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Anti-FCER1A Antibody (R3C88)

Catalog #:   RHC93602 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: ELISA, FCM, WB
Accession: P12319
Overview

Catalog No.

RHC93602

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000

Target

FcERI, IgE Fc receptor subunit alpha, FCER1A, Fc-epsilon RI-alpha, FCE1A, High affinity immunoglobulin epsilon receptor subunit alpha

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P12319

Applications

ELISA, FCM, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3C88

Data Image
  • Flow Cytometry
    Flow cytometric analysis of HEK293 cells using FCER1A mouse mAb (green) and negative control (red).
  • Western blot
    Western blot analysis using FCER1A mouse mAb against SW620 (1), A549 (2), and A431 (3) cell lysate.
References

Drug survival of omalizumab in atopic asthma: Impact of clinical and genetic variables., PMID:40189906

Elevated MS4A2 and IgE interaction in nasal polyps contributing to poor postoperative prognosis in patients with eosinophilic chronic rhinosinusitis., PMID:39828458

SingleNucleotide Polymorphisms as Biomarkers of Mepolizumab and Benralizumab Treatment Response in Severe Eosinophilic Asthma., PMID:39125709

Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology., PMID:38201301

A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcεRIα., PMID:37154775

Influence of Genetics on the Response to Omalizumab in Patients with Severe Uncontrolled Asthma with an Allergic Phenotype., PMID:37108192

Topical emollient prevents the development of atopic dermatitis and atopic march in mice., PMID:37029953

Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcεRI in mast cells., PMID:36368013

Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease., PMID:36153599

FcεRI deficiency alleviates silica-induced pulmonary inflammation and fibrosis., PMID:36087468

Inhibition of immunoglobulin E attenuates pulmonary hypertension., PMID:39196237

A novel detection method for cross-linking of IgE-receptors by autoantibodies in chronic spontaneous urticaria., PMID:34465532

Involvement of Activation of Mast Cells via IgE Signaling and Epithelial Cell-Derived Cytokines in the Pathogenesis of Pollen Food Allergy Syndrome in a Murine Model., PMID:34127520

Cataloguing experimentally confirmed 80.7 kb-long ACKR1 haplotypes from the 1000 Genomes Project database., PMID:34039276

Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma., PMID:33784348

The relationship between released soluble FceRI-alpha and its cell surface density on human basophils., PMID:33481953

Vitamin D3-Induced Promotor Dissociation of PU.1 and YY1 Results in FcεRI Reduction on Dendritic Cells in Atopic Dermatitis., PMID:33443066

Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis., PMID:32883546

AGK2 ameliorates mast cell-mediated allergic airway inflammation and fibrosis by inhibiting FcεRI/TGF-β signaling pathway., PMID:32565308

Imaging FCS delineates subtle heterogeneity in plasma membranes of resting mast cells., PMID:31895009

Identification of increased expression of activating Fc receptors and novel findings regarding distinct IgE and IgM receptors in Kawasaki disease., PMID:31816620

Characterization of human FcεRIα chain expression and gene copy number in humanized rat basophilic leukaemia (RBL) reporter cell lines., PMID:31430311

Selection and characterization of FcεRI phospho-ITAM specific antibodies., PMID:31311408

Dendritic Cell Activating Receptor 1 (DCAR1) Associates With FcεRIγ and Is Expressed by Myeloid Cell Subsets in the Rat., PMID:31134097

Role of the IgE variable heavy chain in FcεRIα and superantigen binding in allergy and immunotherapy., PMID:30995457

The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses., PMID:30735559

Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases., PMID:30658649

CD45 exclusion- and cross-linking-based receptor signaling together broaden FcεRI reactivity., PMID:30563863

The Fab fragment of anti-IgE Cε2 domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells., PMID:30250145

Experimental Models for Studying Food Allergy., PMID:30182049

Spirulina maxima peptides suppress mast cell degranulation via inactivating Akt and MAPKs phosphorylation in RBL-2H3 cells., PMID:30016657

Diagnosis, pathogenesis, and treatment of chronic spontaneous urticaria., PMID:29669665

An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE., PMID:29654623

FcɛR1α gene polymorphism shows association with high IgE and anti-FcɛR1α in Chronic Rhinosinusitis with Nasal Polyposis., PMID:29243845

Allergic Airway Disease: More than Meets the IgE?, PMID:29192831

Differential Ca2+ mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling., PMID:29029788

Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics., PMID:28855374

Antiallergic effect of fisetin on IgE-mediated mast cell activation in vitro and on passive cutaneous anaphylaxis (PCA)., PMID:28797929

Spontaneous food allergy in Was-/- mice occurs independent of FcεRI-mediated mast cell activation., PMID:28600891

Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children., PMID:28350867

Inhibitory Effects of Viscum coloratum Extract on IgE/Antigen-Activated Mast Cells and Mast Cell-Derived Inflammatory Mediator-Activated Chondrocytes., PMID:28036032

2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway., PMID:27890918

Antibody to FcεRIα Suppresses Immunoglobulin E Binding to High-Affinity Receptor I in Allergic Inflammation., PMID:27593869

Specific allergen immunotherapy attenuates allergic airway inflammation in a rat model of Alstonia scholaris pollen induced airway allergy., PMID:26667977

IgE antibodies, FcεRIα, and IgE-mediated local anaphylaxis can limit snake venom toxicity., PMID:26410782

Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice., PMID:26295369

Gender-related effects of sex steroids on histamine release and FcεRI expression in rat peritoneal mast cells., PMID:25973435

Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients., PMID:25412950

The role of peptides derived from Spirulina maxima in downregulation of FcεRI-mediated allergic responses., PMID:25164681

Development of β-lactoglobulin-specific chimeric human IgEκ monoclonal antibodies for in vitro safety assessment of whey hydrolysates., PMID:25153680

Datasheet

Document Download

Anti-FCER1A Antibody (R3C88).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-FCER1A Antibody (R3C88) [RHC93602]
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