Catalog No.
DHJ04003
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Humanized
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
CD276, B7-H3, Costimulatory molecule, B7H3, 4Ig-B7-H3, B7 homolog 3, CD276 antigen
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q5ZPR3
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
ABBV-155, CAS: 2229859-11-2
Clone ID
Mirzotamab
Evaluation of the role of B7-H3 haplotype in association with impaired B7-H3 expression and protection against type 1 diabetes in Chinese Han population. PMID: 32787907
Associations of B7-H3 and B7-H4 Expression in Ductal Carcinoma In Situ of the Breast With Clinicopathologic Features and T-Cell Infiltration. PMID: 31714284
Effects of liver-targeted drugs on expression of immune-related proteins in hepatocellular carcinoma cells. PMID: 29940148
Comprehensive analysis of angiogenesis subtype of squamous cell carcinoma. PMID: 34521431
Retinal Pigment Epithelial Cells Derived from Induced Pluripotent Stem (iPS) Cells Suppress or Activate T Cells via Costimulatory Signals. PMID: 32899567
The contrasting role of B7-H3. PMID: 18650376
Identification of inhibitory immune checkpoints and relevant regulatory pathways in breast cancer stem cells. PMID: 33932112
Advances in immunotherapeutic targets for childhood cancers: A focus on glypican-2 and B7-H3. PMID: 33992682
Cytoplasmic expression of B7-H3 and membranous EpCAM expression are associated with higher grade and survival outcomes in patients with clear cell renal cell carcinoma. PMID: 32143173
Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children's Oncology Group. PMID: 32703985
A membrane protein display platform for receptor interactome discovery. PMID: 34531301
CXCR2 specific endocytosis of immunomodulatory peptide LL-37 in human monocytes and formation of LL-37 positive large vesicles in differentiated monoosteophils. PMID: 31886324
Cloning and characterization of porcine 4Ig-B7-H3: a potent inhibitor of porcine T-cell activation. PMID: 21738638
B7‑H3 promotes malignant progression of muscle‑invasive bladder cancer. PMID: 30132557
Comprehensive analysis of a 14 immune-related gene pair signature to predict the prognosis and immune features of gastric cancer. PMID: 33049494
B7-H3 protein expression in acute myeloid leukemia. PMID: 26376842
The role of miR-29c/B7-H3/Th17 axis in children with Mycoplasma pneumoniae pneumonia. PMID: 31088519
Breast Cancer Detection by B7-H3-Targeted Ultrasound Molecular Imaging. PMID: 25899053
Central nervous system neuroblastoma metastases pseudoprogression following intraventricular anti-B7-H3 radioimmunotherapy. PMID: 31313059
B7-H3 Induces Ovarian Cancer Drugs Resistance Through An PI3K/AKT/BCL-2 Signaling Pathway. PMID: 31819652
PD-L1, B7-H3 and VISTA are highly expressed in gestational trophoblastic neoplasia. PMID: 31013360
The right place at the right time: novel B7 family members regulate effector T cell responses. PMID: 11973139
The role of miR-29c/B7-H3 axis in children with allergic asthma. PMID: 30075787
B7-H3 is related to tumor progression in ovarian cancer. PMID: 28765941
hsa_circ0021347 as a Potential Target Regulated by B7-H3 in Modulating the Malignant Characteristics of Osteosarcoma. PMID: 31950059
B7H3 regulates differentiation and serves as a potential biomarker and theranostic target for human glioblastoma. PMID: 30914782
Affibody-Indocyanine Green Based Contrast Agent for Photoacoustic and Fluorescence Molecular Imaging of B7-H3 Expression in Breast Cancer. PMID: 31082216
Integrative Characterization of Immune-relevant Genes in Hepatocellular Carcinoma. PMID: 34221916
B7-H3-targeted 212Pb radioimmunotherapy of ovarian cancer in preclinical models. PMID: 28104527
Development of a Four-mRNA Expression-Based Prognostic Signature for Cutaneous Melanoma. PMID: 34335689
B7-H3 increases the radioresistance of gastric cancer cells through regulating baseline levels of cell autophagy. PMID: 31396347
B7-H3 is regulated by BRD4 and promotes TLR4 expression in pancreatic ductal adenocarcinoma. PMID: 30664982
B7-H3 promoted sperm motility in humans. PMID: 24246324
SCLC-J1, a novel small cell lung cancer cell line. PMID: 34381882
Reduced serum B7-H3 levels in patients with ankylosing spondylitis. PMID: 25567370
Relationship Between Serum B7-H3 Levels and Prognosis of Congenital Heart Disease in Children. PMID: 30328478
MicroRNA-506 inhibits the proliferation and invasion of mantle cell lymphoma cells by targeting B7H3. PMID: 30553455
Targeting immunotherapy for bladder cancer using anti-CD3× B7-H3 bispecific antibody. PMID: 30253078
[The expression and significance of CD(276) and CD(133) in colorectal cancer and precancerous lesions]. PMID: 29925132
B7-H3 expression in children with asthma exacerbation. PMID: 26108069
Murine b7-h3 is a co-stimulatory molecule for T cell activation. PMID: 24328742
[Expression of costimulatory molecules B7H3 and B7H4 in T lymphoblastic lymphoma/leukemia and clinical significance]. PMID: 31104673
B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway. PMID: 26787540
Immunoregulatory protein B7-H3 promotes growth and decreases sensitivity to therapy in metastatic melanoma cells. PMID: 28513992
PD-1 related transcriptome profile and clinical outcome in diffuse gliomas. PMID: 29308304
Plasma soluble B7-H3 levels for severity evaluation in pediatric patients with Mycoplasma pneumoniae pneumonia. PMID: 31100711
B7-H3 participates in human salivary gland epithelial cells apoptosis through NF-κB pathway in primary Sjögren's syndrome. PMID: 31412888
Soluble B7-H3 (sB7-H3) is over-expressed in the serum of type 1 diabetes patients. PMID: 30081105
High constitutive B7-H3 expression on human keratinocytes supports T cell immunity. PMID: 28465042
Molecular imaging of T cell co-regulator factor B7-H3 with 89Zr-DS-5573a. PMID: 30128047
Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation. PMID: 30082909
Tumor B7-H3 expression in diagnostic biopsy specimens and survival in patients with metastatic prostate cancer. PMID: 33558663
BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors., PMID:39365864
For research use only. Not for human or drug use.
