Anti-Human Kappa Light Chain Antibody (R3F49)

Catalog No.

RHD36907

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IHC: 1:500-1:1000

Target

Ig kappa chain C region EU, Ig kappa chain C region, Ig kappa chain C region ROY, Immunoglobulin kappa constant, IGKC, Ig kappa chain C region TI, Ig kappa chain C region OU, Ig kappa chain C region CUM, Ig kappa chain C region AG

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01834

Applications

IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3F49

Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire., PMID:40501977

Human genetic variation shapes the antibody repertoire across B cell development., PMID:40475565

B cell receptor silencing reveals origin and dependencies of high-grade B cell lymphomas with MYC and BCL2 rearrangements., PMID:40402557

Considerations for use of humanized IgG1/4 Göttingen minipigs in safety assessment of antibody-based therapeutics., PMID:40398719

[Application of next-generation sequencing technology for the investigation of immunoglobulin variable region characteristics and their prognostic significance in patients with chronic lymphocytic leukemia]., PMID:40355356

Diagnosis On-Demand: Field Evaluation of Microfluidic Paper Device for the Detection of Asymptomatic Malaria., PMID:40350582

Comparison of CSF biomarkers in multiple sclerosis patients treated with natalizumab and rituximab., PMID:40345115

Clonal rearrangements of B and T lymphocytes in minor salivary gland biopsies of Sjögren's disease patients with a focus score of ≥1., PMID:40335403

Heterohybridomas producing human immunoglobulin light chains using CD138-selected bone marrow cells., PMID:40330075

[Localized AL amyloidosis]., PMID:40327620

Puriton attenuates the asthma severity in ovalbumin-induced murine model via balancing Th1/Th2 and inhibiting inflammation., PMID:40323927

Preparation and epitope mapping of monoclonal antibodies against African swine fever virus A238L protein., PMID:40311975

Proliferative glomerulonephritis with monoclonal immunoglobulin deposition coexisting with ANCA-associated glomerulonephritis: a case report., PMID:40308572

Paraneoplastic leukocytoclastic vasculitis mimicking ulcus cruris as rare initial manifestation of smoldering myeloma IgG kappa., PMID:40257478

A Case of Multiple Myeloma with Auer Rod-Like Inclusions in Plasma Cells., PMID:40209791

B-ALL with CD34 Negative and Surface Immunoglobulin Light Chain Restricted Expression., PMID:40209787

Identification of two conserved linear antigenic epitopes on the 2C protein of Senecavirus A., PMID:40209476

A two-column process for bispecific antibody purification based on MabSelect VL resin's strong byproduct removal capability., PMID:40200945

[Amyloid light-chain (AL) amyloidosis and follicular lymphoma: a case report]., PMID:40190438

Therapeutic potential of phytocompounds in rheumatoid arthritis: Molecular insights and clinical applications., PMID:40174276

Rapid affinity-based purification of multi-specific antibodies using Kappa Select and Protein L., PMID:40151946

Design of orthogonal constant domain interfaces to aid proper heavy/light chain pairing of bispecific antibodies., PMID:40126074

Kappa-free light chain as a practical alternative to oligoclonal bands in the diagnosis of multiple sclerosis., PMID:40086224

Diagnostic Utility of Kappa Free Light Chain Index in Adults With Inaugural Optic Neuritis., PMID:40085804

Prognostic relevance of immunoglobulin heavy chain rearrangement and immunoglobulin kappa light chain rearrangement in patients with diffuse large B cell lymphoma., PMID:40063611

Biological signatures in the Alzheimer's continuum discriminate between diagnosis-related and -unrelated associations to ATN categories., PMID:40046342

[BCMA/CS1 bispecific CAR-T cell therapy for multiple myeloma complicated with thrombocytopenia: a case report and literature review]., PMID:40032341

A case of IgG-type heavy chain amyloidosis with membranous nephropathy-like changes with long-term survival., PMID:40021557

Single-Chain Variable Fragments: Targeting Snake Venom Phospholipase A2 and Serine Protease., PMID:39998072

[Construction and identification of a sizeable naive human Fab phage display antibody library]., PMID:39965836

[Assessment of serum free light chains in patients with systemic lupus erythematosus]., PMID:39960251

Daratumumab treatment for kidney-involved light chain deposition disease prevents renal function progression: a case report with 3 years of follow-up and review of the literature., PMID:39949751

Oligoclonal bands and kappa free light chains: Competing parameters or complementary biomarkers?, PMID:39947571

A case of renal infiltration by Bence Jones protein kappa-producing lymphoplasmacytic lymphoma., PMID:39946076

Case report of glomerular histiocytosis associated with non-crystalline IgG-kappa paraproteinemia., PMID:39910484

Biomarkers of Intrathecal Synthesis May Be Associated with Cognitive Impairment at MS Diagnosis., PMID:39859538

Role of FOXO3a in LPS-induced inflammatory conditions in human dental pulp cells., PMID:39824385

Protocols for circulating neutrophil depletion in neonatal C57Bl/6 mice., PMID:39821323

Evaluation of an F Protein-Based Recombinant Protein for Immunization Against Respiratory Syncytial Virus., PMID:39791530

[IgAκ monoclonal immunoglobulin deposition disease: a case report]., PMID:39788598

Multiple myeloma-associated non-crystalline proximal tubulopathy and crystalline cast nephropathy: Biochemical and structural features of disease-causing monoclonal kappa light chains., PMID:39781602

Roles of immunoglobulin GM and KM allotypes and Fcγ receptor 2 A genotypes in humoral immunity to a conserved microbial polysaccharide in pulmonary diseases., PMID:39774260

Mice carrying the full-length human immunoglobulin loci produce antigen-specific human antibodies with the lambda light chain., PMID:39758990

50 Years of Antibody Numbering Schemes: A Statistical and Structural Evaluation Reveals Key Differences and Limitations., PMID:39727482

Baicalein tethers CD274/PD-L1 for autophagic degradation to boost antitumor immunity., PMID:39710370

EXPRESSION OF IMMUNOGLOBULIN LIGHT CHAIN GENES IN STEREOTYPED CASES FROM UKRAINIAN COHORT OF CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS., PMID:39704461

Diagnostic approach for multiple sclerosis: optimizing algorithms for intrathecal synthesis of immunoglobulins., PMID:39703160

Distinguishing Daratumumab from Endogenous Monoclonal Proteins in Serum from Multiple Myeloma Patients Using an Automated Mass Spectrometry System., PMID:39699179

The significance of free light-chain ratio in light-chain monoclonal gammopathy of undetermined significance: a flow cytometry sub-study of the iStopMM screening study., PMID:39695077

Light-Chain Myeloma Presented as Osseus Tumors: A Case Report., PMID:39688111

Document Download

Anti-Human Kappa Light Chain Antibody (R3F49).pdf