Catalog No.
YHC92801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp226-Phe514
Predicted molecular weight
33.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P12268
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IMPDH-II, IMPD 2, IMPD2, IMPDH2, IMPDH 2, Inosine-5'-monophosphate dehydrogenase 2, IMP dehydrogenase 2
Epstein-Barr virus latent membrane protein 1 subverts IMPDH pathways to drive B-cell oncometabolism., PMID:40367275
Domain-specific AI segmentation of IMPDH2 rod/ring structures in mouse embryonic stem cells., PMID:40350411
Regulation and function of inosine monophosphate dehydrogenase 2 cytoophidia during mouse and human decidualization., PMID:40209967
USP5 deubiquitinates and stabilizes IMPDH2, to promote hepatocellular carcinoma progression., PMID:40164869
Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition., PMID:40102405
Design and Synthesis of Mycophenolic Acid Analogues for Osteosarcoma Cancer Treatment., PMID:39990949
Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer., PMID:39774345
IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth., PMID:39739531
Epstein-Barr Virus Latent Membrane Protein 1 Subverts IMPDH pathways to drive B-cell oncometabolism., PMID:39574729
Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma., PMID:39567689
Nuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity., PMID:39532854
IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation., PMID:39470689
Impaired inosine monophosphate dehydrogenase leads to plant-specific ribosomal stress responses in Arabidopsis thaliana., PMID:39235732
Investigating the mechanism of ferroptosis induction by sappanone A in hepatocellular carcinoma: NRF2/xCT/GPX4 axis., PMID:39214275
Integrative Proteomics-Metabolomics of In Vitro Degeneration of Cardiovascular Cell Lines., PMID:39110328
IMPDH2 suppression impedes cell proliferation by instigating cell cycle arrest and stimulates apoptosis in pediatric hepatoblastoma., PMID:39085725
IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency., PMID:39075237
Exploring the Antiangiogenic and Anti-Inflammatory Potential of Homoisoflavonoids: Target Identification Using Biotin Probes., PMID:39062499
Vitexicarpin suppresses malignant progression of colorectal cancer through affecting c-Myc ubiquitination by targeting IMPDH2., PMID:39008915
Influence of genetic polymorphisms on pharmacokinetics and treatment response of mycophenolic acid: a scoping review., PMID:38884938
Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy., PMID:38871858
Inosine monophosphate dehydrogenase type 2 polymorphism IMPDH2 3757T>C (rs11706052) and 12-month evolution of the graft function in renal transplant recipients on mycophenolate-based immunosuppression., PMID:38769303
IMPDH2 Positively Impacts the Proliferation Potential of Hepatoblastoma Cells by Activating JunB Signaling Pathway., PMID:38676510
Discovery of a Tunable Heterocyclic Electrophile 4-Chloro-pyrazolopyridine That Defines a Unique Subset of Ligandable Cysteines., PMID:38629450
Ganodermanontriol Suppresses the Progression of Lung Adenocarcinoma by Activating CES2 to Enhance the Metabolism of Mycophenolate Mofetil., PMID:38419324
Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer., PMID:38310229
Longitudinal plasma proteome profiling reveals the diversity of biomarkers for diagnosis and cetuximab therapy response of colorectal cancer., PMID:38302471
IMPDH2 forms spots at branching sites and distal ends of astrocyte stem processes., PMID:38009721
Molecular Mechanisms for Changing Brain Connectivity in Mice and Humans., PMID:37958822
Single-cell RNA sequencing in double-hit lymphoma: IMPDH2 induces the progression of lymphoma by activating the PI3K/AKT/mTOR signaling pathway., PMID:37907047
Combining multi-omics analysis to identify host-targeted targets for the control of Brucella infection., PMID:37882474
Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer., PMID:37871880
Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway., PMID:37752569
Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation., PMID:37414152
Growth Transformation of B Cells by Epstein-Barr Virus Requires IMPDH2 Induction and Nucleolar Hypertrophy., PMID:37409959
LncRNA UCA1 Participates in De Novo Synthesis of Guanine Nucleotides in Bladder Cancer by Recruiting TWIST1 to Increase IMPDH1/2., PMID:37215997
Integrated metabolomics, network pharmacology, and molecular docking to reveal the mechanisms of Isodon excisoides against drug-induced liver injury., PMID:37158044
PI3K/ c-Myc/AFF4 axis promotes pancreatic tumorigenesis through fueling nucleotide metabolism., PMID:37063434
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes., PMID:36843114
Genetic analysis of IMPDH2 gene in Taiwanese patients with isolated or combined dystonia., PMID:36657279
Rare variants in IMPDH2 cause autosomal dominant dystonia in Chinese population., PMID:36648520
c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming., PMID:36629054
IL-17A and TNF-α inhibitors induce multiple molecular changes in psoriasis., PMID:36483564
Genistein promotes apoptosis of lung cancer cells through the IMPDH2/AKT1 pathway., PMID:36398246
SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling., PMID:36177032
Genome-wide Mendelian randomization identifies actionable novel drug targets for psychiatric disorders., PMID:36114287
Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation., PMID:35833994
Quantitative Chemoproteomic Profiling of Protein Cross-Links Induced by Methylglyoxal., PMID:35797239
The pharmacogenetics of mycophenolate mofetil in Tunisian renal transplant patients., PMID:35770851
Proteomic Characterization of a Candidate Polygenic Driver of Metabolism in Non-small Cell Lung Cancer., PMID:35595168
For research use only. Not for human or drug use.
