Catalog No.
DHJ04002
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Mouse
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
CD276, B7-H3, Costimulatory molecule, B7H3, 4Ig-B7-H3, B7 homolog 3, CD276 antigen
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q5ZPR3
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
8H9, Mab 8H9, CAS: 1895083-75-6
Clone ID
Omburtamab
Antibodies to watch in 2020, PMID: 31847708
B7H3-Directed Intraperitoneal Radioimmunotherapy With Radioiodinated Omburtamab for Desmoplastic Small Round Cell Tumor and Other Peritoneal Tumors: Results of a Phase I Study, PMID: 33119478
Antibodies to watch in 2019, PMID: 30516432
Future of Theranostics: An Outlook on Precision Oncology in Nuclear Medicine, PMID: 31481583
IntraOmmaya compartmental radioimmunotherapy using 131 I-omburtamab-pharmacokinetic modeling to optimize therapeutic index, PMID: 33047248
Biodistribution and Dosimetry of Intraventricularly Administered 124 I-Omburtamab in Patients with Metastatic Leptomeningeal Tumors, PMID: 31405921
Targeted radioimmunotherapy for embryonal tumor with multilayered rosettes, PMID: 30879172
Repeat convection-enhanced delivery for diffuse intrinsic pontine glioma, PMID: 32977309
Mast cell proliferation in the cerebrospinal fluid after intraventricular administration of anti-B7H3 immunotherapy, PMID: 33533945
Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes, PMID: 33514401
Evaluation of a patient-specific algorithm for predicting distribution for convection-enhanced drug delivery into the brainstem of patients with diffuse intrinsic pontine glioma, PMID: 33990084
Identification of targets for prostate cancer immunotherapy. PMID: 30614027
B7-h3 and its role in antitumor immunity. PMID: 21127709
Tracers for non-invasive radionuclide imaging of immune checkpoint expression in cancer. PMID: 31696402
Multiple Immune-Suppressive Mechanisms in Fibrolamellar Carcinoma. PMID: 30902819
T cell coinhibition and immunotherapy in human breast cancer. PMID: 23114578
Downregulated miR-187 contributes to the keratinocytes hyperproliferation in psoriasis. PMID: 30607907
MMP2 as an independent prognostic stratifier in oral cavity cancers. PMID: 32934875
Wharton's Jelly Mesenchymal Stromal Cells from Human Umbilical Cord: a Close-up on Immunomodulatory Molecules Featured In Situ and In Vitro. PMID: 31741193
Profiling targetable immune checkpoints in osteosarcoma. PMID: 30524885
Immune regulation by novel costimulatory molecules. PMID: 12947223
Route of 41BB/41BBL Costimulation Determines Effector Function of B7-H3-CAR.CD28ζ T Cells. PMID: 32728609
High B7-H3 expression is linked to increased risk of prostate cancer progression. PMID: 32776718
Tumor cell-associated immune checkpoint molecules - Drivers of malignancy and stemness. PMID: 29056539
Evaluation of ductal carcinoma in situ grade via triple-modal molecular imaging of B7-H3 expression. PMID: 32377564
B7-H3 and its relevance in cancer; immunological and non-immunological perspectives. PMID: 21622107
B7-H3 immune checkpoint expression is a poor prognostic factor in colorectal carcinoma. PMID: 32514163
B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer. PMID: 33011740
Knocking down B7H3 expression enhances cell proliferation of SHEDs via the SHP1/AKT signal axis. PMID: 32800541
B7-H3 as a Prognostic Biomarker and Therapeutic Target in Pediatric central nervous system Tumors. PMID: 31887631
Immune Landscape of the B7 and TNFR Families in Oral Squamous Cell Carcinoma. PMID: 32548602
Antibody-Prodrug Conjugates with KSP Inhibitors and Legumain-Mediated Metabolite Formation. PMID: 30869180
PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. PMID: 18662368
Development of Autophagy Signature-Based Prognostic Nomogram for Refined Glioma Survival Prognostication. PMID: 32964017
Fine tuning the immune response through B7-H3 and B7-H4. PMID: 19426220
Serum soluble B7-H3 is a prognostic marker for patients with non-muscle-invasive bladder cancer. PMID: 33306717
Efficacy of Affibody-Based Ultrasound Molecular Imaging of Vascular B7-H3 for Breast Cancer Detection. PMID: 31924738
The role of costimulatory molecules in allergic disease and asthma. PMID: 19786798
Combination therapy with B7H3-redirected bispecific antibody and Sorafenib elicits enhanced synergistic antitumor efficacy. PMID: 32929362
B7-H3 modulates endothelial cell angiogenesis through the VEGF cytokine. PMID: 31292886
Expression and Significance of Immune Checkpoints in Clear Cell Carcinoma of the Uterine Cervix. PMID: 32322590
Changes and Significance of Serum sB7-H3 and Cytokines in Children with Mycoplasma pneumonae Pneumonia. PMID: 32169134
B7-H3 is spliced by SRSF3 in colorectal cancer. PMID: 32719950
sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings. PMID: 32953890
B7-H3 expression in upper tract urothelial carcinoma associates with adverse clinicopathological features and poor survival. PMID: 33049447
Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer. PMID: 27835582
Identification of immunological subtypes of hepatocellular carcinoma with expression profiling of immune-modulating genes. PMID: 32544882
p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance. PMID: 30967582
Blocking PD-1/PD-L1 by an ADCC enhanced anti-B7-H3/PD-1 fusion protein engages immune activation and cytotoxicity. PMID: 32422527
Modulation of costimulation to enhance tumor immunity. PMID: 12920481
A review of B7-H3 and B7-H4 immune molecules and their role in ovarian cancer. PMID: 22910694
High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma. PMID: 31249064
Yin-Yang of costimulation: crucial controls of immune tolerance and function. PMID: 19426216
B7-H3-Induced Signaling in Lung Adenocarcinoma Cell Lines with Divergent Epidermal Growth Factor Receptor Mutation Patterns. PMID: 33426073
Systematic analysis of the transcriptome in small-cell carcinoma of the oesophagus reveals its immune microenvironment. PMID: 33033616
Coinhibitory T-cell signaling in islet allograft rejection and tolerance. PMID: 16719045
The expression and clinical significance of B7-H3 and miR-145 in lung cancer patients with malignant pleural effusion. PMID: 32633367
The interaction of MMP-2/B7-H3 in human osteoporosis. PMID: 26631755
B7-H3 and B7-H4 Expression in Breast Cancer and Their Association with Clinicopathological Variables and T Cell Infiltration. PMID: 32088722
B7-H3 promotes gastric cancer cell migration and invasion. PMID: 29069741
Hormonal Regulation of Dendritic Cell Differentiation in the Thymus. PMID: 29922998
For research use only. Not for human or drug use.
