Genomic and Phenotypic Characterization of CHO 4BGD Cells with Quad Knockout and Overexpression of Two Housekeeping Genes That Allow for Metabolic Selection and Extended Fed-Batch Culturing., PMID:40422195
Development of a Dihydrofolate Reductase Selection System for Saccharomyces boulardii., PMID:40076696
Trypanosoma cruzi infection in American black bears (Ursus americanus): A case report in a cub from California and serologic survey for exposure in wild black bears from several states., PMID:39550185
Prodrug nanotherapy demonstrates in vivo anticryptosporidial efficacy in a mouse model of chronic Cryptosporidium infection., PMID:39372445
Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform., PMID:38801272
Targeted Drug Delivery by MMAE Farnesyl-Bioconjugated Multivalent Chemically Self-Assembled Nanorings Induces Potent Receptor-Dependent Immunogenic Cell Death., PMID:38701361
Accelerated generation of gene-engineered monoclonal CHO cell lines using FluidFM nanoinjection and CRISPR/Cas9., PMID:38651269
Sustained clinical benefit of malaria chemoprevention with sulfadoxine-pyrimethamine (SP) in pregnant women in a region with high SP resistance markers., PMID:38574776
Effect of adenosine and cordycepin on recombinant antibody production yields in two different Chinease hamster ovary cell lines., PMID:37985175
Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium., PMID:36562657
Use of Leishmania major parasites expressing a recombinant Trypanosoma cruzi antigen as live vaccines against Chagas disease., PMID:36523834
Hybrid cell line development system utilizing site-specific integration and methotrexate-mediated gene amplification in Chinese hamster ovary cells., PMID:36185448
Evaluation of site-specific methylation of the CMV promoter and its role in CHO cell productivity of a recombinant monoclonal antibody., PMID:35719211
QbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primary requirements of comparability to Keytruda®., PMID:35378209
Enhancement of anti-TNFα monoclonal antibody production in CHO cells through the use of UCOE and DHFR elements in vector construction and the optimization of cell culture media., PMID:34427158
A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells., PMID:34386349
A phase 1 study of NY-ESO-1 vaccine + anti-CTLA4 antibody Ipilimumab (IPI) in patients with unresectable or metastatic melanoma., PMID:33796406
Comprehensive characterization of dihydrofolate reductase-mediated gene amplification for the establishment of recombinant human embryonic kidney 293 cells producing monoclonal antibodies., PMID:33314785
Expression of recombinant classical swine fever virus E2 glycoprotein by endogenous Txnip promoter in stable transgenic CHO cells., PMID:32774204
Construction of a Mammalian IRES-based Expression Vector to Amplify a Bispecific Antibody; Blinatumomab., PMID:32184875
Complexes Formed via Bioconjugation of Genetically Modified TMV Particles with Conserved Influenza Antigen: Synthesis and Characterization., PMID:32093598
Attenuated glutamine synthetase as a selection marker in CHO cells to efficiently isolate highly productive stable cells for the production of antibodies and other biologics., PMID:31043114
Incorporation of CD40 ligand or granulocyte-macrophage colony stimulating factor into Hantaan virus (HTNV) virus-like particles significantly enhances the long-term immunity potency against HTNV infection., PMID:30657443
Recombinant Antibody Production in CHO and NS0 Cells: Differences and Similarities., PMID:30499081
An IRES-Mediated Tricistronic Vector for Efficient Generation of Stable, High-Level Monoclonal Antibody Producing CHO DG44 Cell Lines., PMID:30196505
Application of microRNA Targeted 3'UTRs to Repress DHFR Selection Marker Expression for Development of Recombinant Antibody Expressing CHO Cell Pools., PMID:29981248
Gene variants in the folate pathway are associated with increased levels of folate receptor autoantibodies., PMID:29732742
Using a Dihydrofolate Reductase-Based Strategy for Producing the Biosimilar Version of Pertuzumab in CHO-S Cells., PMID:29437532
Identification and functional characterization of type II toxin/antitoxin systems in Aggregatibacter actinomycetemcomitans., PMID:29319934
A novel enediyne-integrated antibody-drug conjugate shows promising antitumor efficacy against CD30+ lymphomas., PMID:29316337
Proteomic analysis of CHO cell lines producing high and low quantities of a recombinant antibody before and after selection with methotrexate., PMID:29137976
Optimized Selection Marker and CHO Host Cell Combinations for Generating High Monoclonal Antibody Producing Cell Lines., PMID:29090854
Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB., PMID:28898075
Impact of Signal Peptides on Furin-2A Mediated Monoclonal Antibody Secretion in CHO Cells., PMID:28727292
Proteome Analysis of Rheumatoid Arthritis Gut Mucosa., PMID:27627584
Identification of regulatory motifs in the CHO genome for stable monoclonal antibody production., PMID:27544513
Disruption of the gene C12orf35 leads to increased productivities in recombinant CHO cell lines., PMID:27183150
Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells., PMID:26989081
In Vivo Evaluation of Site-Specifically PEGylated Chemically Self-Assembled Protein Nanostructures., PMID:26985775
miR-192 suppresses leptomeningeal dissemination of medulloblastoma by modulating cell proliferation and anchoring through the regulation of DHFR, integrins, and CD47., PMID:26506238
Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines., PMID:25963793
A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium., PMID:25900220
Synthetic antibodies and peptides recognizing progressive multifocal leukoencephalopathy-specific point mutations in polyomavirus JC capsid viral protein 1., PMID:25879139
CEA/CD3 bispecific antibody MEDI-565/AMG 211 activation of T cells and subsequent killing of human tumors is independent of mutations commonly found in colorectal adenocarcinomas., PMID:25484061
Construction of a chimeric secretory IgA and its neutralization activity against avian influenza virus H5N1., PMID:24741594
[The expression of interferon-lambda1 in CHO cell]., PMID:24319953
Cell line profiling to improve monoclonal antibody production., PMID:24249214
Construction and characterization of a novel chimeric antibody c3C7 specific for the integrin αIIbβ3 complex., PMID:24113827
Transcriptome dynamics of transgene amplification in Chinese hamster ovary cells., PMID:24108600
Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli., PMID:23911607
For research use only. Not for human or drug use.
