Catalog No.
RHC93602
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000
Target
FcERI, IgE Fc receptor subunit alpha, FCER1A, Fc-epsilon RI-alpha, FCE1A, High affinity immunoglobulin epsilon receptor subunit alpha
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P12319
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3C88
Drug survival of omalizumab in atopic asthma: Impact of clinical and genetic variables., PMID:40189906
Elevated MS4A2 and IgE interaction in nasal polyps contributing to poor postoperative prognosis in patients with eosinophilic chronic rhinosinusitis., PMID:39828458
SingleNucleotide Polymorphisms as Biomarkers of Mepolizumab and Benralizumab Treatment Response in Severe Eosinophilic Asthma., PMID:39125709
Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology., PMID:38201301
A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcεRIα., PMID:37154775
Influence of Genetics on the Response to Omalizumab in Patients with Severe Uncontrolled Asthma with an Allergic Phenotype., PMID:37108192
Topical emollient prevents the development of atopic dermatitis and atopic march in mice., PMID:37029953
Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcεRI in mast cells., PMID:36368013
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease., PMID:36153599
FcεRI deficiency alleviates silica-induced pulmonary inflammation and fibrosis., PMID:36087468
Inhibition of immunoglobulin E attenuates pulmonary hypertension., PMID:39196237
A novel detection method for cross-linking of IgE-receptors by autoantibodies in chronic spontaneous urticaria., PMID:34465532
Involvement of Activation of Mast Cells via IgE Signaling and Epithelial Cell-Derived Cytokines in the Pathogenesis of Pollen Food Allergy Syndrome in a Murine Model., PMID:34127520
Cataloguing experimentally confirmed 80.7 kb-long ACKR1 haplotypes from the 1000 Genomes Project database., PMID:34039276
Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma., PMID:33784348
The relationship between released soluble FceRI-alpha and its cell surface density on human basophils., PMID:33481953
Vitamin D3-Induced Promotor Dissociation of PU.1 and YY1 Results in FcεRI Reduction on Dendritic Cells in Atopic Dermatitis., PMID:33443066
Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis., PMID:32883546
AGK2 ameliorates mast cell-mediated allergic airway inflammation and fibrosis by inhibiting FcεRI/TGF-β signaling pathway., PMID:32565308
Imaging FCS delineates subtle heterogeneity in plasma membranes of resting mast cells., PMID:31895009
Identification of increased expression of activating Fc receptors and novel findings regarding distinct IgE and IgM receptors in Kawasaki disease., PMID:31816620
Characterization of human FcεRIα chain expression and gene copy number in humanized rat basophilic leukaemia (RBL) reporter cell lines., PMID:31430311
Selection and characterization of FcεRI phospho-ITAM specific antibodies., PMID:31311408
Dendritic Cell Activating Receptor 1 (DCAR1) Associates With FcεRIγ and Is Expressed by Myeloid Cell Subsets in the Rat., PMID:31134097
Role of the IgE variable heavy chain in FcεRIα and superantigen binding in allergy and immunotherapy., PMID:30995457
The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses., PMID:30735559
Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases., PMID:30658649
CD45 exclusion- and cross-linking-based receptor signaling together broaden FcεRI reactivity., PMID:30563863
The Fab fragment of anti-IgE Cε2 domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells., PMID:30250145
Experimental Models for Studying Food Allergy., PMID:30182049
Spirulina maxima peptides suppress mast cell degranulation via inactivating Akt and MAPKs phosphorylation in RBL-2H3 cells., PMID:30016657
Diagnosis, pathogenesis, and treatment of chronic spontaneous urticaria., PMID:29669665
An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE., PMID:29654623
FcɛR1α gene polymorphism shows association with high IgE and anti-FcɛR1α in Chronic Rhinosinusitis with Nasal Polyposis., PMID:29243845
Allergic Airway Disease: More than Meets the IgE?, PMID:29192831
Differential Ca2+ mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling., PMID:29029788
Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics., PMID:28855374
Antiallergic effect of fisetin on IgE-mediated mast cell activation in vitro and on passive cutaneous anaphylaxis (PCA)., PMID:28797929
Spontaneous food allergy in Was-/- mice occurs independent of FcεRI-mediated mast cell activation., PMID:28600891
Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children., PMID:28350867
Inhibitory Effects of Viscum coloratum Extract on IgE/Antigen-Activated Mast Cells and Mast Cell-Derived Inflammatory Mediator-Activated Chondrocytes., PMID:28036032
2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway., PMID:27890918
Antibody to FcεRIα Suppresses Immunoglobulin E Binding to High-Affinity Receptor I in Allergic Inflammation., PMID:27593869
Specific allergen immunotherapy attenuates allergic airway inflammation in a rat model of Alstonia scholaris pollen induced airway allergy., PMID:26667977
IgE antibodies, FcεRIα, and IgE-mediated local anaphylaxis can limit snake venom toxicity., PMID:26410782
Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice., PMID:26295369
Gender-related effects of sex steroids on histamine release and FcεRI expression in rat peritoneal mast cells., PMID:25973435
Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients., PMID:25412950
The role of peptides derived from Spirulina maxima in downregulation of FcεRI-mediated allergic responses., PMID:25164681
Development of β-lactoglobulin-specific chimeric human IgEκ monoclonal antibodies for in vitro safety assessment of whey hydrolysates., PMID:25153680
For research use only. Not for human or drug use.
