Catalog No.
RHD88301
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200
Target
Dual specificity phosphatase Cdc25A, M-phase inducer phosphatase 1, CDC25A
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P30304
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3H98
Differential anti-viral response to respiratory syncytial virus A in preterm and term infants., PMID:38447274
Regulatory mechanism of interaction between Y-box-binding protein 1 and heterogenous nuclear ribonucleoprotein K in cell division cycle 25a signal pathway and lung cancer metastasis., PMID:38279484
Nasal polyp antibody-secreting cells display proliferation signature in aspirin-exacerbated respiratory disease., PMID:37898408
In search of autophagy biomarkers in breast cancer: Receptor status and drug agnostic transcriptional changes during autophagy flux in cell lines., PMID:34990474
Involvement of Myt1 kinase in the G2 phase of the first cell cycle in Xenopus laevis., PMID:31128913
Radiotherapy induces cell cycle arrest and cell apoptosis in nasopharyngeal carcinoma via the ATM and Smad pathways., PMID:28799829
Phosphorylation of CDC25A on SER283 in late S/G2 by CDK/cyclin complexes accelerates mitotic entry., PMID:27580187
De novo resistance biomarkers to anti-HER2 therapies in HER2-positive breast cancer., PMID:26257318
Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma., PMID:24838526
Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression., PMID:24211536
Generation of high-producing cell lines by overexpression of cell division cycle 25 homolog A in Chinese hamster ovary cells., PMID:23810665
CDC25A protein stability represents a previously unrecognized target of HER2 signaling in human breast cancer: implication for a potential clinical relevance in trastuzumab treatment., PMID:23730206
Inorganic arsenic impairs proliferation and cytokine expression in human primary T lymphocytes., PMID:22683347
A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells., PMID:21035837
A novel N-hydroxy-N'-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C)., PMID:20849828
Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7., PMID:20831893
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair., PMID:20501833
Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes., PMID:20500813
JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint., PMID:20220133
Xenografting of testicular tissue from an infant human donor results in accelerated testicular maturation., PMID:20172867
The polo-like kinase 1 regulates CDC25B-dependent mitosis entry., PMID:19185590
Cell cycle dysregulation influences survival in high risk breast cancer patients., PMID:18665474
Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1., PMID:18590578
Constitutive overexpression of CDC25A in primary human mammary epithelial cells results in both defective DNA damage response and chromosomal breaks at fragile sites., PMID:18566993
Chloramphenicol induces abnormal differentiation and inhibits apoptosis in activated T cells., PMID:18559535
[Prognostic value of CDC25 phosphatases expression in laryngeal cancer]., PMID:18551998
Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics., PMID:17019715
Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins., PMID:16477038
Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway., PMID:15561098
Regulation of lung cancer cell growth and invasiveness by beta-TRCP., PMID:15536641
The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway., PMID:15342622
ATR and ATM regulate the timing of DNA replication origin firing., PMID:15220931
Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery., PMID:15210709
[Analysis of transient G1/S arrest in E1A+E1B-19kDa transformed cells after ionizing radiation]., PMID:15027353
Phosphorylations of cyclin-dependent kinase 2 revisited using two-dimensional gel electrophoresis., PMID:14551212
Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint., PMID:12963847
Redox regulation of Cdc25C., PMID:11925443
Spatial analysis of key signaling proteins by high-content solid-phase cytometry in Hep3B cells treated with an inhibitor of Cdc25 dual-specificity phosphatases., PMID:11274178
The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease., PMID:11106571
Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity., PMID:10611320
A maternal form of the phosphatase Cdc25A regulates early embryonic cell cycles in Xenopus laevis., PMID:10433828
Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-beta-induced cell cycle arrest of gastric carcinoma cells., PMID:10376964
Mechanism of induction of follicular atresia after equine chorionic gonadotrophin (eCG) antisera treatment in hypophysectomized eCG-injected hamster model: possible involvement of c-myc and cdc25., PMID:10362287
mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25., PMID:9806630
The cdc25B phosphatase is essential for the G2/M phase transition in human cells., PMID:9683638
Ginsenoside-Rg5 suppresses cyclin E-dependent protein kinase activity via up-regulating p21Cip/WAF1 and down-regulating cyclin E in SK-HEP-1 cells., PMID:9137450
Ginsenoside-Rh2 blocks the cell cycle of SK-HEP-1 cells at the G1/S boundary by selectively inducing the protein expression of p27kip1., PMID:9018101
S-phase induction by adenovirus E1A requires activation of cdc25a tyrosine phosphatase., PMID:8700513
Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition., PMID:7523110
Cdc25A is a novel phosphatase functioning early in the cell cycle., PMID:8156993
For research use only. Not for human or drug use.
