Catalog No.
YXX25501
Expression system
E. coli
Species
Neisseria meningitidis (strain alpha14)
Protein length
Met1-Asp129
Predicted molecular weight
16.5 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
C6S5G8
Applications
ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Putative type IV pilin protein, NMO_0429, pilin protein
Two different and robustly modeled DNA binding modes of Competence Protein ComP - systematic modeling with AlphaFold 3, RoseTTAFold2NA, Chai-1 and re-docking in HADDOCK., PMID:40338866
Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms., PMID:38499587
Type IV pilus retraction is required for Neisseria musculi colonization and persistence in a natural mouse model of infection., PMID:38084997
High-Frequency Changes in Pilin Glycosylation Patterns during Neisseria meningitidis Serogroup a Meningitis Outbreaks in the African Meningitis Belt., PMID:37467082
Analysis of Bacterial Phosphorylcholine-Related Genes Reveals an Association between Type-Specific Biosynthesis Pathways and Biomolecules Targeted for Phosphorylcholine Modification., PMID:37436144
Variable disruption of epithelial monolayers by Neisseria meningitidis carriage isolates of the hypervirulent MenW cc11 and MenY cc23 lineages., PMID:36821361
Piperidine-based natural products targeting Type IV pili antivirulence: A computational approach., PMID:36463631
Pilus PilA of the naturally competent HACEK group pathogen Aggregatibacter actinomycetemcomitans stimulates human leukocytes and interacts with both DNA and proinflammatory cytokines., PMID:36374775
Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe Can Reveal Signalling Pathways in Endothelial Cells, and a Unique Mode of Receptor Activation Involving Its N-Terminal Glycan Chains., PMID:35586623
Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities., PMID:35471082
The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus., PMID:34725157
Lactate-Induced Dispersal of Neisseria meningitidis Microcolonies Is Mediated by Changes in Cell Density and Pilus Retraction and Is Influenced by Temperature Change., PMID:34125601
Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model., PMID:33592056
Construction of a complete set of Neisseria meningitidis mutants and its use for the phenotypic profiling of this human pathogen., PMID:33139723
Transmission Dynamics and Microevolution of Neisseria meningitidis During Carriage and Invasive Disease in High School Students in Georgia and Maryland, 2006-2007., PMID:33107578
Genetic incorporation of non-canonical amino acid photocrosslinkers in Neisseria meningitidis: New method provides insights into the physiological function of the function-unknown NMB1345 protein., PMID:32866169
Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage., PMID:32209693
Receptor recognition by meningococcal type IV pili relies on a specific complex N-glycan., PMID:31964828
Structure and function of minor pilins of type IV pili., PMID:31784891
Deep mutational scanning of the Neisseria meningitidis major pilin reveals the importance of pilus tip-mediated adhesion., PMID:31609039
Contribution of σ70 and σN Factors to Expression of Class II pilE in Neisseria meningitidis., PMID:31331980
Potentiation of Phase Variation in Multiple Outer-Membrane Proteins During Spread of the Hyperinvasive Neisseria meningitidis Serogroup W ST-11 Lineage., PMID:31119276
Inhibitors of the Neisseria meningitidis PilF ATPase provoke type IV pilus disassembly., PMID:30948644
Heteroresistance to the model antimicrobial peptide polymyxin B in the emerging Neisseria meningitidis lineage 11.2 urethritis clade: mutations in the pilMNOPQ operon., PMID:30338585
Analysis of Pilin Antigenic Variation in Neisseria meningitidis by Next-Generation Sequencing., PMID:30181126
Interactions between the Aggregatibacter actinomycetemcomitans secretin HofQ and host cytokines indicate a link between natural competence and interleukin-8 uptake., PMID:30088437
Intermittent Pili-Mediated Forces Fluidize Neisseria meningitidis Aggregates Promoting Vascular Colonization., PMID:29779947
Cryoelectron Microscopy Reconstructions of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV Pili at Sub-nanometer Resolution., PMID:28877506
Whole genome sequencing reveals within-host genetic changes in paired meningococcal carriage isolates from Ethiopia., PMID:28545446
Structural and genetic analyses of glycan O-acetylation in a bacterial protein glycosylation system: evidence for differential effects on glycan chain length., PMID:28460017
Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis., PMID:28431522
Host cell-derived lactate functions as an effector molecule in Neisseria meningitidis microcolony dispersal., PMID:28384279
Structure of the Neisseria meningitidis Type IV pilus., PMID:27698424
Positive Selection Pressure Drives Variation on the Surface-Exposed Variable Proteins of the Pathogenic Neisseria., PMID:27532335
A Comparative Structure/Function Analysis of Two Type IV Pilin DNA Receptors Defines a Novel Mode of DNA Binding., PMID:27161979
Neisseria cinerea isolates can adhere to human epithelial cells by type IV pilus-independent mechanisms., PMID:26813911
Characterization of a Unique Tetrasaccharide and Distinct Glycoproteome in the O-Linked Protein Glycosylation System of Neisseria elongata subsp. glycolytica., PMID:26483525
Neisseria meningitidis Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation., PMID:26367394
Structural and functional studies of the Pseudomonas aeruginosa minor pilin, PilE., PMID:26359492
The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation., PMID:26248334
Mobile DNA in the Pathogenic Neisseria., PMID:26104562
Antimicrobial peptide resistance in Neisseria meningitidis., PMID:26002321
Characterization of motility and piliation in pathogenic Neisseria., PMID:25925502
Characterization of a novel antisense RNA in the major pilin locus of Neisseria meningitidis influencing antigenic variation., PMID:25755192
Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis., PMID:25274119
Type IV pili-a numbers game., PMID:24966276
The number of Neisseria meningitidis type IV pili determines host cell interaction., PMID:24864127
Sequence, distribution and chromosomal context of class I and class II pilin genes of Neisseria meningitidis identified in whole genome sequences., PMID:24690385
The hypervariable region of meningococcal major pilin PilE controls the host cell response via antigenic variation., PMID:24520062
The use of high-throughput DNA sequencing in the investigation of antigenic variation: application to Neisseria species., PMID:24466206
For research use only. Not for human or drug use.
