-onset type 2 diabetes in Chinese patients: obesity and genetics have more significant roles than autoimmunity., PMID:11315828
Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha., PMID:11284743
Early-onset type 2 diabetes: metabolic and genetic characterization in the mexican population., PMID:11232004
Insulin secretion and insulin sensitivity in diabetic subgroups: studies in the prediabetic and diabetic state., PMID:11151756
Inhibitor of the tissue-specific transcription factor HNF4, a potential regulator in early Xenopus development., PMID:11073969
Octamer transcription factor-1 enhances hepatic nuclear factor-1alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter., PMID:10779377
For research use only. Not for human or drug use.
