Catalog No.
RHA85304
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
Parkin, PARK2, Parkinson juvenile disease protein 2, E3 ubiquitin-protein ligase parkin, Parkin RBR E3 ubiquitin-protein ligase, PRKN, Parkinson disease protein 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O60260
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2V15
SQYC formula improves the efficacy of PD-1 monoclonal antibodies in MSS colorectal cancer by regulating dendritic cell mitophagy via the PINK1-Parkin pathway., PMID:39826284
An Inducible Luminescent System to Explore Parkinson's Disease-Associated Genes., PMID:39273438
Protective effects of Parkin knockout on asthma-induced changes in juvenile mice: inflammation, airway resistance, and oxidative stress., PMID:39269783
Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes., PMID:38987265
Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue., PMID:38802071
GRAF1 Acts as a Downstream Mediator of Parkin to Regulate Mitophagy in Cardiomyocytes., PMID:38474413
Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue., PMID:38293125
Potential of PINK1 and PARKIN Proteins as Biomarkers for Active Multiple Sclerosis: A Japanese Cohort Study., PMID:34421896
Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites., PMID:33694021
Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC., PMID:33685343
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes., PMID:33404293
Assessing Chondrocyte Status by Immunofluorescence-Mediated Localization of Parkin Relative to Mitochondria., PMID:33315205
Negative α-synuclein pathology in the submandibular gland of patients carrying PRKN pathogenic variants., PMID:33166806
Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples., PMID:33112198
Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy., PMID:33087821
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets., PMID:33082525
The Michael J. Fox Foundation for Parkinson's Research Strategy to Advance Therapeutic Development of PINK1 and Parkin., PMID:31344817
Macrophage migration inhibitory factor enhances influenza-associated mortality in mice., PMID:31292300
Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392
Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells., PMID:30754623
PINK1/parkin-mediated mitophagy pathway is related to neuroprotection by carnosic acid in SH-SY5Y cells., PMID:30707903
PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism., PMID:30100261
Structure of PINK1 in complex with its substrate ubiquitin., PMID:29160309
Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity., PMID:28761318
Immunocytochemical Monitoring of PINK1/Parkin-Mediated Mitophagy in Cultured Cells., PMID:28361483
Induction of PINK1/Parkin-Mediated Mitophagy., PMID:28361482
Modulation of ARTS and XIAP by Parkin Is Associated with Carnosic Acid Protects SH-SY5Y Cells against 6-Hydroxydopamine-Induced Apoptosis., PMID:28224479
Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects., PMID:27846363
Proteomic Analysis of Parkin Isoforms Expression in Different Rat Brain Areas., PMID:27601173
A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis., PMID:27754761
Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity., PMID:27348524
Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis., PMID:27279371
Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia., PMID:27270321
Carnosic Acid Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells by Inducing Autophagy Through an Enhanced Interaction of Parkin and Beclin1., PMID:27013469
Ethanol-induced mitophagy in liver is associated with activation of the PINK1-Parkin pathway triggered by oxidative DNA damage., PMID:26935412
Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains., PMID:26465922
Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models., PMID:26224857
(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation., PMID:26162776
Expression pattern of parkin isoforms in lung adenocarcinomas., PMID:25656612
Proteomic analysis of cerebrospinal fluid in Alzheimer's disease: wanted dead or alive., PMID:25428253
Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN., PMID:24669285
Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes., PMID:24516131
Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice., PMID:24192137
Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination., PMID:24023840
Declines in Drp1 and parkin expression underlie DNA damage-induced changes in mitochondrial length and neuronal death., PMID:23345212
Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat., PMID:22710069
Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells., PMID:21508222
PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis., PMID:21139416
Parkin is protective against proteotoxic stress in a transgenic zebrafish model., PMID:20689587
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1., PMID:20098416
For research use only. Not for human or drug use.
