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Anti-XRCC6/Ku70 Antibody (R3D08)

Catalog #:   RHC95905 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2b
Applications: IF, WB
Accession: P12956
Overview

Catalog No.

RHC95905

Species reactivity

Human

Host species

Mouse

Isotype

IgG2b

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, WB: 1:500-1:1000

Target

Lupus Ku autoantigen protein p70, 5'-dRP lyase Ku70, Thyroid-lupus autoantigen, XRCC6, CTC box-binding factor 75 kDa subunit, X-ray repair complementing defective repair in Chinese hamster cells 6, G22P1, X-ray repair cross-complementing protein 6, ATP-dependent DNA helicase 2 subunit 1, DNA repair protein XRCC6, TLAA, ATP-dependent DNA helicase II 70 kDa subunit, CTCBF, 70 kDa subunit of Ku antigen, Ku70, 5'-deoxyribose-5-phosphate lyase Ku70, CTC75

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P12956

Applications

IF, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3D08

Data Image
  • Immunofluorescence
    Immunocytochemistry analysis of Ku70 in HeLa using Ku70 antibody.
  • Western blot
    Western blot analysis of Ku70 in Hela, A549, MCF-7, Jurkat and Raji lysates using Ku70 antibody.
References

The DNA repair factor ku80 binds and activates the adhesion receptor ELTD1/ADGRL4., PMID:40245572

Anti-Ku + myositis: an acquired inflammatory protein-aggregate myopathy., PMID:39012547

Further expanding the phenotype of anti-Ku antibody associated disease in children and adolescents., PMID:38805897

Nuclear expression of Ku70/80 is associated with CHEK2 germline mutations in breast cancer., PMID:37728466

HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology., PMID:34635772

Dermatan Sulfate Is a Potential Regulator of IgH via Interactions With Pre-BCR, GTF2I, and BiP ER Complex in Pre-B Lymphoblasts., PMID:34113352

Assessment of DNA damage by 53PB1 and pKu70 detection in peripheral blood lymphocytes by immunofluorescence and high-resolution transmission electron microscopy., PMID:32006067

Characterisation of a human antibody that potentially links cytomegalovirus infection with systemic lupus erythematosus., PMID:31292492

Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination., PMID:28176781

Regulation of the Ku70 and apoptosis-related proteins in experimental diabetic nephropathy., PMID:27621182

[Autoimmune diseases with the presence of anti-ku antibodies - analysis of three cases]., PMID:27162291

Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway., PMID:27121057

A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines., PMID:26337656

The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair., PMID:26293673

Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis., PMID:26246178

Childhood-Onset Anti-Ku Antibody-Positive Generalized Morphea with Polymyositis: A Japanese Case Study., PMID:26205636

Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells., PMID:26073085

Nuclear localization of mouse Ku70 in interphase cells and focus formation of mouse Ku70 at DNA damage sites immediately after irradiation., PMID:25947323

Involvement of DNA-PKcs in the type I IFN response to CpG-ODNs in conventional dendritic cells in TLR9-dependent or -independent manners., PMID:25812014

Association Between Functional Polymorphisms of DNA Double-Strand Breaks in Repair Genes XRCC5, XRCC6 and XRCC7 with the Risk of Systemic Lupus Erythematosus in South East Iran., PMID:25756210

[Serum anti-Ku86: a potential biomarker for early detection of hepatocellular carcinoma]., PMID:24796461

7B7: a novel antibody directed against the Ku70/Ku80 heterodimer blocks invasion in pancreatic and lung cancer cells., PMID:24744142

Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity., PMID:24466340

Characterization of estrogen response element binding proteins as biomarkers of breast cancer behavior., PMID:23868020

Case of diffuse cutaneous systemic sclerosis with anti-Ku and anti-centromere antibodies., PMID:23663134

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production., PMID:23441136

High LET radiation amplifies centrosome overduplication through a pathway of γ-tubulin monoubiquitination., PMID:23433796

Phosphorothioate-modified CpG oligodeoxynucleotides mimic autoantigens and reveal a potential role for Toll-like receptor 9 in receptor revision., PMID:23289794

Nampt is involved in DNA double-strand break repair., PMID:22704488

The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination., PMID:22570620

Serum anti-Ku86 is a potential biomarker for early detection of hepatitis C virus-related hepatocellular carcinoma., PMID:22554520

DNA ends alter the molecular composition and localization of Ku multicomponent complexes., PMID:22535209

Camptocormia as a clinical manifestation of polymyositis/systemic sclerosis overlap myositis associated with anti-Ku., PMID:22453528

Inflammatory myopathies with anti-Ku antibodies: a prognosis dependent on associated lung disease., PMID:22391471

[Influence of epidermal growth factor receptor monoclony antibody MAb225 on DNA repair of tongue carcinoma cell after radiation]., PMID:22332566

International cohort study of 73 anti-Ku-positive patients: association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysis., PMID:22226402

Facial nerve palsy and anti-Ku autoantibodies., PMID:21769532

Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair., PMID:21256093

Absence of hemolytic disease of fetus and newborn despite maternal high-titer IgG anti-Ku., PMID:21214298

The effect of DNA-dependent protein kinase on adeno-associated virus replication., PMID:21188139

Ku86 is important for TrkA overexpression-induced breast cancer cell invasion., PMID:21137076

Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair., PMID:21135220

Enhancement of Zta-activated lytic transcription of Epstein-Barr virus by Ku80., PMID:21123545

[Anti-Ku antibodies]., PMID:20942132

Anti-Ku antibodies: Clinical, genetic and diagnostic insights., PMID:20621654

Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway., PMID:20538911

Malignant T cells in cutaneous T-cell lymphoma lesions contain decreased levels of the antiapoptotic protein Ku70., PMID:20408834

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4., PMID:20142431

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70., PMID:20133803

Exogenously expressed human Ku70 stabilizes Ku80 in Xenopus oocytes and induces heterologous DNA-PK catalytic activity., PMID:20047046

Datasheet
$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-XRCC6/Ku70 Antibody (R3D08) [RHC95905]
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