Catalog No.
RHD73610
Species reactivity
Human, Mouse, Rat
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100
Target
Microtubule-associated protein 2 kinase, p44-MAPK, Extracellular signal-regulated kinase 1, ERK1, MAPK3, MAP kinase isoform p44, Mitogen-activated protein kinase 3, ERK-1, PRKM3, Insulin-stimulated MAP2 kinase, p44-ERK1, MAPK 3, MAP kinase 3, ERT2, MAP kinase isoform p42, PRKM2, Extracellular signal-regulated kinase 2, MAPK 2, Mitogen-activated protein kinase 1, PRKM1, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 1, MAP kinase 2, ERK2, ERT1, ERK-2, MAPK 1, MAPK1, Phospho-ERK1 (Tyr222/Tyr205), Phospho-ERK2 (Tyr222/Tyr205)
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P27361, P28482
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3H25
E53, E96, D162, E247 and D322 in Ca2+-binding domains of annexin A2 are essential for regulating intracellular [Ca2+] and crystal adhesion to renal cells via ERK1/2 and JNK signaling pathways., PMID:40189002
Tirbanibulin decreases cell proliferation and downregulates protein expression of oncogenic pathways in human papillomavirus containing HeLa cells., PMID:38967656
Regulatory role of RGMb in lung injury promoted by the combination of carbon ion irradiation and anti-PD-1 antibody through Erk1/2 and p38 MAPK pathways., PMID:38042034
Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus., PMID:37678448
Neuroprotective and Disease-Modifying Effects of the Triazinetrione ACD856, a Positive Allosteric Modulator of Trk-Receptors for the Treatment of Cognitive Dysfunction in Alzheimer's Disease., PMID:37446337
Multiplexed Fluorescence Plate Reader In Situ Protein Expression Assay in Apoptotic HepG2 Cells., PMID:37047536
High concentrations of Porphyromonas gingivalis-LPS downregulate Tlr4 and modulate phosphorylation of ERK and AKT in murine cementoblasts., PMID:36400339
AREG is involved in scleral remodeling in form-deprivation myopia via the ERK1/2-MMP-2 pathway., PMID:35436023
EGF Receptor Transactivation by Endothelin-1 Increased CHSY-1 Mediated by NADPH Oxidase and Phosphorylation of ERK1/2., PMID:34837677
Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway., PMID:34516351
Identification of 5-Hydroxymethylfurfural (5-HMF) as an Active Component Citrus Jabara That Suppresses FcεRI-Mediated Mast Cell Activation., PMID:32252468
AAVshRNA-mediated PTEN knockdown in adult neurons attenuates activity-dependent immediate early gene induction., PMID:31707081
Combining fluorescent cell barcoding and flow cytometry-based phospho-ERK1/2 detection at short time scales in adherent cells., PMID:30277662
G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Differentiation in Response to Lysolecithin-Induced Demyelination., PMID:29540737
CCL21/CCR7 interaction promotes cellular migration and invasion via modulation of the MEK/ERK1/2 signaling pathway and correlates with lymphatic metastatic spread and poor prognosis in urinary bladder cancer., PMID:28534984
MAPK Assays in Arabidopsis MAMP-PRR Signal Transduction., PMID:28220422
Anti-RAGE antibody selectively blocks acute systemic inflammatory responses to LPS in serum, liver, CSF and striatum., PMID:28088642
Intracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells., PMID:26988990
Phospho-ERK1/2 levels in cancer cell nuclei predict responsiveness to radiochemotherapy of rectal adenocarcinoma., PMID:26416417
Bee Venom Protects against Rotenone-Induced Cell Death in NSC34 Motor Neuron Cells., PMID:26402700
Effect of TNFRSF6B neutralization antibody on cell growth suppression and apoptosis induction in glioma cells., PMID:25997959
Artemin Immunotherapy Is Effective in Preventing and Reversing Cystitis-Induced Bladder Hyperalgesia via TRPA1 Regulation., PMID:25892657
Bacopa monnieri protects SH-SY5Y cells against tert-Butyl hydroperoxide-induced cell death via the ERK and PI3K pathways., PMID:29152617
The effect of estrogen on the proliferation of endometrial cancer cells is mediated by ERRγ through AKT and ERK1/2., PMID:25068805
Deletion of atbf1/zfhx3 in mouse prostate causes neoplastic lesions, likely by attenuation of membrane and secretory proteins and multiple signaling pathways., PMID:24934715
Extracellular signal-regulated kinase 1/2 signaling pathway is required for endometrial decidualization in mice and human., PMID:24086495
Functional significance of the novel H-RAS gene mutation M72I in a patient with medullary thyroid cancer., PMID:23934677
Leptin and mitogen-activated protein kinase (MAPK) in oocytes of sows and gilts., PMID:23602489
Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects., PMID:23261543
Insulin promotes T cell recovery in a murine model of autoimmune myocarditis., PMID:23199322
Effects of intravitreal insulin and insulin signaling cascade inhibitors on emmetropization in the chick., PMID:23112573
Pleiotrophin (PTN) expression and function and in the mouse mammary gland and mammary epithelial cells., PMID:23077670
Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity., PMID:22987565
Effect of tamoxifen on extracellular signal-regulated kinases in the urethra of castrated female rats., PMID:22721636
Activation of extracellular-signal regulated kinase by epidermal growth factor is potentiated by cAMP-elevating agents in primary cultures of adult rat hepatocytes., PMID:21963493
Liver fibrosis protects mice from acute hepatocellular injury., PMID:21945831
Cyclic strain upregulates VEGF and attenuates proliferation of vascular smooth muscle cells., PMID:21929819
PDGF-BB and TGF-{beta}1 on cross-talk between endothelial and smooth muscle cells in vascular remodeling induced by low shear stress., PMID:21245329
Cytosolic and calcium-independent phospholipase A(2) mediate glioma-enhanced proangiogenic activity of brain endothelial cells., PMID:21094175
Sprouty2 downregulates angiogenesis during mouse skin wound healing., PMID:21076020
ERK1/2 signaling pathway in mast cell activation-induced sensitization of esophageal nodose C-fiber neurons., PMID:21073620
The anti-oestrogen fulvestrant (ICI 182,780) reduces the androgen receptor expression, ERK1/2 phosphorylation and cell proliferation in the rat ventral prostate., PMID:20874728
Changes in mitogen-activated protein kinase in cerebellar granule neurons by polybrominated diphenyl ethers and polychlorinated biphenyls., PMID:20171977
ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis., PMID:19846573
Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice., PMID:19706788
Fibrinogen binding to ICAM-1 promotes EGFR-dependent mucin production in human airway epithelial cells., PMID:19429776
Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies., PMID:19278954
Neuroprotective effects of ugonin K on hydrogen peroxide-induced cell death in human neuroblastoma SH-SY5Y cells., PMID:18841465
Differential activation of extracellular signal-regulated kinase 1 and a related complex in neuronal nuclei., PMID:18392730
Involvement of PI3K/Akt signaling pathway in hepatocyte growth factor-induced migration of uveal melanoma cells., PMID:18234991
For research use only. Not for human or drug use.
