Catalog No.
RHD60803
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000
Target
Ribonucleotide reductase large subunit, RRM1, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleoside-diphosphate reductase large subunit, RR1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P23921
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3G51
Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1., PMID:38522514
Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas., PMID:37737247
[Morphological predictors of the efficacy of mitotane therapy in adrenocortical cancer]., PMID:36689714
Quantitative Multiplexed Proteomics Could Assist Therapeutic Decision Making in Non-Small Cell Lung Cancer Patients with Ambiguous ALK Test Results., PMID:34066104
Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein., PMID:32905837
Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology., PMID:30667370
Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals., PMID:29662239
Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function., PMID:28167528
RRM1, ERCC1 and TS1 Immunofluorescence Expression in Leiomyosarcoma: A Tissue Microarray Study with Clinical Outcome Correlation Analysis., PMID:26612755
Depletion of the SR-Related Protein TbRRM1 Leads to Cell Cycle Arrest and Apoptosis-Like Death in Trypanosoma brucei., PMID:26284933
Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions., PMID:25231164
Predictive biomarkers in patients with resected non-small cell lung cancer treated with perioperative chemotherapy., PMID:24293473
Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43)., PMID:23558684
Exploring biomarkers in head and neck cancer., PMID:22281752
Personalized therapy for non-small cell lung cancer: which drug for which patient?, PMID:22443647
Ribonucleotide reductase subunit M1 assessed by quantitative double-fluorescence immunohistochemistry predicts the efficacy of gemcitabine in biliary tract carcinoma., PMID:20811706
The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 (RRM1) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC)., PMID:20223551
Features of potentially predictive biomarkers of chemotherapeutic efficacy in small cell lung cancer., PMID:20107425
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)., PMID:19815002
Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma., PMID:19543324
The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53., PMID:14583450
Novel specificity of anti-U1A autoimmune patient sera., PMID:12542801
Identification of a nuclear protein in Trypanosoma brucei with homology to RNA-binding proteins from cis-splicing systems., PMID:9879882
Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter., PMID:7557993
Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal., PMID:7926751
For research use only. Not for human or drug use.
