Catalog No.
RHD03802
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
Cytolysin, Perforin-1, Lymphocyte pore-forming protein, PFP, PRF1, P1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P14222
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3D57
Baicalein tethers CD274/PD-L1 for autophagic degradation to boost antitumor immunity., PMID:39710370
DSP-0509, a TLR7 agonist, exerted synergistic anti-tumor immunity combined with various immune therapies through modulating diverse immune cells in cancer microenvironment., PMID:39346737
Genome-wide characterization of extrachromosomal circular DNA in SLE and functional analysis reveal their association with apoptosis., PMID:39173965
Identification of different functions of CD8+ T cell subpopulations by a novel monoclonal antibody., PMID:38922845
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis., PMID:38306418
Regulation and distribution of European sea bass perforins point to their role in the adaptive cytotoxic response against NNV., PMID:38000653
Exploring urinary extracellular vesicles for organ transplant monitoring: A comprehensive study for detection of allograft dysfunction using immune-specific markers., PMID:37633321
Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19., PMID:36881624
Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791
Role of Genetic Polymorphism Present in Macrophage Activation Syndrome Pathway in Post Mortem Biopsies of Patients with COVID-19., PMID:36016321
Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells., PMID:35658035
PTEN Loss and BRCA1 Promoter Hypermethylation Negatively Predict for Immunogenicity in BRCA-Deficient Ovarian Cancer., PMID:35201851
Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies., PMID:35013338
B7-H4 is increased in lung adenocarcinoma harboring EGFR-activating mutations and contributes to immunosuppression., PMID:34839353
A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients., PMID:34322127
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer., PMID:33958794
Immune cytopenias as a continuum in inborn errors of immunity: An in-depth clinical and immunological exploration., PMID:33838017
Identification of CD56dim subpopulation marked with high expression of GZMB/PRF1/PI-9 in CD56+ interferon-α-induced dendritic cells., PMID:33662167
Genetic biomarkers for intravenous immunoglobulin response in chronic inflammatory demyelinating polyradiculoneuropathy., PMID:33460483
Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders., PMID:33384688
Integrin and transcriptomic profiles identify a distinctive synovial CD8+ T cell subpopulation in spondyloarthritis., PMID:31471299
Genetic Deficiency of Interferon-γ Reveals Interferon-γ-Independent Manifestations of Murine Hemophagocytic Lymphohistiocytosis., PMID:31400073
Role of Regulatory B Cells in the Progression of Cervical Cancer., PMID:31316301
Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis., PMID:31015190
Haemophagocytic lymphohistiocytosis complicating pembrolizumab treatment for metastatic breast cancer in a patient with the PRF1A91V gene polymorphism., PMID:30287596
Immune Landscape of Colorectal Cancer Tumor Microenvironment from Different Primary Tumor Location., PMID:30042763
Suppression of autophagy and HCK signaling promotes PTGS2high FCGR3- NK cell differentiation triggered by ectopic endometrial stromal cells., PMID:29962266
Inhibiting HLA-G restores IFN-γ and TNF-α producing T cell in pleural Tuberculosis., PMID:29559123
Zika (PRVABC59) Infection Is Associated with T cell Infiltration and Neurodegeneration in CNS of Immunocompetent Neonatal C57Bl/6 Mice., PMID:27855206
Neonatal Haemophagocytic Lymphohistiocytosis Associated with Maternal Adult-Onset Still's Disease., PMID:27304999
Trypanosoma brucei Co-opts NK Cells to Kill Splenic B2 B Cells., PMID:27403737
A unique CD8(+) T lymphocyte signature in pediatric type 1 diabetes., PMID:27318739
ST2 contributes to T-cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice., PMID:26518437
Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance., PMID:26286066
Late-onset severe chronic active EBV in a patient for five years with mutations in STXBP2 (MUNC18-2) and PRF1 (perforin 1)., PMID:25947952
Spontaneous resolution of acute rejection and tolerance induction with IL-2 fusion protein in vascularized composite allotransplantation., PMID:25676865
Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity., PMID:25667415
A method for detecting intracellular perforin in mouse lymphocytes., PMID:25348626
IFNγ⁻TNFα⁻IL2⁻MIP1α⁻CD107a⁺PRF1⁺ CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans., PMID:25238774
Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes., PMID:25146929
Hematopoietic stem cell transplantation of an adolescent with neurological manifestations of homozygous missense PRF1 mutation., PMID:25110876
A possible familial lymphoproliferative disorder in two male siblings of children with recurrent wheezing and lung infections since infancy., PMID:24934116
Cytomegalovirus-responsive γδ T cells: novel effector cells in antibody-mediated kidney allograft microcirculation lesions., PMID:24744438
An A91V SNP in the perforin gene is frequently found in NK/T-cell lymphomas., PMID:24632576
Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients., PMID:24396833
Clinical and serological findings associated with the expression of ITGAL, PRF1, and CD70 in systemic lupus erythematosus., PMID:24238281
Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations., PMID:24051121
Intrinsic molecular factors cause aberrant expansion of the splenic marginal zone B cell population in nonobese diabetic mice., PMID:23740954
Natural killer cell dynamic profile is associated with treatment outcome in patients with chronic HCV infection., PMID:23499727
For research use only. Not for human or drug use.
