Catalog No.
RHD40502
Species reactivity
Human, Mouse
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46, CD Man-6-P receptor, MPRD, M6PR, Cation-dependent mannose-6-phosphate receptor, MPR46
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P20645
Applications
ELISA, FCM, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3F71
Engineering IGF2 for Lysosome-targeting chimeras development to target drug-resistant membrane proteins in tumor therapy., PMID:39969096
Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan., PMID:39434219
Lysosome-targeting chimeras containing an endocytic signaling motif trigger endocytosis and lysosomal degradation of cell-surface proteins., PMID:39391383
Therapeutic antibody engineering for efficient targeted degradation of membrane proteins in lysosomes., PMID:38739989
Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins., PMID:38533506
Cation-independent mannose 6-phosphate receptor: From roles and functions to targeted therapies., PMID:38086445
IGF2 Peptide-Based LYTACs for Targeted Degradation of Extracellular and Transmembrane Proteins., PMID:38005242
Conjugation with glucagon like peptide-1 enables targeted protein degradation., PMID:37827016
Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility., PMID:37691832
Harnessing the Lysosomal Sorting Signals of the Cation-Independent Mannose-6-Phosphate Receptor for Targeted Degradation of Membrane Proteins., PMID:37552887
Super-resolution imaging of antibody-conjugated biodegradable periodic mesoporous organosilica nanoparticles for targeted chemotherapy of prostate cancer., PMID:37403617
Mannose 6-phosphate receptor-targeting antibodies preserve Fc receptor-mediated recycling., PMID:37169177
Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity., PMID:34721393
Novel Human Antibodies to Insulin Growth Factor 2 Receptor (IGF2R) for Radioimmunoimaging and Therapy of Canine and Human Osteosarcoma., PMID:34064450
CREG1 promotes lysosomal biogenesis and function., PMID:33966596
Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins., PMID:33791431
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation., PMID:33767387
Hsc70 Facilitates Mannose-6-Phosphate Receptor-Mediated Intracellular Trafficking and Enhances Endosomal Release of Phosphorothioate-Modified Antisense Oligonucleotides., PMID:33567234
Prosaposin in the rat oviductal epithelial cells., PMID:33242172
A radioligand binding assay for the insulin-like growth factor 2 receptor., PMID:32877466
Lysosome-targeting chimaeras for degradation of extracellular proteins., PMID:32728216
Exocytosis of Progeny Infectious Varicella-Zoster Virus Particles via a Mannose-6-Phosphate Receptor Pathway without Xenophagy following Secondary Envelopment., PMID:32493818
Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy., PMID:31793167
Detection and targeting insulin growth factor receptor type 2 (IGF2R) in osteosarcoma PDX in mouse models and in canine osteosarcoma tumors., PMID:31391495
Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay., PMID:30247460
Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay., PMID:28341739
Antibodies that neutralize cellular uptake of elosulfase alfa are not associated with reduced efficacy or pharmacodynamic effect in individuals with Morquio A syndrome., PMID:27789297
Hyperosmotic stress reduces melanin production by altering melanosome formation., PMID:25170965
Direct identification of ligand-receptor interactions on living cells and tissues., PMID:22983091
Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells., PMID:22768187
Biotherapeutic target or sink: analysis of the macrophage mannose receptor tissue distribution in murine models of lysosomal storage diseases., PMID:21416197
Gadkin: A novel link between endosomal vesicles and microtubule tracks., PMID:20798811
Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells., PMID:19725050
Rab22B's role in trans-Golgi network membrane dynamics., PMID:17678623
HCG increases trophoblast migration in vitro via the insulin-like growth factor-II/mannose-6 phosphate receptor., PMID:15749784
The protein tyrosine kinase Hck is located on lysosomal vesicles that are physically and functionally distinct from CD63-positive lysosomes in human macrophages., PMID:11801726
The role of phosphoinositide 3-kinase in the sorting and transport of newly synthesized tyrosinase-related protein-1 (TRP-1)., PMID:11764278
Localization of beta2-glycoprotein 1 in late endosomes of human endothelial cells., PMID:11372686
A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex., PMID:11106728
Antigen trafficking and accessory cell function in respiratory epithelial cells., PMID:10460754
High-affinity antibodies from hen's-egg yolks against human mannose-6-phosphate/insulin-like growth-factor-II receptor (M6P/IGFII-R): characterization and potential use in clinical cancer studies., PMID:10074924
Analysis of the interaction of procathepsin D activation peptide with breast cancer cells., PMID:9359488
Characterization of the Chlamydia trachomatis vacuole and its interaction with the host endocytic pathway in HeLa cells., PMID:9009339
Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells., PMID:7642697
Mannose-6-Phosphate Reductase, a Key Enzyme in Photoassimilate Partitioning, Is Abundant and Located in the Cytosol of Photosynthetically Active Cells of Celery (Apium graveolens L.) Source Leaves., PMID:12231825
Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion., PMID:1332979
Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes., PMID:1657400
The recycling itinerary of the 46 kDa mannose 6-phosphate receptor--Golgi to late endosomes--coincides with that of the 215 kDa M6PR., PMID:1964415
Transferrin receptors and cation-independent mannose-6-phosphate receptors deliver their ligands to two distinct subpopulations of multivesicular endosomes., PMID:2558886
For research use only. Not for human or drug use.
