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Anti-CXCR7/ACKR3 Antibody (R3G71)

Catalog #:   RHD66203 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: ELISA, FCM, IF, IHC
Accession: P25106
Overview

Catalog No.

RHD66203

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:50-1:200, IHC: 1:200-1:1000

Target

CXCR-7, RDC1, C-X-C chemokine receptor type 7, RDC-1, Chemokine orphan receptor 1, G-protein coupled receptor 159, Atypical chemokine receptor 3, CMKOR1, CXCR7, GPR159, G-protein coupled receptor RDC1 homolog, ACKR3, CXC-R7

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P25106

Applications

ELISA, FCM, IF, IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3G71

Data Image
  • Flow Cytometry
    Flow cytometric analysis of MCF-7 cells using CXCR7 mouse mAb (green) and negative control (red).
  • Immunofluorescence
    Immunofluorescence analysis of Hela cells using CXCR7 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CXCR7 mouse mAb with DAB staining.
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CXCR7 mouse mAb with DAB staining.
References

Chemokine receptor CXCR7 antagonism ameliorates cardiac and renal fibrosis induced by mineralocorticoid excess., PMID:39505939

Investigational CXCR4 inhibitors in early phase development for the treatment of hematological malignancies., PMID:39096094

Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites., PMID:39053189

CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity., PMID:38898023

Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies., PMID:38816420

CXCL14 as a Key Regulator of Neuronal Development: Insights from Its Receptor and Multi-Omics Analysis., PMID:38338930

Synergy by Ristocetin and CXCL12 in Human Platelet Activation: Divergent Regulation by Rho/Rho-Kinase and Rac., PMID:37298667

C-X-C chemokine receptor type 7 antibody enhances neural plasticity after ischemic stroke., PMID:36926722

Exploring the CXCR4/CXCR7/CXCL12 Axis in Primary Desmoid Tumors., PMID:36748819

Identification and classification of distinct surface markers of T regulatory cells., PMID:36741366

Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins., PMID:36138170

Selective Elimination of Senescent Fibroblasts by Targeting the Cell Surface Protein ACKR3., PMID:35742971

CXCL12 inhibits hair growth through CXCR4., PMID:35462338

Advances in Chemokine Signaling Pathways as Therapeutic Targets in Glioblastoma., PMID:34203660

Tissue factor pathway inhibitor upregulates CXCR7 expression and enhances CXCL12-mediated migration in chronic lymphocytic leukemia., PMID:33664415

CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells., PMID:33258800

Synergistic effect of collagen and CXCL12 in the low doses on human platelet activation., PMID:33119719

Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide., PMID:32579945

Advances in CXCR7 Modulators., PMID:32098047

Expression and Functional Analysis of CXCL12 and Its Receptors in Human Term Trophoblast Cells., PMID:32046406

The CXCL12-CXCR4/CXCR7 axis as a mechanism of immune resistance in gastrointestinal malignancies., PMID:31874281

Effects of CXCR7-neutralizing antibody on neurogenesis in the hippocampal dentate gyrus and cognitive function in the chronic phase of cerebral ischemia., PMID:31823888

FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice., PMID:31662319

From Insight to Modulation of CXCR4 and ACKR3 (CXCR7) Function., PMID:31624136

Antibodies Targeting Chemokine Receptors CXCR4 and ACKR3., PMID:31481460

Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans., PMID:31211835

The role of vascular endothelial growth factor receptor 1 tyrosine kinase signaling in bleomycin-induced pulmonary fibrosis., PMID:31176171

Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a phase IIa study in patients with relapsed/refractory chronic lymphocytic leukemia., PMID:31097627

Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice., PMID:30956944

CXCR7 is not obligatory for CXCL12-CXCR4-induced epithelial-mesenchymal transition in human ovarian cancer., PMID:30259564

Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration., PMID:29980568

A Chimeric Antibody against ACKR3/CXCR7 in Combination with TMZ Activates Immune Responses and Extends Survival in Mouse GBM Models., PMID:29606504

CXCR7/ACKR3-targeting ligands interfere with X7 HIV-1 and HIV-2 entry and replication in human host cells., PMID:29560468

Modulatory effects of trophoblast-secreted CXCL12 on the migration and invasion of human first-trimester decidual epithelial cells are mediated by CXCR4 rather than CXCR7., PMID:29499763

MicroRNA-126/stromal cell-derived factor 1/C-X-C chemokine receptor type 7 signaling pathway promotes post-stroke angiogenesis of endothelial progenitor cell transplantation., PMID:29393458

Critical involvement of atypical chemokine receptor CXCR7 in allergic airway inflammation., PMID:29250768

Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using 64Cu-plerixafor PET., PMID:29088715

[Expression of CXCR7 in Acute Monocytic Leukemia and Its Effects on THP-1 Cell Functions]., PMID:29070099

Inhibition of CXCL12/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma., PMID:28544785

CXCR7 maintains osteosarcoma invasion after CXCR4 suppression in bone marrow microenvironment., PMID:28468584

Epigenetic upregulation of CXCL12 expression mediates antitubulin chemotherapeutics-induced neuropathic pain., PMID:28072604

[Treatment for rheumatoid arthritis by chemokine blockade]., PMID:27320932

Evidence of an interaction between TGF-β1 and the SDF-1/CXCR4/CXCR7 axis in human platelets., PMID:27314628

The prognostic significance and impact of the CXCR4-CXCR7-CXCL12 axis in primary cutaneous melanoma., PMID:27167239

Targeted Imaging of the Atypical Chemokine Receptor 3 (ACKR3/CXCR7) in Human Cancer Xenografts., PMID:26912435

Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis., PMID:26779814

Commercially available antibodies directed against α-adrenergic receptor subtypes and other G protein-coupled receptors with acceptable selectivity in flow cytometry experiments., PMID:26660071

CXCR7 suppression modulates microglial chemotaxis to ameliorate experimentally-induced autoimmune encephalomyelitis., PMID:26607112

Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4-CXCR7., PMID:26583329

Lipopolysaccharide Promotes Choroidal Neovascularization by Up-Regulation of CXCR4 and CXCR7 Expression in Choroid Endothelial Cell., PMID:26288180

Datasheet
$ 220
Product specifications
50 μg 220 100 μg 350

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For research use only. Not for human or drug use.

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Anti-CXCR7/ACKR3 Antibody (R3G71) [RHD66203]
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