Catalog No.
RHC77901
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:500
Target
GLI family zinc finger protein 2, THP, Tax helper protein, GLI2, Zinc finger protein GLI2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P10070
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3C01
Epigenetic Effects of Resveratrol on Oncogenic Signaling in Breast Cancer., PMID:38474826
LMCD1 antisense RNA 1 is a newly identified long noncoding RNA., PMID:34232945
Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation., PMID:34062094
New insights into the GDF9-Hedgehog-GLI signaling pathway in human ovaries: from fetus to postmenopause., PMID:33772413
The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis., PMID:30982371
Combination of phospholipase Cε knockdown with GANT61 sensitizes castration‑resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway., PMID:30864728
Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer., PMID:30647844
Regulation of Gli2 stability by deubiquitinase OTUB2., PMID:30241937
Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation., PMID:29582169
Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse., PMID:29487109
Analysis of hedgehog signaling in periocular sebaceous carcinoma., PMID:29423837
Endometrial stem cell-derived granulocyte-colony stimulating factor attenuates endometrial fibrosis via sonic hedgehog transcriptional activator Gli2., PMID:29329377
Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling., PMID:29221447
The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI., PMID:28877478
PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant., PMID:28673820
Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma., PMID:28551328
Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells., PMID:28144905
Primary cilia on porcine testicular somatic cells and their role in hedgehog signaling and tubular morphogenesis in vitro., PMID:27841005
Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway., PMID:26718029
Modulation of the IL-6 Receptor α Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells., PMID:26238488
Measuring Expression Levels of Endogenous Gli Genes by Immunoblotting and Real-Time PCR., PMID:26179041
Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retina., PMID:26116667
A de novo 10.79 Mb interstitial deletion at 2q13q14.2 involving PAX8 causing hypothyroidism and mullerian agenesis: a novel case report and literature review., PMID:25484916
GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis., PMID:25432075
Sonic hedgehog signalling proteins are frequently expressed in retinoblastoma and are associated with aggressive clinicopathological features., PMID:25296932
Targeting the hedgehog-glioma-associated oncogene homolog pathway inhibits bleomycin-induced lung fibrosis in mice., PMID:24450438
Sonic hedgehog pathway dysregulation in skin basal-cell carcinoma of a Polish population., PMID:24203628
Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells., PMID:24086482
Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma., PMID:23835807
The oncogenic GLI transcription factors facilitate keratinocyte survival and transformation upon exposure to genotoxic agents., PMID:23792444
Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy., PMID:23762415
NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200., PMID:23482671
Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling., PMID:23166838
Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion., PMID:23028941
Morphoproteomics provides support for TGF-β pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis., PMID:22949932
Sonic hedgehog released from scratch-injured astrocytes is a key signal necessary but not sufficient for the astrocyte de-differentiation., PMID:22771389
Neuron precursor features of spindle cell oncocytoma of adenohypophysis., PMID:22585606
Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function., PMID:21664576
GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment., PMID:21454528
Sonic hedgehog stimulates proliferation of human periodontal ligament stem cells., PMID:21441223
Bone structural components regulating sites of tumor metastasis., PMID:21424744
Comprehensive keratin profiling reveals different histopathogenesis of keratocystic odontogenic tumor and orthokeratinized odontogenic cyst., PMID:20801488
Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor., PMID:20371205
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation., PMID:20154143
Canonical Wnt signaling regulates Foxc1/2 expression in P19 cells., PMID:19782461
Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein., PMID:19759178
Expression of hedgehog signaling molecules in Merkel cell carcinoma., PMID:19644931
Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium., PMID:19432668
Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells., PMID:19245435
Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas., PMID:19200615
For research use only. Not for human or drug use.
