Catalog No.
RHA62001
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:25-1:200
Target
Hepatocyte growth factor activator inhibitor type 1, HAI-1, SPINT1, HAI1, Kunitz-type protease inhibitor 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O43278
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2U82
Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1., PMID:35020274
The protective role of estrogen on endothelial and glycocalyx barriers after shock conditions: A microfluidic study., PMID:32988619
Proteomic markers with prognostic impact on outcome of chronic lymphocytic leukemia patients under chemo-immunotherapy: results from the HOVON 109 study., PMID:32781097
Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin., PMID:29438412
Engineering a potent inhibitor of matriptase from the natural hepatocyte growth factor activator inhibitor type-1 (HAI-1) protein., PMID:29386351
Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment., PMID:27992572
Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation., PMID:27043831
Differential subcellular localization renders HAI-2 a matriptase inhibitor in breast cancer cells but not in mammary epithelial cells., PMID:25786220
A Grhl2-dependent gene network controls trophoblast branching morphogenesis., PMID:25758223
Imaging a functional tumorigenic biomarker in the transformed epithelium., PMID:23248318
Expression of hepatocyte growth factor activator inhibitor type 1 in human hepatocellular carcinoma and postoperative outcomes., PMID:20213201
Imbalance in the pro-hepatocyte growth factor activation system in bleomycin-induced lung fibrosis in mice., PMID:19448157
Zymogen activation, inhibition, and ectodomain shedding of matriptase., PMID:17981575
Exploration of target molecules for prostate cancer gene therapy., PMID:17516570
Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway., PMID:17389401
Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain., PMID:17344310
Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth., PMID:17174946
The cytotrophoblast layer of human chorionic villi becomes thinner but maintains its structural integrity during gestation., PMID:17035639
Defect of pro-hepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis., PMID:16574935
Identification of antibodies against HAI-1 and integrin alpha6beta4 as immunohistochemical markers of human villous cytotrophoblast., PMID:16495474
[Expression of GST-HAI-1 fusion protein and development of monoclonal antibody against human hepatocyte growth factor activator inhibitor 1]., PMID:15968977
HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease., PMID:15800053
Paradoxically enhanced immunoreactivity of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in cancer cells at the invasion front., PMID:15471558
The hepatocyte growth factor regulatory factors in human breast cancer., PMID:14734471
A positive immunoselection method to isolate villous cytotrophoblast cells from first trimester and term placenta to high purity., PMID:12657516
Tissue microarray analysis of hepatocyte growth factor/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node-negative breast cancer., PMID:12615728
Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor., PMID:11231297
Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta., PMID:11201608
Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma., PMID:11085539
Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form., PMID:10544273
Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues. Cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues., PMID:10219059
White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues., PMID:9743567
For research use only. Not for human or drug use.
