Catalog No.
RHD76102
Species reactivity
Human, Rat
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
Low molecular mass protein 7, Macropain subunit C13, Really interesting new gene 10 protein, RING10, LMP7, Y2, Proteasome component C13, PSMB5i, Multicatalytic endopeptidase complex subunit C13, Proteasome subunit beta-5i, Proteasome subunit beta type-8, PSMB8
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P28062
Applications
ELISA, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3H50
Immunohistochemical Identification and Assessment of the Location of Immunoproteasome Subunits LMP2 and LMP7 in Acquired Cholesteatoma., PMID:37762439
Efficacy, safety, and molecular response predictors of oral ixazomib and short-course rituximab in untreated iNHL., PMID:36385536
Myositis with sarcoplasmic inclusions in Nakajo-Nishimura syndrome: a genetic inflammatory myopathy., PMID:32144790
Bioinformatics Analysis of Potential Key Genes in Trastuzumab-Resistant Gastric Cancer., PMID:31949544
Proteasomal adaptations underlying carfilzomib-resistance in human bone marrow plasma cells., PMID:31595669
Overexpression of immunoproteasome low-molecular-mass polypeptide 7 and inhibiting role of next-generation proteasome inhibitor ONX 0912 on cell growth in glioma., PMID:31503210
Whole exome sequencing approach to childhood onset familial erythrodermic psoriasis unravels a novel mutation of CARD14 requiring unusual high doses of ustekinumab., PMID:31286971
Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens., PMID:30343902
Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation., PMID:29229189
ONX-0914, a selective inhibitor of immunoproteasome, ameliorates experimental autoimmune myasthenia gravis by modulating humoral response., PMID:28844501
Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?, PMID:24756968
Rescue of MHC-1 antigen processing machinery by down-regulation in expression of IGF-1 in human glioblastoma cells., PMID:23526983
A putative role for the immunoproteasome in the maintenance of pluripotency in human embryonic stem cells., PMID:22532526
The immunoproteasome in steatohepatitis: its role in Mallory-Denk body formation., PMID:21256843
A novel role for the immunoproteasome in retinal function., PMID:20881299
Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer., PMID:19243813
Age-related increase in the immunoproteasome content in rat hippocampus: molecular and functional aspects., PMID:19012754
[Immune proteasomes in the developing rat spleen]., PMID:18949853
Autoimmune reactivity against the 20S-proteasome includes immunosubunits LMP2 (beta1i), MECL1 (beta2i) and LMP7 (beta5i)., PMID:18375405
The ubiquitin-proteasome system plays essential roles in presenting an 8-mer CTL epitope expressed in APC to corresponding CD8+ T cells., PMID:16569681
Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses., PMID:16549793
Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors., PMID:16322289
Development and characterization of human constitutive proteasome and immunoproteasome subunit-specific monoclonal antibodies., PMID:16101829
Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway., PMID:16002705
Coordinated downregulation of the antigen presentation machinery and HLA class I/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer., PMID:15455355
Antigen-processing machinery in human dendritic cells: up-regulation by maturation and down-regulation by tumor cells., PMID:15265880
Neuronal induction of the immunoproteasome in Huntington's disease., PMID:14684867
IFN-alpha mediates the up-regulation of HLA class I on melanoma cells without switching proteasome to immunoproteasome., PMID:14645150
Total loss of MHC class I in colorectal tumors can be explained by two molecular pathways: beta2-microglobulin inactivation in MSI-positive tumors and LMP7/TAP2 downregulation in MSI-negative tumors., PMID:12694570
Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation., PMID:11717192
Molecular studies and NK cell function of a new case of TAP2 homozygous human deficiency., PMID:11529920
Introduction of tapasin gene restores surface expression of HLA class I molecules, but not antigen presentation of an HIV envelope peptide in a hepatoma cell line., PMID:11444872
Accessory proteins that control the assembly of MHC molecules with peptides., PMID:11444385
TAP1 down-regulation in primary melanoma lesions: an independent marker of poor prognosis., PMID:11241306
IFN-beta mediates coordinate expression of antigen-processing genes in RSV-infected pulmonary epithelial cells., PMID:11159003
Association of immunoproteasomes with the endoplasmic reticulum., PMID:11104664
Tissue distribution of constitutive proteasomes, immunoproteasomes, and PA28 in rats., PMID:11032729
Gene transfer of human interferon gamma complementary DNA into a renal cell carcinoma line enhances MHC-restricted cytotoxic T lymphocyte recognition but suppresses non-MHC-restricted effector cell activity., PMID:10849555
Up-regulation of the proteasome subunit LMP7 in tissues of endotoxemic rats., PMID:10779048
Invasion by Salmonella typhimurium induces increased expression of the LMP, MECL, and PA28 proteasome genes and changes in the peptide repertoire of HLA-B27., PMID:9746558
Development and characterization of mouse anti-human LMP2, LMP7, TAP1 and TAP2 monoclonal antibodies., PMID:9510369
Characterization of rabbit antisera elicited with human LMP2- and LMP7-specific peptides and recombinant proteins., PMID:9458109
Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits., PMID:9311996
Proteasome subunits, low-molecular-mass polypeptides 2 and 7 are hyperexpressed by target cells in autoimmune thyroid disease but not in insulin-dependent diabetes mellitus: implications for autoimmunity., PMID:9271825
Delineation of the subunit composition of human proteasomes using antisera against the major histocompatibility complex-encoded LMP2 and LMP7 subunits., PMID:8278381
Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules., PMID:1436094
Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation., PMID:1299222
Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits., PMID:1429565
For research use only. Not for human or drug use.
