Catalog No.
AHC79001
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
IIe21-Tyr247
Predicted molecular weight
26.6 kDa
Nature
Recombinant
Endotoxin level
< 1 EU/µg as determined by LAL test.
Purity
>90% as determined by SDS-PAGE.
Accession
P10144
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Liquid
Storage buffer
Supplied as a 0.2 μm filtered solution in PBS, pH 7.4.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cathepsin G-like 1, Granzyme-2, GZMB, Fragmentin-2, Human lymphocyte protein, HLP, CTLA-1, CGL1, CTSGL1, CSPB, Lymphocyte protease, T-cell serine protease 1-3E, Granzyme B, CTLA1, GRB, C11, Cytotoxic T-lymphocyte proteinase 2, SECT
Single-cell sequencing reveals cellular differences and potential mechanisms in congenital pulmonary airway malformation., PMID:40529122
The Aspergillus nidulans velvet domain containing transcription factor VeA is shuttled from cytoplasm into nucleus during vegetative growth and stays there for sexual development, but has to return into cytoplasm for asexual development., PMID:40523015
Notable influences of estrogen and sex-specific microenvironment in colorectal cancer revealed by single-cell transcriptome analysis., PMID:40520886
IL-15 functionalized biomimetic hybrid mRNA vaccine for enhanced NSCLC immunotherapy via synergistic activation of T cells and NK cells., PMID:40520563
SLC4A10 impedes atherosclerosis by diminishing IFN-γ/GZMB levels of CD8+ T cells via the MAPK pathway., PMID:40510365
Immune profiling of kidney transplant recipients: the role of Tribbles-1, Perforin, and Granzyme B in chronic humoral rejection., PMID:40488991
The functionality of telomerase depends on CPF-CF induced 3'end processing of its RNA component TLC1 and a novel Nrd1-Nab3 surveillance mechanism., PMID:40488281
In vivo proximity-labeling with miniTurboID to screen for protein-protein interactions in the filamentous ascomycete Sordaria macrospora., PMID:40488163
Glutamate transporter SLC1A6 promotes resistance to immunotherapy in cancer., PMID:40481876
Impact of immune checkpoint TIGIT on the activation and function of natural killer cells in rheumatoid arthritis patients., PMID:40465407
Evidence from a Comprehensive Bioinformatics Analysis Point to Possible Therapeutic Targets for Vitiligo., PMID:40452777
The Impact of Human Milk Oligosaccharides on Antibiotic-Induced Microbial Dysbiosis and Gut Inflammation in Mice., PMID:40426555
Myricetin-bound crystal structure of the SARS-CoV-2 helicase NSP13 facilitates the discovery of novel natural inhibitors., PMID:40421686
[Zfp335 regulates the proportion of effector Treg and tumor immunity]., PMID:40415616
CXCL8 and GZMB genes promote cartilaginous and synovial lesion formation via NF-κB and MAPK signaling pathways in Kaschin-Beck disease., PMID:40414318
Identification of Natural Killer Cell-Related Genes as Potential Diagnostic Biomarkers for Pediatric Sepsis., PMID:40411297
Small Extracellular Vesicle (sEV) Uptake from Lung Adenocarcinoma and Squamous Cell Carcinoma Alters T-Cell Cytokine Expression and Modulates Protein Profiles in sEV Biogenesis., PMID:40407494
Meta-analysis for alterations of IFN-γ, TNF-α and granzyme B levels in vitiligo patients., PMID:40402162
IFT20 regulates TFEB-dependent lytic granule biogenesis in cytotoxic T lymphocytes by orchestrating the MPR-dependent transport of granzyme B., PMID:40389449
Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation., PMID:40389394
Inhibition of UCH-L1 enhances immunotherapy efficacy in triple-negative breast cancer by stabilizing PD-L1., PMID:40389130
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B., PMID:40381623
Antioxidant interventions reduced cytokine-induced pyroptosis of peripheral MAIT cells in patients with HBV-related cirrhosis., PMID:40377492
The Human Bone Marrow May Offer an IL-15-Dependent Survival Niche for EOMES+ Tr1-Like Cells., PMID:40375822
Characterization of Two Stable Biodosimeters for Absorbed Ionizing Radiation Dose Estimation in Multiple Combined Injury Models., PMID:40360172
Rational development of gemcitabine-based nanoplatform for targeting SERPINB9/Granzyme B axis to overcome chemo-immune-resistance., PMID:40325025
Sonrotoclax (BGB-11417) synergistically amplifies the radiotherapy-elicited anti-tumor immune response., PMID:40311913
Novel diagnostic biomarker and immune profiling of GPR56+ B cell subsets in systemic lupus erythematosus., PMID:40311320
Identification and regulation of circulating tumor-TCR-matched cytotoxic CD4+ lymphocytes by KLRG1 in bladder cancer., PMID:40299576
Identification of INOSITOL PHOSPHORYLCERAMIDE SYNTHASE 2 (IPCS2) as a new rate-limiting component in Arabidopsis pathogen entry control., PMID:40298354
Smad4 loss identifies aggressive subtype with immunotherapy and anti-HER-2 treatment resistance in gastric cancer., PMID:40281303
GPX2 inhibition enhances antitumor efficacy of lenvatinib via promoting immunogenic cell death in hepatocellular carcinoma., PMID:40251668
Parabacteroides distasonis promotes CXCL9 secretion of tumor-associated macrophages and enhances CD8+T cell activity to trigger anti-tumor immunity against anti-PD-1 treatment in non-small cell lung cancer mice., PMID:40241108
Combination radiation and αPD-L1 enhance tumor control by stimulating CD8+ PD-1+ TCF-1+ T cells in the tumor-draining lymph node., PMID:40229241
Single cell transcriptome sequencing indicates the cellular heterogeneity of small intestine tissue in celiac disease., PMID:40216823
Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects., PMID:40216443
Identification of Salivary Biomarkers in Colorectal Cancer by Integrating Olink Proteomics and Metabolomics., PMID:40183281
Huaier enhances the antitumor effects of CDK 4/6 inhibitor by remodeling the immune microenvironment and gut microbiota in breast cancer., PMID:40179997
Reciprocal roles of two trehalose transporters in aestivating cabbage stem flea beetle (Psylliodes chrysocephala)., PMID:40174677
Attenuated Salmonella carrying IL-21 overexpression plasmid enhances radiotherapy efficacy in a preclinical model of melanoma., PMID:40174337
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses., PMID:40169810
Targeting PD-1 and CD85j can restore intratumoral CD4+ GzmB+ T-cell functions to combat MHC-II-expressing tumors., PMID:40169283
Single cell multi-omics reveals re-dosing with CD3 bispecific antibody induces a TCF7 high central memory CD8 + T cell population associated with reduced cytokine production., PMID:40168725
Association of the characteristics of brain magnetic resonance imaging with genes related to disease onset in schizophrenia patients., PMID:40158807
Patient-specific mutation of contact site protein Tomm70 causes neurodegeneration., PMID:40151845
Microbiota-reprogrammed phosphatidylcholine inactivates cytotoxic CD8 T cells through UFMylation via exosomal SerpinB9 in multiple myeloma., PMID:40128181
Hafnium Metal-Organic Framework-Based Glutamine Metabolism Disruptor For Potentiating Radio-Immunotherapy in MYC-Amplified Hepatocellular Carcinoma., PMID:40116395
Microwave ablation combined with α-PD-L1 enhances abscopal effect and promotes CTL activation and intratumoral homing by a cytokine network involving IFN-γ and CXCL9., PMID:40101420
Granzyme B producing regulatory B-cells in patients with giant cell arteritis., PMID:40095634
Arabidopsis GH3.10 conjugates jasmonates., PMID:40095511
For research use only. Not for human or drug use.
