Catalog No.
RHA73101
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
Zinc finger protein SNAI2, Neural crest transcription factor Slug, Protein snail homolog 2, SLUG, SLUGH, SNAI2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O43623
Applications
ELISA, FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2U97
EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer., PMID:40121428
Slug enables redox-sensitive trans-activation of LRP1 by COUP-TFII: Implication in antifibrotic intervention in the kidneys., PMID:36682522
Pirfenidone suppressed triple-negative breast cancer metastasis by inhibiting the activity of the TGF-β/SMAD pathway., PMID:36651490
Regorafenib inhibits epithelial-mesenchymal transition and suppresses cholangiocarcinoma metastasis via YAP1-AREG axis., PMID:35449153
EMT-mediated regulation of CXCL1/5 for resistance to anti-EGFR therapy in colorectal cancer., PMID:35173310
Neutrophil extracellular traps drive epithelial-mesenchymal transition of human colon cancer., PMID:34939675
Analysis of Several Pathways for Efficient Killing of Prostate Cancer Stem Cells: A Central Role of NF-κB RELA., PMID:34445612
RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGFβ1 in the Suppression of Cell Motility., PMID:33260366
Breast tumour cell subpopulations with expression of the MYC and OCT4 proteins., PMID:33037978
SNAIL expression correlates with the translocation of syndecan‑1 intracellular domain into the nucleus in prostate cancer cell lines., PMID:32124938
SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis., PMID:31582836
Differential expression profiles of conserved Snail transcription factors in the mouse testis., PMID:29381885
Long noncoding RNA BLACAT2 promotes bladder cancer-associated lymphangiogenesis and lymphatic metastasis., PMID:29355840
LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells., PMID:29269400
Tbx18-positive cells differentiated from murine ES cells serve as proepicardial progenitors to give rise to vascular smooth muscle cells and fibroblasts., PMID:28794400
Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition., PMID:28286209
The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200., PMID:28197390
Nuclearly translocated insulin-like growth factor 1 receptor phosphorylates histone H3 at tyrosine 41 and induces SNAI2 expression via Brg1 chromatin remodeling protein., PMID:27275536
Gastrulation EMT Is Independent of P-Cadherin Downregulation., PMID:27097030
The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition., PMID:26876487
E-cadherin expression in obesity-associated, Kras-initiated pancreatic ductal adenocarcinoma in mice., PMID:26297056
Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3., PMID:25732600
CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling., PMID:25356755
Expression and localization of transcription factors SNAIL and SLUG in mouse ovaries and pre-implantation embryos., PMID:25092544
MicroRNA-328 inhibits renal tubular cell epithelial-to-mesenchymal transition by targeting the CD44 in pressure-induced renal fibrosis., PMID:24919189
TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling., PMID:24622514
Angiogenic sprouting is regulated by endothelial cell expression of Slug., PMID:24554431
Caveolin-1 deficiency induces spontaneous endothelial-to-mesenchymal transition in murine pulmonary endothelial cells in vitro., PMID:23195429
Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion., PMID:23054398
Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin)., PMID:22992620
Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells., PMID:22833345
Slug, a unique androgen-regulated transcription factor, coordinates androgen receptor to facilitate castration resistance in prostate cancer., PMID:22745193
CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer., PMID:22210108
E-cadherin, as a negative regulator of invasive behavior of human trophoblast cells, is down-regulated by cyclosporin A via epidermal growth factor/extracellular signal-regulated protein kinase signaling pathway., PMID:20427760
Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells., PMID:20139075
SNAI1 and SNAI2 are asymmetrically expressed at the 2-cell stage and become segregated to the TE in the mouse blastocyst., PMID:20046880
Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer., PMID:19502595
Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis., PMID:19462441
Expression of transcriptional repressor Slug gene in mouse endometrium and its effect during embryo implantation., PMID:19172233
Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype., PMID:19087274
Transforming growth factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells., PMID:17525203
A new model of anterior subcapsular cataract: involvement of TGFbeta/Smad signaling., PMID:16807527
Expression and nuclear localization of Snail, an E-cadherin repressor, in adenocarcinomas of the upper gastrointestinal tract., PMID:16328348
For research use only. Not for human or drug use.
