Catalog No.
RHD66203
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:50-1:200, IHC: 1:200-1:1000
Target
CXCR-7, RDC1, C-X-C chemokine receptor type 7, RDC-1, Chemokine orphan receptor 1, G-protein coupled receptor 159, Atypical chemokine receptor 3, CMKOR1, CXCR7, GPR159, G-protein coupled receptor RDC1 homolog, ACKR3, CXC-R7
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P25106
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3G71
Chemokine receptor CXCR7 antagonism ameliorates cardiac and renal fibrosis induced by mineralocorticoid excess., PMID:39505939
Investigational CXCR4 inhibitors in early phase development for the treatment of hematological malignancies., PMID:39096094
Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites., PMID:39053189
CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity., PMID:38898023
Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies., PMID:38816420
CXCL14 as a Key Regulator of Neuronal Development: Insights from Its Receptor and Multi-Omics Analysis., PMID:38338930
Synergy by Ristocetin and CXCL12 in Human Platelet Activation: Divergent Regulation by Rho/Rho-Kinase and Rac., PMID:37298667
C-X-C chemokine receptor type 7 antibody enhances neural plasticity after ischemic stroke., PMID:36926722
Exploring the CXCR4/CXCR7/CXCL12 Axis in Primary Desmoid Tumors., PMID:36748819
Identification and classification of distinct surface markers of T regulatory cells., PMID:36741366
Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins., PMID:36138170
Selective Elimination of Senescent Fibroblasts by Targeting the Cell Surface Protein ACKR3., PMID:35742971
CXCL12 inhibits hair growth through CXCR4., PMID:35462338
Advances in Chemokine Signaling Pathways as Therapeutic Targets in Glioblastoma., PMID:34203660
Tissue factor pathway inhibitor upregulates CXCR7 expression and enhances CXCL12-mediated migration in chronic lymphocytic leukemia., PMID:33664415
CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells., PMID:33258800
Synergistic effect of collagen and CXCL12 in the low doses on human platelet activation., PMID:33119719
Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide., PMID:32579945
Advances in CXCR7 Modulators., PMID:32098047
Expression and Functional Analysis of CXCL12 and Its Receptors in Human Term Trophoblast Cells., PMID:32046406
The CXCL12-CXCR4/CXCR7 axis as a mechanism of immune resistance in gastrointestinal malignancies., PMID:31874281
Effects of CXCR7-neutralizing antibody on neurogenesis in the hippocampal dentate gyrus and cognitive function in the chronic phase of cerebral ischemia., PMID:31823888
FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice., PMID:31662319
From Insight to Modulation of CXCR4 and ACKR3 (CXCR7) Function., PMID:31624136
Antibodies Targeting Chemokine Receptors CXCR4 and ACKR3., PMID:31481460
Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans., PMID:31211835
The role of vascular endothelial growth factor receptor 1 tyrosine kinase signaling in bleomycin-induced pulmonary fibrosis., PMID:31176171
Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a phase IIa study in patients with relapsed/refractory chronic lymphocytic leukemia., PMID:31097627
Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice., PMID:30956944
CXCR7 is not obligatory for CXCL12-CXCR4-induced epithelial-mesenchymal transition in human ovarian cancer., PMID:30259564
Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration., PMID:29980568
A Chimeric Antibody against ACKR3/CXCR7 in Combination with TMZ Activates Immune Responses and Extends Survival in Mouse GBM Models., PMID:29606504
CXCR7/ACKR3-targeting ligands interfere with X7 HIV-1 and HIV-2 entry and replication in human host cells., PMID:29560468
Modulatory effects of trophoblast-secreted CXCL12 on the migration and invasion of human first-trimester decidual epithelial cells are mediated by CXCR4 rather than CXCR7., PMID:29499763
MicroRNA-126/stromal cell-derived factor 1/C-X-C chemokine receptor type 7 signaling pathway promotes post-stroke angiogenesis of endothelial progenitor cell transplantation., PMID:29393458
Critical involvement of atypical chemokine receptor CXCR7 in allergic airway inflammation., PMID:29250768
Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using 64Cu-plerixafor PET., PMID:29088715
[Expression of CXCR7 in Acute Monocytic Leukemia and Its Effects on THP-1 Cell Functions]., PMID:29070099
Inhibition of CXCL12/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma., PMID:28544785
CXCR7 maintains osteosarcoma invasion after CXCR4 suppression in bone marrow microenvironment., PMID:28468584
Epigenetic upregulation of CXCL12 expression mediates antitubulin chemotherapeutics-induced neuropathic pain., PMID:28072604
[Treatment for rheumatoid arthritis by chemokine blockade]., PMID:27320932
Evidence of an interaction between TGF-β1 and the SDF-1/CXCR4/CXCR7 axis in human platelets., PMID:27314628
The prognostic significance and impact of the CXCR4-CXCR7-CXCL12 axis in primary cutaneous melanoma., PMID:27167239
Targeted Imaging of the Atypical Chemokine Receptor 3 (ACKR3/CXCR7) in Human Cancer Xenografts., PMID:26912435
Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis., PMID:26779814
Commercially available antibodies directed against α-adrenergic receptor subtypes and other G protein-coupled receptors with acceptable selectivity in flow cytometry experiments., PMID:26660071
CXCR7 suppression modulates microglial chemotaxis to ameliorate experimentally-induced autoimmune encephalomyelitis., PMID:26607112
Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4-CXCR7., PMID:26583329
Lipopolysaccharide Promotes Choroidal Neovascularization by Up-Regulation of CXCR4 and CXCR7 Expression in Choroid Endothelial Cell., PMID:26288180
For research use only. Not for human or drug use.
