Catalog No.
AHE21001
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Thr23-Asp159
Predicted molecular weight
42.6 kDa
Nature
Recombinant
Endotoxin level
< 1 EU/µg as determined by LAL test.
Purity
>90% as determined by SDS-PAGE.
Accession
P37173
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a 0.2 μm filtered solution in 20 mM PB, 150 mM NaCl, pH 7.4.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
TGFR-2, TbetaR-II, TGF-beta type II receptor, TGFBR2, TGF-beta receptor type-2, TGF-beta receptor type II, Transforming growth factor-beta receptor type II
Differences in Arterial Events in Vascular Ehlers-Danlos, Loeys-Dietz, and Marfan Syndrome., PMID:40533124
Characterization of Arterial Aneurysms in Loeys-Dietz Syndrome., PMID:40533122
Cytogenetic anomalies are the predominant genetic alteration in children with nonfamilial tall stature: a comparative study with familial cases., PMID:40524006
Update on the pathophysiology and treatment of diabetic kidney disease: a narrative review., PMID:40521811
MiR-106b-5p improving the progression of chronic kidney disease by inhibiting the TGF-β/Smad pathway., PMID:40514734
The RNA-binding protein TRIM71 is essential for hearing in humans and mice and regulates the timing of auditory sensory organ development., PMID:40501610
Defective Mitochondrial Respiration in Hereditary Thoracic Aneurysms., PMID:40497944
Genetic analysis and functional assessment of a TGFBR2 variant in micrognathia and cleft palate., PMID:40489498
Enhanced anti-tumor activity by zinc finger repressor-driven epigenetic silencing of immune checkpoints and TGFBR2 in CAR-T cells and TILs., PMID:40487483
The BAG3-HSP70-CHIP axis controls the degradation of TGFBR2 in cardiac fibroblasts., PMID:40482877
Transcriptomic Profiling of Hypoxia-Adaptive Responses in Tibetan Goat Fibroblasts., PMID:40427283
Autophagic degradation of SQSTM1 enables fibroblast activation to accelerate wound healing., PMID:40400126
Nintedanib regulates miR-23b-3p/TGFBR2 axis and competitively binds to TGFBR2 protein, inhibiting EMT process in human pterygium cells., PMID:40385123
Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3., PMID:40360531
Transforming growth factor-β1 and its soluble receptor type 2 in saliva of young adults: Sex-related differences and predictive modeling of salivary concentrations., PMID:40347849
MRI-based machine learning reveals proteasome subunit PSMB8-mediated malignant glioma phenotypes through activating TGFBR1/2-SMAD2/3 axis., PMID:40335825
Robust differentiation of NK cells from MSLN.CAR-IL-15-engineered human iPSCs with enhanced antitumor efficacy against solid tumors., PMID:40315330
Cytokines from parasites: manipulating host responses by molecular mimicry., PMID:40302223
Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival., PMID:40301302
TGFBR2 as a prognostic marker and therapeutic target in benzo(a)pyrene-associated esophageal cancer: insights from multi-omics analysis., PMID:40293202
Regulatory T Cell Mimicry by a Subset of Mesenchymal GBM Stem Cells Suppresses CD4 and CD8 Cells., PMID:40277917
In Silico-Designed TGFβRI/TGFβRII Receptor Complex Peptide Inhibitors Exhibit Biological Activity In Vitro., PMID:40245195
Analysis of FBN1, TGFβ2, TGFβR1 and TGFβR2 mRNA as Key Molecular Mechanisms in the Damage of Aortic Aneurysm and Dissection in Marfan Syndrome., PMID:40243722
ADAMTS18 deficiency leads to abnormal brain methylation metabolism, dysregulated neuroinflammatory response, and unsound blood-brain barrier structure in mice., PMID:40227359
Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease., PMID:40205047
Mediators of the causal associations between protein ratios and ischemic stroke: a two-step Mendelian randomization study., PMID:40181221
Lipotoxicity Induces β-cell Small Extracellular Vesicle-Mediated β-cell Dysfunction in Male Mice., PMID:40179251
Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis., PMID:40146935
Advance in candidate genes in mandibular retrognathism: A systematic review., PMID:40132276
Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis., PMID:40125634
Chemokine (C-C Motif) Ligand 2 Expressing Adventitial Fibroblast Expansion During Loeys-Dietz Syndrome Aortic Aneurysm Formation., PMID:40109260
Exploring polymorphisms in genes encoding growth factors associated with non-syndromic cleft lip with or without cleft palate and tooth agenesis., PMID:40105578
Gonadotropin-releasing hormone regulates transcription of the inhibin B co-receptor, TGFBR3L, via early growth response one., PMID:40090584
Identification of Systemic Drug Targets for Anti-cavernous Fibrosis in the Treatment of Erectile Dysfunction, Guided by Genome-Wide Mendelian Randomization., PMID:40077914
The Loss of HJV Aggravates Muscle Atrophy by Promoting the Activation of the TβRII/Smad3 Pathway., PMID:40076640
Natural antifibrosis potential of anthocyanin in Ipomoea batatas against Transforming Growth Factor beta Type II receptor by in silico ADMET and molecular docking study., PMID:40062189
The Complicated Genetics behind Uncomplicated Type B Aortic Dissection., PMID:40058456
Emerging Pathogenetic Mechanisms and New Drugs for Anemia in Myelofibrosis and Myelodysplastic Syndromes., PMID:40056069
Repair of Isoaspartyl Residues by PCMT1 and Kidney Fibrosis., PMID:40036072
Nuclear translocation of CDK5RAP3 regulated by NXF3 promotes the progression of gastric cancer., PMID:40032765
Development of CAR-T cell therapy for NF1/SWN-related nerve sheath tumor treatment., PMID:40025578
SFRP4 Knockdown Attenuates Dsg2-Deficient Arrhythmogenic Cardiomyopathy by Down-Regulating TGF-β and Smad3., PMID:40019607
Design of high-affinity binders to immune modulating receptors for cancer immunotherapy., PMID:40011465
Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling., PMID:40011426
Characterization and Anti-Inflammatory Effects of Akkermansia muciniphila-Derived Extracellular Vesicles., PMID:40005829
TRPC6-Mediated Zn2+ Influx Negatively Regulates Contractile Differentiation of Vascular Smooth Muscle Cells., PMID:40001570
Generation of frameshift-mutated TGFβR2-specific T cells in healthy subjects following administration with cancer vaccine candidate FMPV-1/GM-CSF in a phase 1 study., PMID:39998682
Modulation of TGF-β signaling new approaches toward kidney disease and fibrosis therapy., PMID:39990662
Deregulation of Exosomal miR-17, miR-20a and TGFBR2 in Head and Neck Cancer Patients., PMID:39989256
TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts., PMID:39984487
For research use only. Not for human or drug use.
