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Research Grade Camrelizumab (DHH02211)

Host species:Humanized
Isotype:IgG4-kappa
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DHH02211

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG4-kappa

Clonality

Monoclonal

Target

Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279

Concentration

12.5 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q15116

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

SHR-1210, CAS: 1798286-48-2

Clone ID

Camrelizumab

Data Image
  • Bioactivity
    Detects Human CD279/PDCD1/PD1 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Camrelizumab
References

Camrelizumab: First Global Approval, PMID: 31313098

Camrelizumab versus investigator's choice of chemotherapy as second-line therapy for advanced or metastatic oesophageal squamous cell carcinoma (ESCORT): a multicentre, randomised, open-label, phase 3 study, PMID: 32416073

Camrelizumab plus carboplatin and pemetrexed versus chemotherapy alone in chemotherapy-naive patients with advanced non-squamous non-small-cell lung cancer (CameL): a randomised, open-label, multicentre, phase 3 trial, PMID: 33347829

Camrelizumab in patients with previously treated advanced hepatocellular carcinoma: a multicentre, open-label, parallel-group, randomised, phase 2 trial, PMID: 32112738

Addition of Low-Dose Decitabine to Anti-PD-1 Antibody Camrelizumab in Relapsed/Refractory Classical Hodgkin Lymphoma, PMID: 31039052

N-glycosylation of PD-1 promotes binding of camrelizumab, PMID: 33063473

The clinical application of camrelizumab on advanced hepatocellular carcinoma, PMID: 32762583

Camrelizumab in Combination with Apatinib in Patients with Advanced Hepatocellular Carcinoma (RESCUE): A Nonrandomized, Open-label, Phase II Trial, PMID: 33087333

Camrelizumab Plus Apatinib in Extensive-Stage SCLC (PASSION): A Multicenter, Two-Stage, Phase 2 Trial, PMID: 33166719

Camrelizumab Plus Apatinib in Patients With Advanced Cervical Cancer (CLAP): A Multicenter, Open-Label, Single-Arm, Phase II Trial, PMID: 33052760

Camrelizumab (SHR-1210) alone or in combination with gemcitabine plus cisplatin for nasopharyngeal carcinoma: results from two single-arm, phase 1 trials, PMID: 30213452

Camrelizumab plus gemcitabine and oxaliplatin (GEMOX) in patients with advanced biliary tract cancer: a single-arm, open-label, phase II trial, PMID: 33172881

Effectiveness and safety of toripalimab, camrelizumab, and sintilimab in a real-world cohort of hepatitis B virus associated hepatocellular carcinoma patients, PMID: 33241036

Reactive cutaneous capillary endothelial proliferation in advanced hepatocellular carcinoma patients treated with camrelizumab: data derived from a multicenter phase 2 trial, PMID: 32393323

A Single-Arm, Multicenter, Phase II Study of Camrelizumab in Relapsed or Refractory Classical Hodgkin Lymphoma, PMID: 31420358

Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy, PMID: 33323401

Phase II clinical trial using camrelizumab combined with apatinib and chemotherapy as the first-line treatment of advanced esophageal squamous cell carcinoma, PMID: 33314747

Efficacy and Safety of SBRT Combined With Camrelizumab and Apatinib in HCC Patients With PVTT: Study Protocol of a Randomized Controlled Trial, PMID: 32984021

Efficacy and safety of camrelizumab combined with apatinib in advanced triple-negative breast cancer: an open-label phase II trial, PMID: 32448804

Apatinib plus camrelizumab (anti-PD1 therapy, SHR-1210) for advanced osteosarcoma (APFAO) progressing after chemotherapy: a single-arm, open-label, phase 2 trial, PMID: 32376724

Camrelizumab-targeting a novel PD-1 epitope to treat hepatocellular carcinoma, PMID: 33437813

Camrelizumab combined with microwave ablation improves the objective response rate in advanced non-small cell lung cancer, PMID: 31939448

Salvage camrelizumab plus apatinib for relapsed esophageal neuroendocrine carcinoma after esophagectomy: a case report and review of the literature, PMID: 33092443

Camrelizumab for nasopharyngeal carcinoma: a new hope?, PMID: 30213451

Camrelizumab plus apatinib successfully treated a patient with advanced esophageal squamous cell carcinoma, PMID: 32814482

A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia, PMID: 32256049

Camrelizumab Plus Gemcitabine, Vinorelbine, and Pegylated Liposomal Doxorubicin in Relapsed/Refractory Primary Mediastinal B-Cell Lymphoma: A Single-Arm, Open-Label, Phase II Trial, PMID: 32499235

Correction to: Camrelizumab: First Global Approval, PMID: 31446564

Camrelizumab in advanced or metastatic solid tumour patients with DNA mismatch repair deficient or microsatellite instability high: an open-label prospective pivotal trial, PMID: 32623573

Rechallenge of camrelizumab in non-small-cell lung cancer patients treated previously with camrelizumab and microwave ablation, PMID: 33004770

Antibodies to watch in 2019, PMID: 30516432

Experience With Anti-PD-1 Antibody, Camrelizumab, Monotherapy for Biliary Tract Cancer Patients and Literature Review, PMID: 33308041

Camrelizumab (SHR-1210) leading to reactive capillary hemangioma in the gingiva: A case report, PMID: 32110675

Population pharmacokinetics of the anti-PD-1 antibody camrelizumab in patients with multiple tumor types and model-informed dosing strategy, PMID: 33154554

Anti-PD-1 antibody camrelizumab plus doxorubicin showed durable response in pulmonary sarcomatoid carcinoma: Case report and literature review, PMID: 32776600

Anti-PD-1 Antibody SHR-1210 Combined with Apatinib for Advanced Hepatocellular Carcinoma, Gastric, or Esophagogastric Junction Cancer: An Open-label, Dose Escalation and Expansion Study, PMID: 30348638

Emerging agents and regimens for hepatocellular carcinoma, PMID: 31655607

Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer, PMID: 30755403

Immune-Related Adverse Events Mimicking Behcet's Disease in a Gastric Cancer Patient Following Camrelizumab Treatment, PMID: 32602470

A large randomized clinical trial is necessary to establish the role of camrelizumab in hepatocellular carcinoma, PMID: 33178785

Immune checkpoint inhibitor-related pneumonitis induced by camrelizumab: a case report and review of literature, PMID: 34044548

Comparative safety and efficacy of anti-PD-1 monotherapy, chemotherapy alone, and their combination therapy in advanced nasopharyngeal carcinoma: findings from recent advances in landmark trials, PMID: 31238988

Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with hepatocellular carcinoma, PMID: 31337439

Camrelizumab versus placebo in combination with gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (CAPTAIN-1st): a multicentre, randomised, double-blind, phase 3 trial, PMID: 34174189

Improved clinical outcome in a randomized phase II study of anti-PD-1 camrelizumab plus decitabine in relapsed/refractory Hodgkin lymphoma, PMID: 33820822

Camrelizumab efficacious in NPC, PMID: 34253913

Immune checkpoint inhibitors in advanced nasopharyngeal carcinoma: Beyond an era of chemoradiation?, PMID: 31950498

Camrelizumab plus famitinib to treat RCC, PMID: 34453154

Novel Therapeutics for Recurrent Cervical Cancer: Moving Towards Personalized Therapy, PMID: 31939072

Protocol for a randomized controlled trial of perioperative S-1 plus oxaliplatin combined with apatinib and camrelizumab in patients with resectable, locally advanced gastric or gastroesophageal junction adenocarcinoma, PMID: 33490196

Datasheet

Document Download

Research Grade Camrelizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Camrelizumab [DHH02211]
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