Catalog No.
RHB48602
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
IHC: 1:20-1:100
Target
Nuclear factor of activated T-cells 5, TonEBP, Tonicity-responsive enhancer-binding protein, NFAT5, TONEBP, KIAA0827, T-cell transcription factor NFAT5, NF-AT5, TonE-binding protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O94916
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2W08
Low-Salt Diet Reduces Anti-CTLA4 Mediated Systemic Immune-Related Adverse Events while Retaining Therapeutic Efficacy against Breast Cancer., PMID:35741331
Interleukin-20 is involved in dry eye disease and is a potential therapeutic target., PMID:35681232
Low-Salt Diet Attenuates B-Cell- and Myeloid-Cell-Driven Experimental Arthritides by Affecting Innate as Well as Adaptive Immune Mechanisms., PMID:34925335
MicroRNA-223 modulates the IL-4-medicated macrophage M2-type polarization to control the progress of sepsis., PMID:34162147
Ex Vivo High Salt Activated Tumor-Primed CD4+T Lymphocytes Exert a Potent Anti-Cancer Response., PMID:33918403
Description of a Novel Mechanism Possibly Explaining the Antiproliferative Properties of Glucocorticoids in Duchenne Muscular Dystrophy Fibroblasts Based on Glucocorticoid Receptor GR and NFAT5., PMID:33287327
The Impact of Hyperosmolality on Activation and Differentiation of B Lymphoid Cells., PMID:31057551
Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5., PMID:31053298
Identification of NFAT5 as a transcriptional regulator of the EDN1 gene in collecting duct., PMID:30623723
NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells., PMID:30413537
Sodium chloride inhibits IFN-γ, but not IL-4, production by invariant NKT cells., PMID:29345057
Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression., PMID:27807832
Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5., PMID:27479742
Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis., PMID:26984885
Involvement of TonEBP/NFAT5 in osmoadaptative response of human retinal pigmented epithelial cells to hyperosmolar stress., PMID:26912969
Integrin α6β4 Promotes Autocrine Epidermal Growth Factor Receptor (EGFR) Signaling to Stimulate Migration and Invasion toward Hepatocyte Growth Factor (HGF)., PMID:26381405
Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C δ in a mouse model of diabetic retinopathy., PMID:24631337
Immune cells control skin lymphatic electrolyte homeostasis and blood pressure., PMID:23722907
NFAT5-dependent expression of AQP4 in astrocytes., PMID:23180003
The protection of acetylcholinesterase inhibitor on β-amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells., PMID:23119107
Effect of Poria cocos on hypertonic stress-induced water channel expression and apoptosis in renal collecting duct cells., PMID:22414475
NF-AT5 is a critical regulator of inflammatory arthritis., PMID:21717420
EGF receptor signaling is involved in expression of osmoprotective TonEBP target gene aldose reductase under hypertonic conditions., PMID:19225051
Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5., PMID:19211510
Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus., PMID:18606815
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells., PMID:18436816
Downregulation of NFAT5 by RNA interference reduces monoclonal antibody productivity of hybridoma cells., PMID:17310218
Identification of epithelial auto-antigens associated with periodontal disease., PMID:15654832
NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment., PMID:15247420
For research use only. Not for human or drug use.
