Catalog No.
RHC29104
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
IP: 1:100-1:200, WB: 1:500-1:1000
Target
Fumarase, HsFH, Fumarate hydratase, mitochondrial, FH
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P07954
Applications
IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3A41
Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation., PMID:40528028
Beyond the switch to the biosimilar of natalizumab: What is the impact of changing the JCV test?, PMID:40515642
WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency., PMID:40492997
Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation., PMID:40467630
ANGPTL3: A Breakthrough Target in Treatment for Dyslipidemia and Atherosclerosis., PMID:40467521
Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future., PMID:40463417
A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain., PMID:40463049
KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression., PMID:40460200
Streptococcus suis AdcA interacts with factor H and inhibits C3b deposition on the bacteria to participate in complement evasion., PMID:40446560
The Emerging Role of Circulating T Follicular Helper Cells in Dengue Virus Immunity: Balancing Protection and Pathogenesis., PMID:40431664
Delineation of the Human Germinal Centre Immune Landscape Using Multiplex Imaging Analysis., PMID:40421691
T-follicular helper cell profiles differ by malaria antigen and for children compared to adults., PMID:40402846
Safety and efficacy of a novel ANGPTL4 inhibitory antibody for lipid lowering: results from phase 1 and phase 1b/2a clinical studies., PMID:40383129
Effects of Janus kinase inhibitors in adults admitted to hospital due to COVID-19: a systematic review and individual participant data meta-analysis of randomised clinical trials., PMID:40378861
Ravulizumab for generalized Myasthenia Gravis: a multicenter real-life experience., PMID:40366475
An ANGPTL4 inhibitory antibody safely improves lipid profiles in non-human primates., PMID:40360349
Escalation of Germinal Center Responses in Chronic Litomosoides sigmodontis Filarial Infection., PMID:40359324
Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitis., PMID:40338657
Nivolumab plus ifosfamide, carboplatin, and etoposide are a highly effective first salvage regimen in high-risk relapsed/refractory Hodgkin lymphoma., PMID:40313510
A distinctive IGHV3-66 SARS-CoV-2 neutralizing antibody elicited by primary infection with an Omicron variant., PMID:40306272
Pregnancy-related Thrombotic Microangiopathy has a spectrum of underlying causes., PMID:40306205
Effect of felzartamab on the molecular phenotype of antibody-mediated rejection in kidney transplant biopsies., PMID:40301559
Implementation strategies for improving the care of familial hypercholesterolaemia from the International Atherosclerosis Society: next steps in implementation science and practice., PMID:40297674
Deposition of complement regulators on the surface of Plasmodium falciparum merozoites depends on the immune status of the host., PMID:40294075
Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study)., PMID:40292288
Long-Term Efficacy and Safety of Ravulizumab in Adults With Anti-Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis: Final Results From the Phase 3 CHAMPION MG Open-Label Extension., PMID:40241307
Serum fibrinogen is not elevated in patients with myasthenia gravis., PMID:40234551
B cell depletion in lupus nephritis: From disappointments to hopes, despite some concerns., PMID:40220749
Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine., PMID:40189575
Patient-reported outcomes from the MIRASOL trial evaluating mirvetuximab soravtansine versus chemotherapy in patients with folate receptor α-positive, platinum-resistant ovarian cancer: a randomised, open-label, phase 3 trial., PMID:40179908
Nanomechanical systems for the rapid detection of HIV-1 p24 antigen., PMID:40179694
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses., PMID:40169810
Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis., PMID:40149624
Factor H-related 2 levels dictate FHR dimer composition., PMID:40148491
Common Haplotypes within the Chromosome 1q31.3 Region Determine Systemic Concentrations of the Entire Complement Factor H Protein Family., PMID:40139172
Development and Characterization of Novel ELISAs for the Specific Quantification of the Factor H-Related Proteins 2, 3, 4, and 5., PMID:40139166
Effective long-term treatment with moss-produced factor H by overcoming the antibody response in a mouse model of C3G., PMID:40124383
Human Factor H and anti-Neisserial surface protein A (NspA) antibodies compete for overlapping binding sites on meningococcal NspA., PMID:39992115
Atopic skin inflammation promotes systemic anaphylactic responses via IL-13 signaling in conventional dendritic cells., PMID:39989951
Therapeutic Drug Monitoring for Dose Optimization of Infliximab in Patients With Inflammatory Bowel Disease: An Analysis of Canadian Real-World Data., PMID:39959029
Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination., PMID:39946236
γδ T Cells' Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models., PMID:39944220
Resistance to conventional drug therapy and good response to lomitapide allowed the identification of a novel bi-allelic semi-dominant monogenic HoFH: a case report., PMID:39931866
Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance., PMID:39926597
Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses., PMID:39891019
Improved therapeutic efficacy of a bifunctional anti-C5 mAb-FH SCR1-5 fusion protein over anti-C5 mAb in an accelerated mouse model of C3 glomerulopathy., PMID:39865974
Characterization of Hospital Admissions During Immune Checkpoint Inhibitor Therapy: Insights From the ICOG Study., PMID:39865401
Peptide Inhibitor Assay for Allocating Functionally Important Accessible Sites Throughout a Protein Chain: Restriction Endonuclease EcoRI as a Model Protein System., PMID:39846550
Pharmacokinetic characterization and exposure-response relationship of crovalimab in the COMMODORE 1, 2 and 3 and COMPOSER trials of patients with paroxysmal nocturnal haemoglobinuria., PMID:39835421
Germinal Center B Cells are Uniquely Targeted by Antibody-Suppressor CXCR5+CD8+ T Cells., PMID:39802197
For research use only. Not for human or drug use.
