Catalog No.
RHC30602
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000
Target
Oncogene GLI, GLI, Glioma-associated oncogene, GLI1, Zinc finger protein GLI1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P08151
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3A58
Comparison of the bone remodeling in the midpalatal suture during maxillary expansion between young and middle-aged mice., PMID:40324615
PlexinD1 is a driver and a therapeutic target in advanced prostate cancer., PMID:39748059
Tumor-derived GLI1 promotes remodeling of the immune tumor microenvironment in melanoma., PMID:39090759
The Combined Immunohistochemical Expression of GLI1 and BCOR in Synovial Sarcomas for the Identification of Three Risk Groups and Their Prognostic Outcomes: A Study of 52 Patients., PMID:39062853
Gli1-mediated tumor cell-derived bFGF promotes tumor angiogenesis and pericyte coverage in non-small cell lung cancer., PMID:38493151
Gene of the month: DDIT3., PMID:38053287
Integrated PK/PD Modeling Relates Smoothened Inhibitor Biomarkers to The Heterogeneous Intratumor Disposition of Cetuximab in Pancreatic Cancer Tumor Models., PMID:37844759
PIWI interacting RNA-13643 contributes to papillary thyroid cancer development through acting as a novel oncogene by facilitating PRMT1 mediated GLI1 methylation., PMID:37657666
EZH2 regulates pancreatic cancer cells through E2F1, GLI1, CDK3, and Mcm4., PMID:37198697
GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration., PMID:36734208
Optimized immunofluorescence staining protocol for identifying resident mesenchymal stem cells in bone using LacZ transgenic mice., PMID:36107746
Preliminary results on a proposed histopathological assessment of predictive factors for basal cell carcinoma recurrence after primary free margin excision., PMID:35677922
Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program., PMID:35576232
Aniridia-related keratopathy relevant cell signaling pathways in human fetal corneas., PMID:35551459
Two Cases of Temporomandibular Synovial Chondromatosis Associated with Gli1 Gene Mutation., PMID:35457572
C-X-C motif chemokine ligand 1 induced by Hedgehog signaling promotes mouse extrahepatic bile duct repair after acute injury., PMID:35388502
Exploration of autoantibody responses in canine diabetes using protein arrays., PMID:35169238
Construction of a target MSNs drugcarrier loaded with siRNAGLI1 and siRNASMO aim at hedgehog signal pathway and the pharmacodynamic study of drug-carriers in the treatment of leukemia stem cells., PMID:35113326
Targeting CD99 Compromises the Oncogenic Effects of the Chimera EWS-FLI1 by Inducing Reexpression of Zyxin and Inhibition of GLI1 Activity., PMID:34667115
Identification of GPC3 mutation and upregulation in a multidrug resistant osteosarcoma and its spheroids as therapeutic target., PMID:34611509
Regulating Fibrocartilage Stem Cells via TNF-α/Nf-κB in TMJ Osteoarthritis., PMID:34515572
New insights into the GDF9-Hedgehog-GLI signaling pathway in human ovaries: from fetus to postmenopause., PMID:33772413
Targeted Dual Small Interfering Ribonucleic Acid Delivery via Non-Viral Polymeric Vectors for Pulmonary Fibrosis Therapy., PMID:33604928
[Fibrosis-driving cells in patients with primary myelofibrosis and myelodysplastic syndromes with myelofibrosis]., PMID:33445847
Hedgehog pathway activation in oral squamous cell carcinoma: cancer-associated fibroblasts exhibit nuclear GLI-1 localization., PMID:33000351
Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis., PMID:32929154
The hedgehog pathway regulates cancer stem cells in serous adenocarcinoma of the ovary., PMID:32382997
Noncalcemic Vitamin D Hydroxyderivatives Inhibit Human Oral Squamous Cell Carcinoma and Down-regulate Hedgehog and WNT/β-Catenin Pathways., PMID:32366390
Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients., PMID:32194829
Coordinated hedgehog signaling induces new hair follicles in adult skin., PMID:32178760
Sonic hedgehog pathway activation is associated with cetuximab resistance and EPHB3 receptor induction in colorectal cancer., PMID:31149041
Taurine enhances mouse cochlear neural stem cell transplantation via the cochlear lateral wall for replacement of degenerated spiral ganglion neurons via sonic hedgehog signaling pathway., PMID:31016387
The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis., PMID:30982371
FOXS1 is regulated by GLI1 and miR-125a-5p and promotes cell proliferation and EMT in gastric cancer., PMID:30918291
Combination of phospholipase Cε knockdown with GANT61 sensitizes castration‑resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway., PMID:30864728
Application of Cell Lineage Tracing Combined with Immunofluorescence in the Study of Dentinogenesis., PMID:30838563
Altered Signaling Pathways in Aniridia-Related Keratopathy., PMID:30480741
Taurine enhances mouse cochlear neural stem cells proliferation and differentiation to sprial gangli through activating sonic hedgehog signaling pathway., PMID:30102120
Immunohistochemical visualization of the signature of activated Hedgehog signaling pathway in cutaneous epithelial tumors., PMID:30035333
[The role of Sonic Hedgehog signaling pathway in the development of oral squamous cell carcinoma]., PMID:29992931
Loss of sonic hedgehog gene leads to muscle development disorder and megaesophagus in mice., PMID:29768039
The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway., PMID:29722127
Analysis of hedgehog signaling in periocular sebaceous carcinoma., PMID:29423837
Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling., PMID:29221447
Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway., PMID:28951519
The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI., PMID:28877478
Complement component C3aR constitutes a novel regulator for chick eye morphogenesis., PMID:28576690
Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma., PMID:28551328
[Immunohistochemical criteria for differential diagnostics of squamous epithelium changes in pyogenic granuloma and squamous cell carcinoma of the oral mucosa]., PMID:28514345
Hedgehog signalling pathway orchestrates angiogenesis in triple-negative breast cancers., PMID:28441382
For research use only. Not for human or drug use.
