Catalog No.
RHD11302
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:250
Target
VAV1, VAV, Proto-oncogene vav
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P15498
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3E03
Biological and Clinical Relevance of Genetic Alterations in Peripheral T-cell Lymphomas., PMID:40416001
CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation., PMID:39990418
[ARL67156, a small-molecule CD39 inhibitor, enhances natural killer cell cytotoxicity against gastric cancer cells in vitro and in nude mice]., PMID:38189385
Vav proteins do not influence dengue virus replication but are associated with induction of phospho-ERK, IL-6, and viperin mRNA following DENV infection in vitro., PMID:38054722
Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell-mediated antitumor immunity., PMID:36377656
[Enhanced Natural Killers with CISH and B2M Gene Knockouts Reveal Increased Cytotoxicity in Glioblastoma Primary Cultures]., PMID:36165021
Lirilumab and Avelumab Enhance Anti-HPV+ Cervical Cancer Activity of Natural Killer Cells via Vav1-Dependent NF-κB Disinhibition., PMID:35174079
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling., PMID:34526379
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation., PMID:34471108
Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation., PMID:34294876
KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target., PMID:34244312
Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias., PMID:33753942
Vav family proteins constitute disparate branching points for distinct BCR signaling pathways., PMID:32671844
Adhesion to fibronectin via α5β1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis., PMID:32294178
NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity., PMID:31235500
CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis., PMID:30981760
CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes., PMID:30674283
Stage-specific requirement of kinase PDK1 for NK cells development and activation., PMID:30622306
Therapeutic Vaccine Against S100A9 (S100 Calcium-Binding Protein A9) Inhibits Thrombosis Without Increasing the Risk of Bleeding in Ischemic Stroke in Mice., PMID:30571223
A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire., PMID:30410484
Comparative analysis of histologically classified oligodendrogliomas reveals characteristic molecular differences between subgroups., PMID:29631562
The gp130 Cytokine Interleukin-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients., PMID:29235178
A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients., PMID:29194580
Mercury alters endogenous phosphorylation profiles of SYK in murine B cells., PMID:28716125
VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis., PMID:28053322
Indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway., PMID:27930920
Genes associated with common variable immunodeficiency: one diagnosis to rule them all?, PMID:27250108
Anti-CD20 Therapy Acts via FcγRIIIA to Diminish Responsiveness of Human Natural Killer Cells., PMID:26229120
Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms., PMID:25993291
Role of cortactin homolog HS1 in transendothelial migration of natural killer cells., PMID:25723543
Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism., PMID:25411767
T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice., PMID:25209945
Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis., PMID:25061875
Themis2 is not required for B cell development, activation, and antibody responses., PMID:24907343
p95-HER2 and trastuzumab resistance in metastatic breast cancer; is immunohistochemistry appropriate?, PMID:24659671
Clinical significance of p95HER2 overexpression, PTEN loss and PI3K expression in p185HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies., PMID:24595002
Lipid Raft is required for PSGL-1 ligation induced HL-60 cell adhesion on ICAM-1., PMID:24312591
The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis., PMID:24045941
Generation of mice with conditional ablation of the Cd40lg gene: new insights on the role of CD40L., PMID:24030045
Genetic control of HgCl2-induced IgE and autoimmunity by a 117-kb interval on rat chromosome 9 through CD4 CD45RChigh T cells., PMID:23615071
Vav1 haploinsufficiency in a common variable immunodeficiency patient with defective T-cell function., PMID:23058036
Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells., PMID:22786724
The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells., PMID:22289918
Enhancement of B-cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism., PMID:21794028
Mapping protein interactions by combining antibody affinity maturation and mass spectrometry., PMID:21704603
Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state., PMID:21427288
The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells., PMID:21151158
Transcriptome analysis and cytokine profiling of naive T cells stimulated by a tumor vaccine via CD3 and CD25., PMID:21042712
The lipid-modulating effects of a CD4-specific recombinant antibody correlate with ZAP-70 segregation outside membrane rafts., PMID:20659502
Lineage tracing and resulting phenotype of haemopoietic-derived cells in the pancreas during beta cell regeneration., PMID:20585934
For research use only. Not for human or drug use.
