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Anti-FH Antibody (R3A42)

Catalog #:   RHC29105 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: IF, IHC, WB
Accession: P07954
Overview

Catalog No.

RHC29105

Species reactivity

Human, Mouse, Rat

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, IHC: 1:50-1:100, WB: 1:500-1:1000

Target

Fumarase, HsFH, Fumarate hydratase, mitochondrial, FH

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P07954

Applications

IF, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3A42

Data Image
  • Immunofluorescence
    Immunocytochemistry analysis of FH/Fumarase (green) in Hela using FH/Fumarase antibody ,and DAPI(blue)
  • Immunohistochemical
    Immunohistochemistry analysis of paraffin-embedded Human tonsil tissue using FH/Fumarase antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
  • Western blot
    Western blot analysis of Fumarase in MCF-7, Jurkat and Hela lysates using Fumarase antibody.
  • Western blot
    Western blot analysis of FH in K562, Ramos, Jurkat, Hela lysates using Fumarase antibody.
References

Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation., PMID:40528028

Beyond the switch to the biosimilar of natalizumab: What is the impact of changing the JCV test?, PMID:40515642

WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency., PMID:40492997

Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation., PMID:40467630

ANGPTL3: A Breakthrough Target in Treatment for Dyslipidemia and Atherosclerosis., PMID:40467521

Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future., PMID:40463417

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain., PMID:40463049

KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression., PMID:40460200

Streptococcus suis AdcA interacts with factor H and inhibits C3b deposition on the bacteria to participate in complement evasion., PMID:40446560

The Emerging Role of Circulating T Follicular Helper Cells in Dengue Virus Immunity: Balancing Protection and Pathogenesis., PMID:40431664

Delineation of the Human Germinal Centre Immune Landscape Using Multiplex Imaging Analysis., PMID:40421691

T-follicular helper cell profiles differ by malaria antigen and for children compared to adults., PMID:40402846

Safety and efficacy of a novel ANGPTL4 inhibitory antibody for lipid lowering: results from phase 1 and phase 1b/2a clinical studies., PMID:40383129

Effects of Janus kinase inhibitors in adults admitted to hospital due to COVID-19: a systematic review and individual participant data meta-analysis of randomised clinical trials., PMID:40378861

Ravulizumab for generalized Myasthenia Gravis: a multicenter real-life experience., PMID:40366475

An ANGPTL4 inhibitory antibody safely improves lipid profiles in non-human primates., PMID:40360349

Escalation of Germinal Center Responses in Chronic Litomosoides sigmodontis Filarial Infection., PMID:40359324

Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitis., PMID:40338657

Nivolumab plus ifosfamide, carboplatin, and etoposide are a highly effective first salvage regimen in high-risk relapsed/refractory Hodgkin lymphoma., PMID:40313510

A distinctive IGHV3-66 SARS-CoV-2 neutralizing antibody elicited by primary infection with an Omicron variant., PMID:40306272

Pregnancy-related Thrombotic Microangiopathy has a spectrum of underlying causes., PMID:40306205

Effect of felzartamab on the molecular phenotype of antibody-mediated rejection in kidney transplant biopsies., PMID:40301559

Implementation strategies for improving the care of familial hypercholesterolaemia from the International Atherosclerosis Society: next steps in implementation science and practice., PMID:40297674

Deposition of complement regulators on the surface of Plasmodium falciparum merozoites depends on the immune status of the host., PMID:40294075

Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study)., PMID:40292288

Long-Term Efficacy and Safety of Ravulizumab in Adults With Anti-Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis: Final Results From the Phase 3 CHAMPION MG Open-Label Extension., PMID:40241307

Serum fibrinogen is not elevated in patients with myasthenia gravis., PMID:40234551

B cell depletion in lupus nephritis: From disappointments to hopes, despite some concerns., PMID:40220749

Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine., PMID:40189575

Patient-reported outcomes from the MIRASOL trial evaluating mirvetuximab soravtansine versus chemotherapy in patients with folate receptor α-positive, platinum-resistant ovarian cancer: a randomised, open-label, phase 3 trial., PMID:40179908

Nanomechanical systems for the rapid detection of HIV-1 p24 antigen., PMID:40179694

T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses., PMID:40169810

Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis., PMID:40149624

Factor H-related 2 levels dictate FHR dimer composition., PMID:40148491

Common Haplotypes within the Chromosome 1q31.3 Region Determine Systemic Concentrations of the Entire Complement Factor H Protein Family., PMID:40139172

Development and Characterization of Novel ELISAs for the Specific Quantification of the Factor H-Related Proteins 2, 3, 4, and 5., PMID:40139166

Effective long-term treatment with moss-produced factor H by overcoming the antibody response in a mouse model of C3G., PMID:40124383

Human Factor H and anti-Neisserial surface protein A (NspA) antibodies compete for overlapping binding sites on meningococcal NspA., PMID:39992115

Atopic skin inflammation promotes systemic anaphylactic responses via IL-13 signaling in conventional dendritic cells., PMID:39989951

Therapeutic Drug Monitoring for Dose Optimization of Infliximab in Patients With Inflammatory Bowel Disease: An Analysis of Canadian Real-World Data., PMID:39959029

Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination., PMID:39946236

γδ T Cells' Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models., PMID:39944220

Resistance to conventional drug therapy and good response to lomitapide allowed the identification of a novel bi-allelic semi-dominant monogenic HoFH: a case report., PMID:39931866

Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance., PMID:39926597

Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses., PMID:39891019

Improved therapeutic efficacy of a bifunctional anti-C5 mAb-FH SCR1-5 fusion protein over anti-C5 mAb in an accelerated mouse model of C3 glomerulopathy., PMID:39865974

Characterization of Hospital Admissions During Immune Checkpoint Inhibitor Therapy: Insights From the ICOG Study., PMID:39865401

Peptide Inhibitor Assay for Allocating Functionally Important Accessible Sites Throughout a Protein Chain: Restriction Endonuclease EcoRI as a Model Protein System., PMID:39846550

Pharmacokinetic characterization and exposure-response relationship of crovalimab in the COMMODORE 1, 2 and 3 and COMPOSER trials of patients with paroxysmal nocturnal haemoglobinuria., PMID:39835421

Germinal Center B Cells are Uniquely Targeted by Antibody-Suppressor CXCR5+CD8+ T Cells., PMID:39802197

Datasheet

Document Download

Anti-FH Antibody (R3A42).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-FH Antibody (R3A42) [RHC29105]
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