Catalog No.
YHC93001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe317
Predicted molecular weight
38.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P12271
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Retinaldehyde-binding protein 1, CRALBP, Cellular retinaldehyde-binding protein, RLBP1
Id2 transcriptional repressor promotes retinal Müller glial cell fate choice by increasing Notch activity., PMID:40398096
Genetic mutation in HSF4 is associated with retinal degeneration in mice., PMID:40023307
Patient-Reported Outcomes in RLBP1 Retinal Dystrophy: Longitudinal Assessment in a Prospective Natural History Study., PMID:39541109
Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle., PMID:39448563
Dual CRALBP isoforms unveiled: iPSC-derived retinal modeling and AAV2/5-RLBP1 gene transfer raise considerations for effective therapy., PMID:39385467
Interim safety and efficacy of gene therapy for RLBP1-associated retinal dystrophy: a phase 1/2 trial., PMID:39256350
RDH5 and RLBP1-Associated Inherited Retinal Diseases: Refining the Spectrum of Stationary and Progressive Phenotypes., PMID:38945349
A NOVEL RLBP1 GENE MUTATION ASSOCIATED WITH RETINAL FLECKS., PMID:38470931
The Rax homeoprotein in Müller glial cells is required for homeostasis maintenance of the postnatal mouse retina., PMID:37977220
Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery., PMID:37191732
Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery., PMID:36993571
Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death., PMID:35758026
Impact of Next Generation Sequencing in Unraveling the Genetics of 1036 Spanish Families With Inherited Macular Dystrophies., PMID:35119454
The rhodopsin-retinochrome system for retinal re-isomerization predates the origin of cephalopod eyes., PMID:34844573
Advantages of nanofibrous membranes for culturing of primary RPE cells compared to commercial scaffolds., PMID:34687141
Disturbed retinoid metabolism upon loss of rlbp1a impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retina., PMID:34668483
The TGFβ/Notch axis facilitates Müller cell-to-epithelial transition to ultimately form a chronic glial scar., PMID:34593012
Variants of Uncertain Significance: Twins With Identical Pathogenic Gene Mutations in Retinitis Punctata Albescens., PMID:34410188
Retinitis Punctata Albescens and RLBP1-Allied Phenotypes: Phenotype-Genotype Correlation and Natural History in the Aim of Gene Therapy., PMID:36247817
Shared Features in Retinal Disorders With Involvement of Retinal Pigment Epithelium., PMID:34115091
Molecular genetics of inherited retinal degenerations in Icelandic patients., PMID:33851411
Impairments of Photoreceptor Outer Segments Renewal and Phototransduction Due to a Peripherin Rare Haplotype Variant: Insights from Molecular Modeling., PMID:33801777
Pathogenesis Study Based on High-Throughput Single-Cell Sequencing Analysis Reveals Novel Transcriptional Landscape and Heterogeneity of Retinal Cells in Type 2 Diabetic Mice., PMID:33674409
Function of mammalian M-cones depends on the level of CRALBP in Müller cells., PMID:33216847
The genetics of rod-cone dystrophy in Arab countries: a systematic review., PMID:33188265
Prolonged Melanopsin-based Photoresponses Depend in Part on RPE65 and Cellular Retinaldehyde-binding Protein (CRALBP)., PMID:32841098
A multimodal study and management of retinitis punctata albescens., PMID:32685789
Clinical heterogeneity in retinitis pigmentosa caused by variants in RP1 and RLBP1 in five extended consanguineous pedigrees., PMID:32587456
A novel homozygous frameshift variant in the cellular retinaldehyde-binding protein 1 (RLBP1) gene causes retinitis punctata albescens., PMID:32345050
Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration., PMID:32277175
Effects of deficiency in the RLBP1-encoded visual cycle protein CRALBP on visual dysfunction in humans and mice., PMID:32188692
RALBP1 regulates oral cancer cells via Akt and is a novel target of miR-148a-3p and miR-148b-3p., PMID:31336396
Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration., PMID:30742112
Effects of trans-resveratrol on type 1 diabetes-induced inhibition of retinoic acid metabolism pathway in retinal pigment epithelium of Dark Agouti rats., PMID:30030988
Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci., PMID:29529059
Nonclinical Safety Evaluation of scAAV8-RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa., PMID:29359172
AβPP-induced UPR Transcriptomic Signature of Glial Cells to Oxidative Stress as an Adaptive Mechanism to Preserve Cell Function and Survival., PMID:29357794
A NOVEL LARGE HOMOZYGOUS DELETION IN THE CELLULAR RETINALDEHYDE-BINDING PROTEIN GENE (RLBP1) IN A PATIENT WITH RETINITIS PUNCTATA ALBESCENS., PMID:28827498
Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1., PMID:28813576
A novel RLBP1 gene geographical area-related mutation present in a young patient with retinitis punctata albescens., PMID:28764803
Epithelial-mesenchymal transition of the retinal pigment epithelium causes choriocapillaris atrophy., PMID:27372654
Molecular studies of phenotype variation in canine RPGR-XLPRA1., PMID:27122963
Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium., PMID:26876013
Enriched Cultures of Retinal Cells From BJNhem20 Human Embryonic Stem Cell Line of Indian Origin., PMID:26567782
AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice., PMID:26199951
CRALBP supports the mammalian retinal visual cycle and cone vision., PMID:25607845
A transient wave of BMP signaling in the retina is necessary for Müller glial differentiation., PMID:25605781
Comparative transcriptomic analysis provides insights into the molecular basis of the metamorphosis and nutrition metabolism change from zoeae to megalopae in Eriocheir sinensis., PMID:25460100
Phenotype variations of retinal dystrophies caused by mutations in the RLBP1 gene., PMID:25429852
For research use only. Not for human or drug use.
