Catalog No.
RHC95905
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, WB: 1:500-1:1000
Target
Lupus Ku autoantigen protein p70, 5'-dRP lyase Ku70, Thyroid-lupus autoantigen, XRCC6, CTC box-binding factor 75 kDa subunit, X-ray repair complementing defective repair in Chinese hamster cells 6, G22P1, X-ray repair cross-complementing protein 6, ATP-dependent DNA helicase 2 subunit 1, DNA repair protein XRCC6, TLAA, ATP-dependent DNA helicase II 70 kDa subunit, CTCBF, 70 kDa subunit of Ku antigen, Ku70, 5'-deoxyribose-5-phosphate lyase Ku70, CTC75
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P12956
Applications
IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3D08
The DNA repair factor ku80 binds and activates the adhesion receptor ELTD1/ADGRL4., PMID:40245572
Anti-Ku + myositis: an acquired inflammatory protein-aggregate myopathy., PMID:39012547
Further expanding the phenotype of anti-Ku antibody associated disease in children and adolescents., PMID:38805897
Nuclear expression of Ku70/80 is associated with CHEK2 germline mutations in breast cancer., PMID:37728466
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology., PMID:34635772
Dermatan Sulfate Is a Potential Regulator of IgH via Interactions With Pre-BCR, GTF2I, and BiP ER Complex in Pre-B Lymphoblasts., PMID:34113352
Assessment of DNA damage by 53PB1 and pKu70 detection in peripheral blood lymphocytes by immunofluorescence and high-resolution transmission electron microscopy., PMID:32006067
Characterisation of a human antibody that potentially links cytomegalovirus infection with systemic lupus erythematosus., PMID:31292492
Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination., PMID:28176781
Regulation of the Ku70 and apoptosis-related proteins in experimental diabetic nephropathy., PMID:27621182
[Autoimmune diseases with the presence of anti-ku antibodies - analysis of three cases]., PMID:27162291
Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway., PMID:27121057
A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines., PMID:26337656
The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair., PMID:26293673
Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis., PMID:26246178
Childhood-Onset Anti-Ku Antibody-Positive Generalized Morphea with Polymyositis: A Japanese Case Study., PMID:26205636
Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells., PMID:26073085
Nuclear localization of mouse Ku70 in interphase cells and focus formation of mouse Ku70 at DNA damage sites immediately after irradiation., PMID:25947323
Involvement of DNA-PKcs in the type I IFN response to CpG-ODNs in conventional dendritic cells in TLR9-dependent or -independent manners., PMID:25812014
Association Between Functional Polymorphisms of DNA Double-Strand Breaks in Repair Genes XRCC5, XRCC6 and XRCC7 with the Risk of Systemic Lupus Erythematosus in South East Iran., PMID:25756210
[Serum anti-Ku86: a potential biomarker for early detection of hepatocellular carcinoma]., PMID:24796461
7B7: a novel antibody directed against the Ku70/Ku80 heterodimer blocks invasion in pancreatic and lung cancer cells., PMID:24744142
Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity., PMID:24466340
Characterization of estrogen response element binding proteins as biomarkers of breast cancer behavior., PMID:23868020
Case of diffuse cutaneous systemic sclerosis with anti-Ku and anti-centromere antibodies., PMID:23663134
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production., PMID:23441136
High LET radiation amplifies centrosome overduplication through a pathway of γ-tubulin monoubiquitination., PMID:23433796
Phosphorothioate-modified CpG oligodeoxynucleotides mimic autoantigens and reveal a potential role for Toll-like receptor 9 in receptor revision., PMID:23289794
Nampt is involved in DNA double-strand break repair., PMID:22704488
The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination., PMID:22570620
Serum anti-Ku86 is a potential biomarker for early detection of hepatitis C virus-related hepatocellular carcinoma., PMID:22554520
DNA ends alter the molecular composition and localization of Ku multicomponent complexes., PMID:22535209
Camptocormia as a clinical manifestation of polymyositis/systemic sclerosis overlap myositis associated with anti-Ku., PMID:22453528
Inflammatory myopathies with anti-Ku antibodies: a prognosis dependent on associated lung disease., PMID:22391471
[Influence of epidermal growth factor receptor monoclony antibody MAb225 on DNA repair of tongue carcinoma cell after radiation]., PMID:22332566
International cohort study of 73 anti-Ku-positive patients: association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysis., PMID:22226402
Facial nerve palsy and anti-Ku autoantibodies., PMID:21769532
Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair., PMID:21256093
Absence of hemolytic disease of fetus and newborn despite maternal high-titer IgG anti-Ku., PMID:21214298
The effect of DNA-dependent protein kinase on adeno-associated virus replication., PMID:21188139
Ku86 is important for TrkA overexpression-induced breast cancer cell invasion., PMID:21137076
Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair., PMID:21135220
Enhancement of Zta-activated lytic transcription of Epstein-Barr virus by Ku80., PMID:21123545
[Anti-Ku antibodies]., PMID:20942132
Anti-Ku antibodies: Clinical, genetic and diagnostic insights., PMID:20621654
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway., PMID:20538911
Malignant T cells in cutaneous T-cell lymphoma lesions contain decreased levels of the antiapoptotic protein Ku70., PMID:20408834
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4., PMID:20142431
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70., PMID:20133803
Exogenously expressed human Ku70 stabilizes Ku80 in Xenopus oocytes and induces heterologous DNA-PK catalytic activity., PMID:20047046
For research use only. Not for human or drug use.
