Catalog No.
VMC27702
Species reactivity
Mouse
Host species
Armenian hamster
Isotype
IgG1
Clonality
Monoclonal
Target
T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, Cd3e, T-cell surface glycoprotein CD3 epsilon chain
Concentration
1 mg/ml
Endotoxin level
< 1 EU/mg as determined by LAL test.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
ELISA, FCM, IF, In vitro T cell Stimulation/Activation, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
145-2C11
T cell memory alters pulmonary inflammatory responses to cecal ligation and puncture., PMID:40475466
Development of a CD3ε mAb that can identify and in vitro activate T cells in large yellow croaker (Larimichthyscrocea)., PMID:40449701
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency., PMID:40445758
Butyrate-producing bacteria in pregnancy maintenance: mitigating dysbiosis-induced preterm birth., PMID:40355924
Molecular Imaging of B7-H3-Targeting Bispecific T Cell-Engaging Antibody MGD009 in Glioblastoma Models., PMID:40183579
JNJ-78306358, a first-in-class bispecific T cell engaging antibody targeting CD3 and HLA-G., PMID:40060890
Allosteric Changes Underlie the Outside-In Transmission of Activatory Signals in the TCR., PMID:39754405
In situ staining with antibodies cross-reactive in pigs, cattle, and white-tailed deer facilitates understanding of biological tissue status and immunopathology., PMID:39719720
In situ cell-surface conformation of the TCR-CD3 signaling complex., PMID:39511422
Cis-interaction between CD52 and T cell receptor complex interferes with CD4+ T cell activation in acute decompensation of cirrhosis., PMID:39276679
Synthesis and Activity of T-Cell Tumor-Directing MegaMolecules., PMID:39167468
Structure of a fully assembled γδ T cell antigen receptor., PMID:39146975
Optimizing the Design and Geometry of T Cell-Engaging Bispecific Antibodies Targeting CEA in Colorectal Cancer., PMID:38638035
ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion., PMID:38614099
A pivotal decade for bispecific antibodies?, PMID:38465614
CD19-CD28: an affinity-optimized CD28 agonist for combination with glofitamab (CD20-TCB) as off-the-shelf immunotherapy., PMID:38437725
BR109, a Novel Fully Humanized T-Cell-Engaging Bispecific Antibody with GPRC5D Binding, Has Potent Antitumor Activities in Multiple Myeloma., PMID:38136320
Identification of novel targets for immunotherapies in subsets of patients with diffuse large B-cell lymphoma (DLBCL)., PMID:37964473
A PD-L1xCD3 bispecific nanobody as a novel T-cell engager in treating PD-L1 overexpression melanoma., PMID:37722180
Regulatory Rheumatoid Factor is Specific to PD-1 and Uses PD-1 Pathway to Control CD4 T Lymphocytes., PMID:37615124
CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression., PMID:37586770
Activation of T Lymphocytes with Anti-PDL1-BiTE in the Presence of Adipose-Derived Mesenchymal Stem Cells (ASCs)., PMID:39282109
Preclinical characterization of ISB 1342, a CD38 × CD3 T-cell engager for relapsed/refractory multiple myeloma., PMID:37192303
NAV-003, a bispecific antibody targeting a unique mesothelin epitope and CD3ε with improved cytotoxicity against humoral immunosuppressed tumors., PMID:37146241
Development of Porcine Monoclonal Antibodies with In Vitro Neutralizing Activity against Classical Swine Fever Virus from C-Strain E2-Specific Single B Cells., PMID:37112845
Human Antibody VH Domains Targeting GPNMB and VCAM-1 as Candidate Therapeutics for Cancers., PMID:37067377
CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells., PMID:37041225
Aberrant expression of T cell receptors in monocyte/macrophage RAW 264.7 cells: FCγRII/III compensates the need for CD3., PMID:37028131
Structure-based engineering of a novel CD3ε-targeting antibody for reduced polyreactivity., PMID:36991534
Lipid Nanoparticle Delivery System for mRNA Encoding B7H3-redirected Bispecific Antibody Displays Potent Antitumor Effects on Malignant Tumors., PMID:36403209
Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells., PMID:36305874
Inverted direct allorecognition triggers early donor-specific antibody responses after transplantation., PMID:36130013
Spatial requirements for ITAM signaling in an intracellular natural killer cell model membrane., PMID:35933027
High-fat diet blunts T-cell responsiveness in Nile tilapia., PMID:35863514
Immunohistochemical analysis of the thymus in newborn and adult yaks (Bos grunniens)., PMID:35661993
TCR-mimic bispecific antibodies to target the HIV-1 reservoir., PMID:35394875
Differential activation of chicken gamma delta T cells from different tissues by Toll-like receptor 3 or 21 ligands., PMID:35271861
Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model., PMID:35241687
Recent Advances in the Diagnosis and Treatment of Natural Killer Cell Malignancies., PMID:35158865
T cell activation and IFNγ modulate organ dysfunction in LPS-mediated inflammation., PMID:35141943
IgD ligation allows peritoneal cavity B cell proliferation., PMID:35077917
Blocking GM-CSF receptor α with mavrilimumab reduces infiltrating cells, pro-inflammatory markers and neoangiogenesis in ex vivo cultured arteries from patients with giant cell arteritis., PMID:35045965
CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors., PMID:35039463
Structural arrangement of the VH and VL domains in the COBRA™ T-cell engaging single-chain diabody., PMID:35005430
Colorectal Cancer Progression Is Potently Reduced by a Glucose-Free, High-Protein Diet: Comparison to Anti-EGFR Therapy., PMID:34830971
Bispecific T-Cell Engagers Targeting Membrane-Bound IgE., PMID:34829798
Juzentaihoto Exerts Anti-Allergic Effects by Inhibiting Effector T-Cell Activation and Inducing and/or Activating Regulatory T Cells in a Murine Model of Contact Hypersensitivity., PMID:34818253
Rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells., PMID:34725504
The role of IP-10 and its receptor CXCR3 in early pregnancy., PMID:34655920
Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3+ NK Cell Subset with a Bcl11b-Regulated T Cell Signature., PMID:34625521
For research use only. Not for human or drug use.
