Catalog No.
RHB83503
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, IP: 1:100-1:200, WB: 1:500-1:1000
Target
p21-activated kinase 4, Serine/threonine-protein kinase PAK 4, KIAA1142, PAK-4, PAK4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O96013
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2W60
Determinants of response and molecular dynamics in HER2+ER+ breast cancers from the NA-PHER2 trial receiving HER2-targeted and endocrine therapies., PMID:40038334
PAK4 inhibition improves PD1 blockade immunotherapy in prostate cancer by increasing immune infiltration., PMID:36509363
The Combined Use of Orf Virus and PAK4 Inhibitor Exerts Anti-tumor Effect in Breast Cancer., PMID:35401439
Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model., PMID:34275493
Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma., PMID:32916126
Anti-Cancer Activity of PAK4/NAMPT Inhibitor and Programmed Cell Death Protein-1 Antibody in Kidney Cancer., PMID:35224510
Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion., PMID:30622337
[The expression of moesin, p21-activated kinase 4 (PAK 4), matrix metalloproteinases (MMP 2, MMP 9), and CD34 in the eutopic and ectopic endometrium in adenomyosis]., PMID:30585588
PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells., PMID:27765920
Silencing Aurora-A with siRNA inhibits cell proliferation in human lung adenocarcinoma cells., PMID:27571708
Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth., PMID:27390344
Study on the expression of PAK4 and P54 protein in breast cancer., PMID:27297086
Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma., PMID:23254288
Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma., PMID:21325635
Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors., PMID:20686178
Functional protein kinase arrays reveal inhibition of p-21-activated kinase 4 by alpha-synuclein oligomers., PMID:17883396
Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1., PMID:16505058
PAK4 kinase is essential for embryonic viability and for proper neuronal development., PMID:14517283
Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines., PMID:11668177
For research use only. Not for human or drug use.
