Catalog No.
AHA08601
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Glu22-Leu401
Predicted molecular weight
44.65 kDa
Nature
Recombinant
Endotoxin level
< 1 EU/µg as determined by LAL test.
Purity
>90% as determined by SDS-PAGE.
Accession
O00300
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a 0.2 μm filtered solution in 20 mM PB, 150 mM NaCl, pH 7.4.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
OPG, Osteoclastogenesis inhibitory factor, Osteoprotegerin, TNFRSF11B, Tumor necrosis factor receptor superfamily member 11B, OCIF
MiR-217 participates in the progression of postmenopausal osteoporosis by regulating the OPG/RANKL/RANK pathway., PMID:40533787
Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation., PMID:40493738
The interaction of HT-2 toxin and Akt1 on gene expression regulation in Kashin-Beck disease pathogenesis., PMID:40449756
TNFRSF11B-modified umbilical cord mesenchymal stem cells as a novel strategy for bone-related diseases by suppressing osteoclast activity., PMID:40380204
Pamidronate regulates the osteogenic differentiation of periosteal-derived mesenchymal stem cells in congenital tibial pseudarthrosis via OPG/RANKL., PMID:40318381
Exploring inflammation-related protein expression and its relationship with TSPO PET in Alzheimer's disease., PMID:40289873
Epimedin B protects against bone loss and inflammation in diabetic osteoporosis rats by regulating OPG/RANKL pathway., PMID:40264188
Long-Term Denosumab Treatment in Adults with Juvenile Paget Disease., PMID:40223037
The Expression Profile of the RANK/RANKL/OPG Pathway in Breast Cancer Stem Cells Isolated From Breast Cancer Cell Lines., PMID:40159409
Nephrectomy Induces Severe Bone Loss in Mice Expressing Constitutively Active TGFβ Receptor Type I., PMID:40141345
Effects of photobiomodulation therapy with 808 nm diode laser on the expression of RANKL and OPG genes in exosomes isolated from MG63 osteoblast-like cells: An in-vitro study., PMID:40122481
Anti-Osteoporosis and Bone Protective Effects of Resveratrol in Rats With Chronic Kidney Disease-Induced Osteoporosis., PMID:40045654
Osteoprotegerin is induced by transforming growth factor-beta 1 and regulates pro-fibrotic responses in human dermal fibroblasts., PMID:40031101
Novel biomarkers in bone pathophysiology: Establishing reference intervals and biological variations estimates for serum leptin, sclerostin, lipocalin-2, osteoprotegerin, resistin and Dickkopf-related protein-1 from the European biological variation study (EuBIVAS) populations., PMID:40010661
Chronically increased osteoclastogenesis in adult celiac disease patients does not hinder improvement in bone health induced by gluten-free diet: Role of vitamin D, OPG and IL-6., PMID:39978647
The Role of Osteoprotegerin in Breast Cancer: Genetic Variations, Tumorigenic Pathways, and Therapeutic Potential., PMID:39941709
Periostin Splice Variant Expression in Human Osteoblasts from Osteoporotic Patients and Its Effects on Interleukin-6 and Osteoprotegerin., PMID:39940700
Paracrine Influence of Masquelet's Induced Membrane on Marrow Derived Mesenchymal Stem Cells., PMID:39921504
Plasma Osteoprotegerin and Cognitive Impairment after Ischemic Stroke., PMID:39886782
Effects of Fisetin and Nicorandil on adjuvant-induced rheumatoid arthritis in rats: Emerging role of TLR4/NF-κB-induced Pyroptosis, Nrf-2/HO-1, and OPG/RANKL pathways., PMID:39884184
Antiosteoporosis and Bone Protective Effect of Phyllanthin Against Glucocorticoid-induced Osteoporosis in Rats via Alteration of HO-1/Nrf2 and RANK/RANKL/OPG Pathway., PMID:39849266
Alternating Aerobics with Resistance Exercise Improves Bone Density and Circulating Irisin Levels in Postmenopausal Women., PMID:39787500
Investigation of Oxidative-Stress Impact on Human Osteoblasts During Orthodontic Tooth Movement Using an In Vitro Tension Model., PMID:39769290
ATRX silences Cartpt expression in osteoblastic cells during skeletal development., PMID:39744954
Sclerostin and OPG/RANK-L system take part in bone remodeling in patients with acromegaly., PMID:39741885
Long non-coding RNA Malat1 fine-tunes bone homeostasis and repair by orchestrating cellular crosstalk and β-catenin-OPG/Jagged1 pathway., PMID:39714456
Causal effects of the RANK-RANKL-OPG system and scoliosis: A bidirectional 2-sample Mendelian randomization study., PMID:39686424
Are the Soluble Receptors sRAGE, sRANKL, and Osteoprotegerin Associated with Anemia in Rheumatoid Arthritis?, PMID:39684440
Genes involved in osteogenic differentiation induced by low‑intensity pulsed ultrasound in goldfish scales., PMID:39651404
The association between osteoprotegerin and arterial stiffness in a 10-year longitudinal study of patients with type 2 diabetes., PMID:39626773
Biological Markers in the Gingival Crevicular Fluid Associated with External Invasive Resorption: A Split-Mouth Cross-Sectional Study., PMID:39617293
Distinct Patterns of Smooth Muscle Phenotypic Modulation in Thoracic and Abdominal Aortic Aneurysms., PMID:39590192
Effects of COVID-19 on bone fragility: a new perspective from osteoimmunological biomarkers., PMID:39582872
Selective Pyk2 inhibition enhances bone restoration through SCARA5-mediated bone marrow remodeling in ovariectomized mice., PMID:39578816
The Effect of Osteoprotegerin (OPG)/Receptor Activator of Nuclear Factor-κB Ligand (RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) on Aortic Valve Calcified., PMID:39537225
Investigating the Biological Efficacy of Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF): A Study on Cytokine Dynamics and Osteoblast Behavior., PMID:39519084
The effect of cold atmospheric plasma on viability of osteoblasts and expression of RANKL and OPG genes in medium with bisphosphonates., PMID:39506017
Correlation of metabolic markers and OPG gene mutations with bone mass abnormalities in postmenopausal women., PMID:39487469
TNFRSF11B promotes the progression of bladder cancer through PI3K/AKT signaling pathway., PMID:39481664
STUDY THE RELATIONSHIP BETWEEN OSTEOPROTEGERIN AND KIDNEY INJURY MOLECULE-1 AND SOME BIOCHEMICAL VARIABLES IN PATIENTS WITH KIDNEY STONES., PMID:39441273
The PANoptosis-related hippocampal molecular subtypes and key biomarkers in Alzheimer's disease patients., PMID:39394418
Interactions of the Osteokines, Glucose/Insulin System and Vascular Risk Networks in Patients With Newly Diagnosed Type 2 Diabetes (VNDS 15)., PMID:39393014
Analysis of angiotensin II type 1 receptor and osteoprotegerin gene polymorphism on the risk of cardiovascular mortality risk and progressivity of chronic kidney disease., PMID:39376100
Vertebral marrow fat fraction is associated with circulating RANKL in postmenopausal females., PMID:39351524
Vascular Cytokines and Atherosclerosis: Differential Serum Levels of TRAIL, IL-18, and OPG in Obstructive Coronary Artery Disease., PMID:39334884
Serum proinflammatory cytokines, receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG) and RANKL/OPG ratio in mild and severe COVID-19., PMID:39333916
Cardenolides; calotropin and gomphogenin from Calotropis procera (Aiton) mitigate bone turnover in ovariectomized osteoporotic rats: Targeting RANKL/OPG axis and estrogen receptor-alpha., PMID:39321857
Integrated bioinformatic analysis of protein landscape in gingival crevicular fluid unveils sequential bioprocess in orthodontic tooth movement., PMID:39307846
Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells., PMID:39289624
RANK-RANKL-OPG Axis in MASLD: Current Evidence Linking Bone and Liver Diseases and Future Perspectives., PMID:39273141
For research use only. Not for human or drug use.
