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Anti-FH Antibody (R3A41)

Catalog #:   RHC29104 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2a
Applications: IP, WB
Accession: P07954
Overview

Catalog No.

RHC29104

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a

Clonality

Monoclonal

Tested applications

IP: 1:100-1:200, WB: 1:500-1:1000

Target

Fumarase, HsFH, Fumarate hydratase, mitochondrial, FH

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P07954

Applications

IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3A41

Data Image
  • Immunoprecipitation
    Lane 1: Ramos lysate ; Lane 2: FH immunoprecipitated from Ramos lysate by RHC29104;Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: RHC29104 can immunoprecipitate FH;
  • Western blot
    Western blot analysis using FH mouse mAb against Ramos lysate
References

Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation., PMID:40528028

Beyond the switch to the biosimilar of natalizumab: What is the impact of changing the JCV test?, PMID:40515642

WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency., PMID:40492997

Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation., PMID:40467630

ANGPTL3: A Breakthrough Target in Treatment for Dyslipidemia and Atherosclerosis., PMID:40467521

Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future., PMID:40463417

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain., PMID:40463049

KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression., PMID:40460200

Streptococcus suis AdcA interacts with factor H and inhibits C3b deposition on the bacteria to participate in complement evasion., PMID:40446560

The Emerging Role of Circulating T Follicular Helper Cells in Dengue Virus Immunity: Balancing Protection and Pathogenesis., PMID:40431664

Delineation of the Human Germinal Centre Immune Landscape Using Multiplex Imaging Analysis., PMID:40421691

T-follicular helper cell profiles differ by malaria antigen and for children compared to adults., PMID:40402846

Safety and efficacy of a novel ANGPTL4 inhibitory antibody for lipid lowering: results from phase 1 and phase 1b/2a clinical studies., PMID:40383129

Effects of Janus kinase inhibitors in adults admitted to hospital due to COVID-19: a systematic review and individual participant data meta-analysis of randomised clinical trials., PMID:40378861

Ravulizumab for generalized Myasthenia Gravis: a multicenter real-life experience., PMID:40366475

An ANGPTL4 inhibitory antibody safely improves lipid profiles in non-human primates., PMID:40360349

Escalation of Germinal Center Responses in Chronic Litomosoides sigmodontis Filarial Infection., PMID:40359324

Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitis., PMID:40338657

Nivolumab plus ifosfamide, carboplatin, and etoposide are a highly effective first salvage regimen in high-risk relapsed/refractory Hodgkin lymphoma., PMID:40313510

A distinctive IGHV3-66 SARS-CoV-2 neutralizing antibody elicited by primary infection with an Omicron variant., PMID:40306272

Pregnancy-related Thrombotic Microangiopathy has a spectrum of underlying causes., PMID:40306205

Effect of felzartamab on the molecular phenotype of antibody-mediated rejection in kidney transplant biopsies., PMID:40301559

Implementation strategies for improving the care of familial hypercholesterolaemia from the International Atherosclerosis Society: next steps in implementation science and practice., PMID:40297674

Deposition of complement regulators on the surface of Plasmodium falciparum merozoites depends on the immune status of the host., PMID:40294075

Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study)., PMID:40292288

Long-Term Efficacy and Safety of Ravulizumab in Adults With Anti-Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis: Final Results From the Phase 3 CHAMPION MG Open-Label Extension., PMID:40241307

Serum fibrinogen is not elevated in patients with myasthenia gravis., PMID:40234551

B cell depletion in lupus nephritis: From disappointments to hopes, despite some concerns., PMID:40220749

Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine., PMID:40189575

Patient-reported outcomes from the MIRASOL trial evaluating mirvetuximab soravtansine versus chemotherapy in patients with folate receptor α-positive, platinum-resistant ovarian cancer: a randomised, open-label, phase 3 trial., PMID:40179908

Nanomechanical systems for the rapid detection of HIV-1 p24 antigen., PMID:40179694

T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses., PMID:40169810

Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis., PMID:40149624

Factor H-related 2 levels dictate FHR dimer composition., PMID:40148491

Common Haplotypes within the Chromosome 1q31.3 Region Determine Systemic Concentrations of the Entire Complement Factor H Protein Family., PMID:40139172

Development and Characterization of Novel ELISAs for the Specific Quantification of the Factor H-Related Proteins 2, 3, 4, and 5., PMID:40139166

Effective long-term treatment with moss-produced factor H by overcoming the antibody response in a mouse model of C3G., PMID:40124383

Human Factor H and anti-Neisserial surface protein A (NspA) antibodies compete for overlapping binding sites on meningococcal NspA., PMID:39992115

Atopic skin inflammation promotes systemic anaphylactic responses via IL-13 signaling in conventional dendritic cells., PMID:39989951

Therapeutic Drug Monitoring for Dose Optimization of Infliximab in Patients With Inflammatory Bowel Disease: An Analysis of Canadian Real-World Data., PMID:39959029

Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination., PMID:39946236

γδ T Cells' Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models., PMID:39944220

Resistance to conventional drug therapy and good response to lomitapide allowed the identification of a novel bi-allelic semi-dominant monogenic HoFH: a case report., PMID:39931866

Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance., PMID:39926597

Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses., PMID:39891019

Improved therapeutic efficacy of a bifunctional anti-C5 mAb-FH SCR1-5 fusion protein over anti-C5 mAb in an accelerated mouse model of C3 glomerulopathy., PMID:39865974

Characterization of Hospital Admissions During Immune Checkpoint Inhibitor Therapy: Insights From the ICOG Study., PMID:39865401

Peptide Inhibitor Assay for Allocating Functionally Important Accessible Sites Throughout a Protein Chain: Restriction Endonuclease EcoRI as a Model Protein System., PMID:39846550

Pharmacokinetic characterization and exposure-response relationship of crovalimab in the COMMODORE 1, 2 and 3 and COMPOSER trials of patients with paroxysmal nocturnal haemoglobinuria., PMID:39835421

Germinal Center B Cells are Uniquely Targeted by Antibody-Suppressor CXCR5+CD8+ T Cells., PMID:39802197

Datasheet

Document Download

Anti-FH Antibody (R3A41).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-FH Antibody (R3A41) [RHC29104]
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