Catalog No.
RHC30201
Species reactivity
Human, Mouse, Rat, Monkey
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, WB: 1:500-1:1000
Target
Collagen alpha-2(I) chain, COL1A2, Alpha-2 type I collagen
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P08123
Applications
ELISA, FCM, IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3A55
The effect of tocilizumab treatment for skin fibrosis by inhibiting CD38+ macrophages in systemic sclerosis., PMID:39778381
Suppression of renal crystal formation, inflammation, and fibrosis by blocking oncostatin M receptor β signaling., PMID:39572752
Setrusumab for the treatment of osteogenesis imperfecta: 12-month results from the phase 2b asteroid study., PMID:39012717
Tumor-matched and unmatched cancer associated fibroblasts exhibit differential effect on proliferation and FMOD and MMP9 gene expression in head and neck squamous cell carcinoma cells when cocultured in spheroids., PMID:38822309
Galunisertib downregulates mutant type I collagen expression and promotes MSCs osteogenesis in pediatric osteogenesis imperfecta., PMID:38744219
Whole-Body Metabolism and the Musculoskeletal Impacts of Targeting Activin A and Myostatin in Severe Osteogenesis Imperfecta., PMID:37457877
Bone marrow-derived fibroblast migration via periostin causes irreversible arthrogenic contracture after joint immobilization., PMID:37000501
Identification of key genes in colorectal cancer diagnosis by co-expression analysis weighted gene co-expression network analysis., PMID:36931200
Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice., PMID:35966595
Circulating TGF-β Pathway in Osteogenesis Imperfecta Pediatric Patients Subjected to MSCs-Based Cell Therapy., PMID:35223854
ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis., PMID:34917911
Inhibition of TGF-β Increases Bone Volume and Strength in a Mouse Model of Osteogenesis Imperfecta., PMID:34532615
CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma., PMID:33428680
Impact of Genetic and Pharmacologic Inhibition of Myostatin in a Murine Model of Osteogenesis Imperfecta., PMID:33249643
Blockade of IL-33 signalling attenuates osteoarthritis., PMID:33133598
Osteogenesis imperfecta: an update on clinical features and therapies., PMID:32621590
The inhibition of bone morphogenetic protein 1 attenuates endometriosis lesions in vivo and in vitro., PMID:32524385
Activation of the MET receptor attenuates doxorubicin-induced cardiotoxicity in vivo and in vitro., PMID:32133617
Transplacental arsenic exposure produced 5-methylcytosine methylation changes and aberrant microRNA expressions in livers of male fetal mice., PMID:32068019
Fracture Healing in Collagen-Related Preclinical Models of Osteogenesis Imperfecta., PMID:32053224
Sclerostin-Antibody Treatment Decreases Fracture Rates in Axial Skeleton and Improves the Skeletal Phenotype in Growing oim/oim Mice., PMID:32025752
Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy and autoimmunity., PMID:31829272
Combination therapy in the Col1a2G610C mouse model of Osteogenesis Imperfecta reveals an additive effect of enhancing LRP5 signaling and inhibiting TGFβ signaling on trabecular bone but not on cortical bone., PMID:31648079
Individualized treatment with denosumab in children with osteogenesis imperfecta - follow up of a trial cohort., PMID:31533771
Osteogenesis Imperfecta: New Perspectives From Clinical and Translational Research., PMID:31485550
Identification of a novel BOC-PLAG1 fusion gene in a case of lipoblastoma., PMID:30857637
Current concepts in osteogenesis imperfecta: bone structure, biomechanics and medical management., PMID:30838070
Group 2 innate lymphoid cells (ILC2) are regulated by stem cell factor during chronic asthmatic disease., PMID:30617299
Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma., PMID:29885461
Correlation of Bone Mineral Density on Quality of Life in Patients with Osteogenesis Imperfecta during Treatment with Denosumab., PMID:29292876
Role of PDGF-BB in proliferation, differentiation and maintaining stem cell properties of PDL cells in vitro., PMID:29028628
Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta., PMID:28461254
Amelioration of non-alcoholic fatty liver disease with NPC1L1-targeted IgY or n-3 polyunsaturated fatty acids in mice., PMID:27923447
Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria., PMID:27187580
Compression therapy affects collagen type balance in hypertrophic scar., PMID:27020811
Mapping and Exploring the Collagen-I Proteostasis Network., PMID:26848503
Local fibroblast proliferation but not influx is responsible for synovial hyperplasia in a murine model of rheumatoid arthritis., PMID:26806309
Binding loci of RelA-containing nuclear factor-kappaB dimers in promoter regions of PHM1-31 myometrial smooth muscle cells., PMID:26405173
Selective delivery of IFN-γ to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis., PMID:25466892
Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta., PMID:24793237
Targeting the LRP5 pathway improves bone properties in a mouse model of osteogenesis imperfecta., PMID:24677211
Keap1 inhibition attenuates glomerulosclerosis., PMID:24523358
Attenuation of CCl4-induced hepatic fibrosis in mice by vaccinating against TGF-β1., PMID:24349218
B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis., PMID:24289101
Type V collagen induced tolerance suppresses collagen deposition, TGF-β and associated transcripts in pulmonary fibrosis., PMID:24204629
Cytokine-induced chromatin modifications of the type I collagen alpha 2 gene during intestinal endothelial-to-mesenchymal transition., PMID:23635716
Ghrelin attenuates collagen production in lesional fibroblasts from patients with systemic sclerosis., PMID:23571102
Activation of COL1A2 promoter in human fibroblasts by Escherichia coli., PMID:22534007
Feedback regulation of the α2(1) collagen gene via the Mek-Erk signaling pathway., PMID:22131293
For research use only. Not for human or drug use.
